Angela R. Ozburn
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View article: Chronic Ethanol Drinking Alters Medial Prefrontal Cortex and Nucleus Accumbens Astrocyte Translatome and Extracellular Matrix Glycosaminoglycans
Chronic Ethanol Drinking Alters Medial Prefrontal Cortex and Nucleus Accumbens Astrocyte Translatome and Extracellular Matrix Glycosaminoglycans Open
Alcohol Use Disorder is a leading preventable cause of morbidity and mortality, yet knowledge of mechanisms driving ethanol-related neuroplasticity remains incomplete. While research has traditionally focused on neuronal signaling, emergin…
View article: Nucleus accumbens core chemogenetic excitation in male mice and chemogenetic inhibition in female mice reduced ethanol reward
Nucleus accumbens core chemogenetic excitation in male mice and chemogenetic inhibition in female mice reduced ethanol reward Open
Background Women tend to progress from initial alcohol use to dependence more rapidly than men, a phenomenon known as the “telescoping effect”. This suggests different consequences of early alcohol use, which can impact the development of …
View article: Voluntary wheel-running reduces harmful drinking in a genetic risk model for drinking to intoxication
Voluntary wheel-running reduces harmful drinking in a genetic risk model for drinking to intoxication Open
Physical activity (PA) may provide an effective and equitable treatment option for addressing the harm associated with Alcohol Use Disorders (AUDs). Wheel-running (WR) - a well characterized rodent model of PA - reduces intake and craving …
View article: Editorial: The role, and underlying neural mechanisms of, physical activity in treating substance and alcohol use disorders
Editorial: The role, and underlying neural mechanisms of, physical activity in treating substance and alcohol use disorders Open
View article: Genomic and behavioral signatures of selection for ethanol preference from the heterogeneous stock collaborative cross mice – The central nucleus of the amygdala
Genomic and behavioral signatures of selection for ethanol preference from the heterogeneous stock collaborative cross mice – The central nucleus of the amygdala Open
Alcohol use disorder (AUD) is a complex disease with heritability of ~0.5, indicating genetic and non-genetic factors contribute to risk. Identifying gene expression networks contributing to risk using post-mortem human brain tissue has th…
View article: Apremilast reduces co-occurring alcohol drinking and mechanical allodynia and regulates central amygdala GABAergic transmission
Apremilast reduces co-occurring alcohol drinking and mechanical allodynia and regulates central amygdala GABAergic transmission Open
The FDA-approved phosphodiesterase type 4 (PDE4) inhibitor, apremilast, has been recently investigated as a pharmacotherapy for alcohol use disorder (AUD) with promising efficacy in rodent models and humans. However, apremilast's effects o…
View article: Genomic and Behavioral Signatures of Selection for Ethanol Preference from the Heterogeneous Stock Collaborative Cross Mice – The Central Nucleus of the Amygdala
Genomic and Behavioral Signatures of Selection for Ethanol Preference from the Heterogeneous Stock Collaborative Cross Mice – The Central Nucleus of the Amygdala Open
Alcohol use disorder (AUD) is a complex disease with heritability of ∼0.5, indicating genetic and non-genetic factors contribute to risk. Identifying gene expression networks contributing to risk using post-mortem human brain tissue has th…
View article: Voluntary Wheel-Running Reduces Harmful Drinking in a Genetic Risk Model for Drinking to Intoxication
Voluntary Wheel-Running Reduces Harmful Drinking in a Genetic Risk Model for Drinking to Intoxication Open
View article: Sex differences in nucleus accumbens core circuitry engaged by binge-like ethanol drinking
Sex differences in nucleus accumbens core circuitry engaged by binge-like ethanol drinking Open
Growing parity in Alcohol Use Disorder (AUD) diagnoses in men and women necessitates consideration of sex as a biological variable. In humans and rodents, the nucleus accumbens core (NAcc) regulates alcohol binge drinking, a risk factor fo…
View article: Codeveloping and implementing an Indigenous mentoring program for Native American faculty in science, technology, engineering, and mathematics.
