Angela Schell
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View article: Treating Menière’s disease with rimegepant
Treating Menière’s disease with rimegepant Open
A recent hypothesis states that Menière’s disease is caused by inappropriate expression, i.e. enhanced release of the neurotransmitter calcitonin gene-related peptide. Here, we tested this hypothesis by administering rimegepant, a new calc…
View article: Assessing long-term, vestibulotoxic side effects after gentamicin therapy in neonatal sepsis or infection using video head impulse test
Assessing long-term, vestibulotoxic side effects after gentamicin therapy in neonatal sepsis or infection using video head impulse test Open
Study background Newborn infection and sepsis remain serious problems. Guideline-compliant therapy includes, among other therapeutics, calculated intravenous antibiosis with gentamicin. One of the known side effects of gentamicin is severe…
View article: The effects of COVID-19 on the vestibular system
The effects of COVID-19 on the vestibular system Open
Introduction The symptoms and severity of SARS-CoV-2 infection vary greatly across the spectrum, from asymptomatic infection to severe pneumonia with acute respiratory distress syndrome and even death. Dizziness is a frequently reported sy…
View article: Anosmia Testing as Early Detection of SARS-CoV-2 Positivity; A Prospective Study under Screening Conditions
Anosmia Testing as Early Detection of SARS-CoV-2 Positivity; A Prospective Study under Screening Conditions Open
Sudden onset of anosmia is a phenomenon often associated with developing COVID-19 disease and has even been described as an initial isolated symptom in individual cases. In this case-control study, we investigated the feasibility of this c…
View article: Development of AI based soft tissue shift tracking during surgery to optimize frozen section analysis
Development of AI based soft tissue shift tracking during surgery to optimize frozen section analysis Open
Introduction Management of frozen section analysis (FC) during tumor resection should be optimized using artificial intelligence (AI). FC results should be transferred precisely into the resection cavity with a common target coordinate sys…
View article: Assessment of listening effort during OlSa sentence perception tests.
Assessment of listening effort during OlSa sentence perception tests. Open
Listening effort (LE) is a potential measure for successful hearing in daily life, and it may limit hearing rehabilitation in Cochlear Implant (CI) users. To test the validity of LE measures, we evaluated LE in listeners with normal hearin…
View article: SARS-CoV2 and the vestibular System
SARS-CoV2 and the vestibular System Open
Symptoms and severity of SARS-CoV-2 infection vary greatly. Dizziness is a frequently reported symptom of SARS-CoV-2 viral infection. However, the extent to which this symptom is a result of the effect of SARS-CoV-2 on the vestibular syste…
View article: Post-COVID-19 Impairment of the Senses of Smell, Taste, Hearing, and Balance
Post-COVID-19 Impairment of the Senses of Smell, Taste, Hearing, and Balance Open
Background: Various symptoms have been associated with COVID-19, but little is known about the impacts of COVID-19 on the sensory system, risk factors, and the duration of symptoms. This study assesses olfactory, gustatory, hearing, and ve…
View article: Methods for measuring pre-, intra-, and postoperative skin thickness for cochlear implants
Methods for measuring pre-, intra-, and postoperative skin thickness for cochlear implants Open
All three measurements methods provided a suitable base for determining the ideal magnetic force. However, of particular interest were the pre- and postoperative CT measurements. The first enabled the early assessment of the required magne…
View article: Prevalence of subjective impairments of the sense of smell and taste in employees of retirement and nursing homes during SARS‐CoV‐2 pandemic
Prevalence of subjective impairments of the sense of smell and taste in employees of retirement and nursing homes during SARS‐CoV‐2 pandemic Open
Aim To investigate the usability of querying subjective impairments of the sense of smell and taste in order to improve pre‐test probability in testing for SARS‐CoV‐2. To achieve this, exploring the prevalence of these restrictions in the …
View article: Case Report: Bilateral Palsy of the Vocal Cords After COVID-19 Infection
Case Report: Bilateral Palsy of the Vocal Cords After COVID-19 Infection Open
During the COVID-19 pandemic, adverse neurological effects have been described. In addition to unspecific neurological symptoms, cranial nerve deficits have appeared as part of SARS-CoV-2 infection. In this case report, we describe a 74-ye…
View article: SHIMPs in pediatric vestibular diagnostics
SHIMPs in pediatric vestibular diagnostics Open
Introduction The incidence of vestibular dysbalance and vertigo during childhood is increasing and thus the need for appropriate testing procedures to detect peripheral vestibular hypofunction. In order to ensure a reliable diagnosis and m…
