Ángela Macia
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View article: SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir
SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir Open
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by the World Health Organization (WHO). Early clinical symptomatology foc…
View article: Transposable Elements, Inflammation, and Neurological Disease
Transposable Elements, Inflammation, and Neurological Disease Open
Transposable Elements (TE) are mobile DNA elements that can replicate and insert themselves into different locations within the host genome. Their propensity to self-propagate has a myriad of consequences and yet their biological significa…
View article: LINE-1 Evasion of Epigenetic Repression in Humans
LINE-1 Evasion of Epigenetic Repression in Humans Open
View article: Genome-wide de novo L1 Retrotransposition Connects Endonuclease Activity with Replication: insertion data and derivative models
Genome-wide de novo L1 Retrotransposition Connects Endonuclease Activity with Replication: insertion data and derivative models Open
This data repository provides access to the LINE-1 (L1) insertion site data from Flasch, et al., 2019:https://www.sciencedirect.com/science/article/pii/S0092867419302338?via%3Dihub Please see file L1_actual_and_random_insertions_help.docx …
View article: Genome-wide de novo L1 Retrotransposition Connects Endonuclease Activity with Replication
Genome-wide de novo L1 Retrotransposition Connects Endonuclease Activity with Replication Open
This data repository provides access to the LINE-1 (L1) insertion site data from Flasch, et al., 2019: https://www.sciencedirect.com/science/article/pii/S0092867419302338?via%3Dihub Please see file L1_actual_and_random_insertions_h…
View article: Genome-wide de novo L1 Retrotransposition Connects Endonuclease Activity with Replication
Genome-wide de novo L1 Retrotransposition Connects Endonuclease Activity with Replication Open
View article: LINE-1 retrotransposition impacts the genome of human pre-implantation embryos and extraembryonic tissues
LINE-1 retrotransposition impacts the genome of human pre-implantation embryos and extraembryonic tissues Open
Long Interspersed Element 1 (LINE-1/L1) is an abundant retrotransposon that has greatly impacted human genome evolution. LINE-1s are responsible for the generation of millions of insertions in the current human population. The characteriza…
View article: Author Correction: Blocking Zika virus vertical transmission
Author Correction: Blocking Zika virus vertical transmission Open
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
View article: Blocking Zika virus vertical transmission
Blocking Zika virus vertical transmission Open
The outbreak of the Zika virus (ZIKV) has been associated with increased incidence of congenital malformations. Although recent efforts have focused on vaccine development, treatments for infected individuals are needed urgently. Sofosbuvi…
View article: Modeling neuro-immune interactions during Zika virus infection
Modeling neuro-immune interactions during Zika virus infection Open
Although Zika virus (ZIKV) infection is often asymptomatic, in some cases, it can lead to birth defects in newborns or serious neurologic complications in adults. However, little is known about the interplay between immune and neural cells…
View article: Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation
Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation Open
View article: Engineered LINE-1 retrotransposition in nondividing human neurons
Engineered LINE-1 retrotransposition in nondividing human neurons Open
Half the human genome is made of transposable elements (TEs), whose ongoing activity continues to impact our genome. LINE-1 (or L1) is an autonomous non-LTR retrotransposon in the human genome, comprising 17% of its genomic mass and contai…
View article: <i>Alu</i>retrotransposons promote differentiation of human carcinoma cells through the aryl hydrocarbon receptor
<i>Alu</i>retrotransposons promote differentiation of human carcinoma cells through the aryl hydrocarbon receptor Open
Cell differentiation is a central process in development and in cancer growth and dissemination. OCT4 (POU5F1) and NANOG are essential for cell stemness and pluripotency; yet, the mechanisms that regulate their expression remain largely un…