Angela Meier
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View article: Sedation practices and associated clinical outcomes among adult ICU patients managed by advanced practice providers versus resident physicians
Sedation practices and associated clinical outcomes among adult ICU patients managed by advanced practice providers versus resident physicians Open
Patients admitted to an APP-staffed ICU were more likely to have sedation management reflective of best practice, and this practice was associated with shorter time to extubation and lower mortality.
View article: Treatment with intravenous immunoglobulin modulates coagulation- and complement-related pathways in COVID-19 patients
Treatment with intravenous immunoglobulin modulates coagulation- and complement-related pathways in COVID-19 patients Open
Introduction Intravenous immunoglobulin (IVIG) is a therapy that uses pooled immunoglobulins from thousands of different donors. While it is primarily used to treat immunodeficiency and autoimmune diseases due to its immunomodulatory prope…
View article: Integrated multiomic analysis identifies TRIP13 as a mediator of alveolar epithelial type II cell dysfunction in idiopathic pulmonary fibrosis
Integrated multiomic analysis identifies TRIP13 as a mediator of alveolar epithelial type II cell dysfunction in idiopathic pulmonary fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a lethal progressive lung disease urgently needing new therapies. Current treatments only delay disease progression, leaving lung transplant as the sole remaining option. Recent studies support a mode…
View article: Neutrophil Extracellular Traps: An Emerging Therapeutic Target to Improve Infectious Disease Outcomes
Neutrophil Extracellular Traps: An Emerging Therapeutic Target to Improve Infectious Disease Outcomes Open
Neutrophils possess a diverse repertoire of pathogen clearance mechanisms, one of which is the formation of neutrophil extracellular traps (NETs). NETs are complexes of histone proteins and DNA coated with proteolytic enzymes that are rele…
View article: Integrated multiomic analysis identifies<i>TRIP13</i>as a mediator of alveolar epithelial type II cell dysfunction in idiopathic pulmonary fibrosis
Integrated multiomic analysis identifies<i>TRIP13</i>as a mediator of alveolar epithelial type II cell dysfunction in idiopathic pulmonary fibrosis Open
SUMMARY Idiopathic pulmonary fibrosis (IPF) is a lethal progressive lung disease urgently needing new therapies. Current treatments only delay disease progression, leaving lung transplant as the sole remaining option. Recent studies suppor…
View article: Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against <i>Pseudomonas aeruginosa</i> pneumonia
Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against <i>Pseudomonas aeruginosa</i> pneumonia Open
Pseudomonas aeruginosa (PA) CbpD belongs to the lytic polysaccharide monooxygenases (LPMOs), a family of enzymes that cleave chitin or related polysaccharides. Here, we demonstrate a virulence role of CbpD in PA pneumonia linked to impairm…
View article: Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulin
Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulin Open
Pathogenesis of lung injury in COVID-19 is not completely understood, leaving gaps in understanding how current treatments modulate the course of COVID-19. Neutrophil numbers and activation state in circulation have been found to correlate…
View article: A unique case of Miller Fisher-Guillain-Barré overlap syndrome in a liver transplant recipient
A unique case of Miller Fisher-Guillain-Barré overlap syndrome in a liver transplant recipient Open
Guillain-Barré syndrome (GBS) is an ascending demyelinating polyneuropathy often associated with recent infection. Miller Fisher syndrome represents a variant with predominant facial and cranial nerve involvement, although Miller Fisher an…
View article: The Implementation and Outcomes of a Nurse-Run Extracorporeal Membrane Oxygenation Program, a Retrospective Single-Center Study
The Implementation and Outcomes of a Nurse-Run Extracorporeal Membrane Oxygenation Program, a Retrospective Single-Center Study Open
Objectives: Due to a shortage of perfusionists and increasing utilization of extracorporeal membrane oxygenation in the United States, many programs are training nurses as bedside extracorporeal membrane oxygenation specialists (i.e., nurs…
View article: Effect of Intravenous Immunoglobulin on Neutrophil Antimicrobial and Inflammatory Functions - Implications in Neutrophil-Mediated Immunopathology
Effect of Intravenous Immunoglobulin on Neutrophil Antimicrobial and Inflammatory Functions - Implications in Neutrophil-Mediated Immunopathology Open
Rationale. Neutrophils are the most abundant circulating leukocytes and the first line of defense against invading pathogens. Known for their function as phagocytic cells, neutrophils also capture and kill pathogens via elaboration of Neut…
View article: Very-Low Driving Pressure Ventilation in Patients with Acute Respiratory Distress Syndrome on Extracorporeal Membrane Oxygenation
Very-Low Driving Pressure Ventilation in Patients with Acute Respiratory Distress Syndrome on Extracorporeal Membrane Oxygenation Open
Rationale: The ideal ventilator settings in patients with severe acute respiratory distress syndrome (ARDS) while on Extracorporeal Membrane Oxygenation (ECMO) are unknown. ELSO recommends modest driving pressures and PEEP (i.e., “lung res…
View article: Increased peripheral blood neutrophil activation phenotypes and NETosis in critically ill COVID-19 patients
Increased peripheral blood neutrophil activation phenotypes and NETosis in critically ill COVID-19 patients Open
Background Increased inflammation is a hallmark of COVID-19, with pulmonary and systemic inflammation identified in multiple cohorts of patients. Definitive cellular and molecular pathways driving severe forms of this disease remain uncert…
View article: Driving Pressure for Ventilation of Patients with Acute Respiratory Distress Syndrome
Driving Pressure for Ventilation of Patients with Acute Respiratory Distress Syndrome Open
Measuring driving pressure (defined by plateau pressure minus positive end-expiratory pressure) is a useful addition to existing variables when setting mechanical ventilation, particularly in the acute respiratory distress syndrome.
View article: E-cigarette use increases susceptibility to bacterial infection by impairment of human neutrophil chemotaxis, phagocytosis, and NET formation
E-cigarette use increases susceptibility to bacterial infection by impairment of human neutrophil chemotaxis, phagocytosis, and NET formation Open
E-cigarettes are portrayed as safer relative to conventional tobacco. However, burgeoning evidence suggests that E-cigarettes may adversely affect host defenses. However, the precise mechanisms by which E-cigarette vapor alters innate immu…
View article: Inhibition of Human Neutrophil Extracellular Trap (NET) Production by Propofol and Lipid Emulsion
Inhibition of Human Neutrophil Extracellular Trap (NET) Production by Propofol and Lipid Emulsion Open
Uncontrolled bacteremia is a common and life threatening condition that can lead to sepsis and septic shock with significant morbidity and mortality. Neutrophil granulocytes, the most abundant phagocytic leukocyte of the innate immune syst…
View article: Biotechnology and Bioengineering: Volume 116, Number 4, April 2019
Biotechnology and Bioengineering: Volume 116, Number 4, April 2019 Open
US$18141 (US and Rest of World), € 11707 (Europe), £ 9260 (UK
View article: Alterations in human neutrophil function caused by bisphenol A
Alterations in human neutrophil function caused by bisphenol A Open
Bisphenol A (BPA) is a synthetic, organic compound frequently present in consumer plastics, including plastic-lined cans, water bottles, toys, and teeth sutures. Previous studies have shown that BPA can produce adverse health effects that …
View article: Leadership in Medical Emergencies Is “Highly Teachable”
Leadership in Medical Emergencies Is “Highly Teachable” Open
Sell, Rebecca E. MD; Meier, Angela MD, PhD; Sundararajan, Radhika MD, PhD; Beitler, Jeremy R. MD, MPH Author Information