Angela Tewari
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View article: CD24 Irritant contact dermatitis from <i>Dieffenbachia schott</i>: a case report of a florid reaction to a common household plant
CD24 Irritant contact dermatitis from <i>Dieffenbachia schott</i>: a case report of a florid reaction to a common household plant Open
Dieffenbachia Schott, commonly known as dumb cane, is a popular ornamental house plant renowned for its striking foliage. The plant’s sap contains calcium oxalate crystals, which can cause irritant or allergic contact dermatitis upon direc…
View article: PA40 B-cell lymphoblastic lymphoma in a paediatric patient
PA40 B-cell lymphoblastic lymphoma in a paediatric patient Open
A 5-month-old girl presented with two progressively enlarging scalp lumps over 2 months. Initially treated for a scaly patch with topical antifungals, she was later referred to dermatology, where a firm 2 × 2-cm subcutaneous nodule was not…
View article: PA20 Case series: effectiveness and safety of dupilumab for liver transplant recipients in paediatric patients with eczema
PA20 Case series: effectiveness and safety of dupilumab for liver transplant recipients in paediatric patients with eczema Open
An eruptive eczematous eruption after oral tacrolimus use has been described. Histology shows eczema (with lymphocyte and eosinophils), which is thought to be secondary to an immune switch due to selective T helper 1 blockage. This type of…
View article: PA46 Clinical features, triggers and management of paediatric Stevens–Johnson syndrome: a case series from 2019 to 2024
PA46 Clinical features, triggers and management of paediatric Stevens–Johnson syndrome: a case series from 2019 to 2024 Open
Stevens–Johnson syndrome (SJS) is a severe mucocutaneous condition characterized by epidermal necrosis and mucosal involvement and is typically triggered by medications, although infections have also been implicated. Despite its rarity, an…
View article: Human skin CD141+ dendritic cells regulate cutaneous immunity via the neuropeptide urocortin 2
Human skin CD141+ dendritic cells regulate cutaneous immunity via the neuropeptide urocortin 2 Open
Skin immune homeostasis is a multi-faceted process where dermal dendritic cells (DDCs) are key in orchestrating responses to environmental stressors. We have previously identified CD141+CD14+ DDCs as a skin-resident immunoregulatory popula…
View article: A study into how ultraviolet radiation from the sun effects genes in the skin
A study into how ultraviolet radiation from the sun effects genes in the skin Open
The sun emits two main types of ultraviolet radiation (UVR): UVB (~5%) and UVA (~95%). We know that UVR from the sun causes sunburn (inflammation) as well as many other adverse (negative) effects including weakening the skin's immunity, ac…
View article: Dose and time effects of solar‐simulated ultraviolet radiation on the <i>in vivo</i> human skin transcriptome
Dose and time effects of solar‐simulated ultraviolet radiation on the <i>in vivo</i> human skin transcriptome Open
The UV radiation doses of this acute study are readily achieved daily during holidays in the sun, suggesting that the skin transcriptional profile of 'typical' holiday makers is markedly deregulated. What's already known about this topic? …
View article: Optimal sunscreen use prevents holiday erythema
Optimal sunscreen use prevents holiday erythema Open
Rates of skin cancer are increasing more rapidly in the UK than any other form of cancer. The deadliest form of the disease is melanoma skin cancer, which affects 128% more people now than it did 28 years ago. Sun protection factors (SPFs)…
View article: Sunscreen applied at ≥ 2 mg cm<sup>−2</sup>during a sunny holiday prevents erythema, a biomarker of ultraviolet radiation‐induced<scp>DNA</scp>damage and suppression of acquired immunity
Sunscreen applied at ≥ 2 mg cm<sup>−2</sup>during a sunny holiday prevents erythema, a biomarker of ultraviolet radiation‐induced<span>DNA</span>damage and suppression of acquired immunity Open
Optimal sunscreen use prevents erythema during a sunny holiday. Erythema predicts suppression of CHS (implying a shared action spectrum). Given that erythema and CPDs share action spectra, the data strongly suggest that optimal sunscreen u…