View article: Evaluation of the Oldenburg sentence test using speech recognition software
Evaluation of the Oldenburg sentence test using speech recognition software Open
Introduction Language tests have a high clinical relevance for medical care. To realistically capture the speech understanding of hearing-impaired people, sentence tests are used, which are sometimes time-consuming. Automating the test usi…
View article: Characteristics of hyp- and anosmia in the context of Covid-19 infections
Characteristics of hyp- and anosmia in the context of Covid-19 infections Open
Introduction In the context of Covid-19, hyp- and anosmia are observed, which are different to the already known post-viral olfactory dysfunction. With limited diagnostic test resources, the early detection of symptoms and their specificit…
View article: Augmented Reality during Parotid Surgery: Real-Life Evaluation of Voice Control and User-Experience
Augmented Reality during Parotid Surgery: Real-Life Evaluation of Voice Control and User-Experience Open
Content Introduction Augmented Reality (AR) can improve surgical planing and performance in parotid surgery. For easier application during surgery we implemented a complete voice control manual for our AR system used for parotid surgery. T…
View article: Maximum isometric tongue force in patients with obstructive sleep apnoea
Maximum isometric tongue force in patients with obstructive sleep apnoea Open
Background Obstructive sleep apnea (OSA) is a sleep disorder with a prevalence of 9–38%. The underlying pathology in OSA is a collapse of the upper airway. Especially in more severely affected patients, this collapse is often located at th…
View article: Apoptosis-related Proteins Are Altered by Selective Tyrosine Kinase Inhibitors and Everolimus in HPV-dependent SCC
Apoptosis-related Proteins Are Altered by Selective Tyrosine Kinase Inhibitors and Everolimus in HPV-dependent SCC Open
This is the first study to analyze the influence of TKIs and everolimus on key proteins of apoptosis. Our results provide novel information contributing to a better understanding of the cell biology of HPV-dependent HNSCC and might contrib…
View article: Leiomyosarcoma of the Nasal Cavity
Leiomyosarcoma of the Nasal Cavity Open
Leiomyosarcoma (LMS) in the sinonasal tract (SNT) is a rarity that has been firstly described in 1958. Since then, there have been only a few articles about this entity. Most of the data available about LMS in the SNT is derived from case …
View article: Changes in Vestibular Function in Patients With Head-and-Neck Cancer Undergoing Chemoradiation
Changes in Vestibular Function in Patients With Head-and-Neck Cancer Undergoing Chemoradiation Open
Introduction: While the cochleotoxicity of cisplatin has been well investigated, less is known about the effects of platinum-based chemotherapy on the vestibular system. In particular, there is a lack of prospective studies using modern la…
View article: Tyrosine Kinase Inhibitors and Everolimus Reduce IGF1R Expression in HPV16-positive and -negative Squamous Cell Carcinoma
Tyrosine Kinase Inhibitors and Everolimus Reduce IGF1R Expression in HPV16-positive and -negative Squamous Cell Carcinoma Open
The crosstalk between epidermal growth factor receptors and IGF1R could be of central interest for the development of novel medical approaches for individualized therapy.
View article: Initial manifestation of a diffus large B-Cell-Lymphoma of the paranasal sinuses
Initial manifestation of a diffus large B-Cell-Lymphoma of the paranasal sinuses Open
Case Report A 76-year-old female patient experiences a fall after months of diplopia and gelatinous rhinorrhoea The patient negated epistaxis, hyposmia and B symptoms.
View article: What happens to spontaneous nystagmus during sleep in patients with acute unilateral vestibulopathy?
What happens to spontaneous nystagmus during sleep in patients with acute unilateral vestibulopathy? Open
Introduction It is known that spontaneous nystagmus (SPN) in patients with acute unilateral vestibulopathy (AUV) can be suppressed by narcosis or medication. It is less well known if or how an SPN changes during sleep. The aim of this stud…
View article: Nightly Hypoxia Does Not Seem to Lead to Otolith Dysfunction in Patients With Obstructive Sleep Apnea
Nightly Hypoxia Does Not Seem to Lead to Otolith Dysfunction in Patients With Obstructive Sleep Apnea Open
Objectives: Obstructive sleep apnea (OSA) is a common sleep disorder, which is associated with recurrent oxygen desaturation during sleep. It has already been shown that nocturnal hypoxia may lead to cochlear dysfunction in patients with O…
View article: Cocaine Reduces Ciliary Beat Frequency of Human Nasal Epithelial Cells
Cocaine Reduces Ciliary Beat Frequency of Human Nasal Epithelial Cells Open
We assume that CBF reduction is part of the pathomechanism leading to nasal complications in cocaine abuse. Considering these results, clinical usage of cocaine should be critically evaluated and restricted to select cases only.