Codeveloping and implementing an Indigenous mentoring program for Native American faculty in science, technology, engineering, and mathematics. Open
View article: Development and implementation of a Dependable, Simple, and Cost-effective (DSC), open-source running wheel in High Drinking in the Dark and Heterogeneous Stock/Northport mice
Development and implementation of a Dependable, Simple, and Cost-effective (DSC), open-source running wheel in High Drinking in the Dark and Heterogeneous Stock/Northport mice Open
Maintaining healthy and consistent levels of physical activity (PA) is a clinically proven and low-cost means of reducing the onset of several chronic diseases and may provide an excellent strategy for managing mental health and related ou…
View article: Repurposing anti-inflammatory medications for alcohol and substance use disorders
Repurposing anti-inflammatory medications for alcohol and substance use disorders Open
View article: Preclinical and clinical evidence for suppression of alcohol intake by apremilast
Preclinical and clinical evidence for suppression of alcohol intake by apremilast Open
Treatment options for alcohol use disorders (AUDs) have minimally advanced since 2004, while the annual deaths and economic toll have increased alarmingly. Phosphodiesterase type 4 (PDE4) is associated with alcohol and nicotine dependence.…
View article: Modeling Brain Gene Expression in Alcohol Use Disorder with Genetic Animal Models
Modeling Brain Gene Expression in Alcohol Use Disorder with Genetic Animal Models Open
View article: Brain gene expression differences related to ethanol preference in the collaborative cross founder strains
Brain gene expression differences related to ethanol preference in the collaborative cross founder strains Open
The collaborative cross (CC) founder strains include five classical inbred laboratory strains [129S1/SvlmJ (S129), A/J (AJ), C57BL/6J (B6), NOD/ShiLtJ (NOD), and NZO/HILtJ (NZO)] and three wild-derived strains [CAST/EiJ (CAST), PWK/PhJ (PW…
View article: Targeting the Maladaptive Effects of Binge Drinking on Circadian Gene Expression
Targeting the Maladaptive Effects of Binge Drinking on Circadian Gene Expression Open
Previous studies (1) support a role of circadian genes in regulating alcohol intake, and (2) reveal that harmful alcohol use alters circadian rhythms. However, there is minimal knowledge of the effects of chronic alcohol processes on rhyth…
View article: Midazolam, methamphetamine, morphine and nicotine intake in high‐drinking‐in‐the‐dark mice
Midazolam, methamphetamine, morphine and nicotine intake in high‐drinking‐in‐the‐dark mice Open
The high‐drinking‐in‐the‐dark (HDID) lines of mice were selectively bred for achieving high blood alcohol levels in the drinking‐in‐the‐dark (DID) task and have served as a unique genetic risk model for binge‐like alcohol intake. However, …
View article: Corticosterone Levels and Glucocorticoid Receptor Gene Expression in High Drinking in the Dark Mice and Their Heterogeneous Stock (HS/NPT) Founder Line
Corticosterone Levels and Glucocorticoid Receptor Gene Expression in High Drinking in the Dark Mice and Their Heterogeneous Stock (HS/NPT) Founder Line Open
The High Drinking in the Dark (HDID-1) line of mice has been selectively bred for achieving high blood alcohol levels (BALs) in the Drinking in the Dark task, a model of binge-like drinking. Recently, we determined that glucocorticoid rece…
View article: Regulation of alcohol drinking by ventral striatum and extended amygdala circuitry
Regulation of alcohol drinking by ventral striatum and extended amygdala circuitry Open
View article: Exploring personal, relational, and collective experiences and mentorship connections that enhance or inhibit professional development and career advancement of native American faculty in STEM fields: A qualitative study.
Exploring personal, relational, and collective experiences and mentorship connections that enhance or inhibit professional development and career advancement of native American faculty in STEM fields: A qualitative study. Open
View article: Central nucleus of the amygdala projections onto the nucleus accumbens core regulate binge-like alcohol drinking in a CRF-dependent manner
Central nucleus of the amygdala projections onto the nucleus accumbens core regulate binge-like alcohol drinking in a CRF-dependent manner Open
View article: On the Use of Heterogeneous Stock Mice to Map Transcriptomes Associated With Excessive Ethanol Consumption
On the Use of Heterogeneous Stock Mice to Map Transcriptomes Associated With Excessive Ethanol Consumption Open
We and many others have noted the advantages of using heterogeneous (HS) animals to map genes and gene networks associated with both behavioral and non-behavioral phenotypes. Importantly, genetically complex Mus musculus crosses provide su…
View article: Long‐term alcohol drinking in High Drinking in the Dark mice is stable for many months and does not show alcohol deprivation effects
Long‐term alcohol drinking in High Drinking in the Dark mice is stable for many months and does not show alcohol deprivation effects Open
We have modelled genetic risk for binge‐like drinking by selectively breeding High Drinking in the Dark‐1 and ‐2 (HDID‐1 and HDID‐2) mice for their propensity to reach intoxicating blood alcohol levels (BALs) after binge‐like drinking in a…
View article: The FDA-approved drug apremilast suppresses alcohol intake: clinical and pre-clinical validation
The FDA-approved drug apremilast suppresses alcohol intake: clinical and pre-clinical validation Open
Treatment options for Alcohol Use Disorders (AUD) have minimally advanced since 2004, while the annual deaths and economic toll have become alarmingly high. Bringing potential therapeutics beyond the bench and into the clinic for AUD requi…
View article: Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder
Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder Open
View article: The impact of Drinking in the Dark (DID) procedural manipulations on ethanol intake in High Drinking in the Dark (HDID) mice
The impact of Drinking in the Dark (DID) procedural manipulations on ethanol intake in High Drinking in the Dark (HDID) mice Open
View article: Ethanol-Related Behaviors in Mouse Lines Selectively Bred for Drinking to Intoxication
Ethanol-Related Behaviors in Mouse Lines Selectively Bred for Drinking to Intoxication Open
Alcohol use disorder (AUD) is a devastating psychiatric disorder that has significant wide-reaching effects on individuals and society. Selectively bred mouse lines are an effective means of exploring the genetic and neuronal mechanisms un…
View article: Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2
Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2 Open
View article: Effects of chemogenetic manipulation of the nucleus accumbens core in male C57BL/6J mice
Effects of chemogenetic manipulation of the nucleus accumbens core in male C57BL/6J mice Open
View article: Tetracycline derivatives reduce binge alcohol consumption in High Drinking in the Dark mice
Tetracycline derivatives reduce binge alcohol consumption in High Drinking in the Dark mice Open