Angela Zanfardino
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View article: Adrenal response at the onset of type 1 diabetes mellitus in children and its association with acute metabolic and kidney complications
Adrenal response at the onset of type 1 diabetes mellitus in children and its association with acute metabolic and kidney complications Open
View article: Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth
Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth Open
Context Anti-transglutaminase antibodies (anti-TTG IgA) titer is associated with mucosal damage in celiac disease (CD). Objective The primary focus was to correlate anti-TTG IgA titer, HbA1c when CD occurs (HbA1cCD), and Marsh grade in chi…
View article: Risk Factors for Reintervention in Children with Subvalvular Aortic Stenosis: A 20-Year Single-Center Study
Risk Factors for Reintervention in Children with Subvalvular Aortic Stenosis: A 20-Year Single-Center Study Open
Subvalvular aortic stenosis (SAS) is a frequent cause of left ventricular outflow tract (LVOT) obstruction in children. Surgical resection is the standard treatment, yet recurrence requiring reintervention remains a significant concern. We…
View article: Altered branched chain ketoacids underlie shared metabolic phenotypes in type 1 diabetes and maple syrup urine disease
Altered branched chain ketoacids underlie shared metabolic phenotypes in type 1 diabetes and maple syrup urine disease Open
These results indicate that T1D hematological alterations at onset might act as biomarkers linked to circulating levels of short-chain acyl-carnitines, providing risk stratification for T1D and potentially for MSUD. Carnitine metabolism ma…
View article: Polygenic score from MODY genes is associated with type 1 diabetes and disease characteristics
Polygenic score from MODY genes is associated with type 1 diabetes and disease characteristics Open
View article: Neonatal diabetes–associated missense PDX1 variant disrupts chromatin association and protein-protein interaction
Neonatal diabetes–associated missense PDX1 variant disrupts chromatin association and protein-protein interaction Open
PDX1 mutations are associated with multiple forms of diabetes, including syndromic, neonatal, mature onset diabetes of the young (MODY), and type 2 diabetes. Two PDX1 missense mutations (Thr151Met and Asn196Thr) were identified in a pediat…
View article: Corrigendum to “Characterisation of transfusion-dependent prediabetes using continuous glucose monitoring: The Haemoglycare study” [Diab. Res. Clin. Pract. 222 (2025) 112076]
Corrigendum to “Characterisation of transfusion-dependent prediabetes using continuous glucose monitoring: The Haemoglycare study” [Diab. Res. Clin. Pract. 222 (2025) 112076] Open
View article: Characterisation of transfusion-dependent prediabetes using continuous glucose monitoring: The Haemoglycare study
Characterisation of transfusion-dependent prediabetes using continuous glucose monitoring: The Haemoglycare study Open
CGM reliably detects prediabetes in 37 % of TDT patients. TAR140 > 6 % may serve as a diagnostic cutoff.
View article: Sensitivity to thyroid hormones in children developing acute kidney injury at the onset of type 1 diabetes mellitus
Sensitivity to thyroid hormones in children developing acute kidney injury at the onset of type 1 diabetes mellitus Open
View article: Acidosis at Diagnosis of Type 1 Diabetes Mellitus: Relation With Kidney Function
Acidosis at Diagnosis of Type 1 Diabetes Mellitus: Relation With Kidney Function Open
Aims Acidosis at type 1 diabetes mellitus (T1DM) onset results from unregulated massive overproduction of ketoacids. However, renal tubular damage (RTD), a complication of T1DM onset, may impair bicarbonate reabsorption, exacerbating acido…
View article: Seasonality in Type 1 Diabetes Mellitus and Other Autoimmune Diseases Based on Severity of Immunity: Elucidating the Etiology with 40 years of Analysis
Seasonality in Type 1 Diabetes Mellitus and Other Autoimmune Diseases Based on Severity of Immunity: Elucidating the Etiology with 40 years of Analysis Open
Purpose: Some studies discuss the seasonality of T1DM, none of them evaluate this relationship based on the severity of immune response.We aimed to elucidate the role of the severity of autoimmunity and environmental factors in the etiolog…
View article: Development and validation of a novel method for evaluation of multiple islet autoantibodies in dried blood spot using dissociation‐enhanced lanthanide fluorescent immunoassays technology, specific and suitable for paediatric screening programmes
Development and validation of a novel method for evaluation of multiple islet autoantibodies in dried blood spot using dissociation‐enhanced lanthanide fluorescent immunoassays technology, specific and suitable for paediatric screening programmes Open
View article: Fear of hypoglycemia in parents of children with type 1 diabetes trained for intranasal glucagon use
Fear of hypoglycemia in parents of children with type 1 diabetes trained for intranasal glucagon use Open
Training and educating parents on IN glucagon use can help them effectively manage hypoglycemic episodes and alleviate the fear that generally accompany such events.
View article: Recommendations for recognizing, risk stratifying, treating, and managing children and adolescents with hypoglycemia
Recommendations for recognizing, risk stratifying, treating, and managing children and adolescents with hypoglycemia Open
There has been continuous progress in diabetes management over the last few decades, not least due to the widespread dissemination of continuous glucose monitoring (CGM) and automated insulin delivery systems. These technological advances …
View article: Sustained effectiveness of an advanced hybrid closed loop system in a cohort of children and adolescents with type 1 diabetes: a one-year real-world study
Sustained effectiveness of an advanced hybrid closed loop system in a cohort of children and adolescents with type 1 diabetes: a one-year real-world study Open
Objective. To investigate glucose metrics and identify potential predictors of the achievement of glycemic outcomes in children and adolescents during their first 12 months of MiniMed™ 780G use. Research design and methods. In this multice…
View article: Sustained Effectiveness of an Advanced Hybrid Closed-Loop System in a Cohort of Children and Adolescents With Type 1 Diabetes: A 1-Year Real-World Study
Sustained Effectiveness of an Advanced Hybrid Closed-Loop System in a Cohort of Children and Adolescents With Type 1 Diabetes: A 1-Year Real-World Study Open
OBJECTIVE To investigate glucose metrics and identify potential predictors of the achievement of glycemic outcomes in children and adolescents during their first 12 months of MiniMed 780G use. RESEARCH DESIGN AND METHODS This multicenter, …
View article: Sustained effectiveness of an advanced hybrid closed loop system in a cohort of children and adolescents with type 1 diabetes: a one-year real-world study
Sustained effectiveness of an advanced hybrid closed loop system in a cohort of children and adolescents with type 1 diabetes: a one-year real-world study Open
Objective. To investigate glucose metrics and identify potential predictors of the achievement of glycemic outcomes in children and adolescents during their first 12 months of MiniMed™ 780G use. Research design and methods. In this multice…
View article: Maintaining a gluten-free diet is associated with quality of life in youths with type 1 diabetes and celiac disease
Maintaining a gluten-free diet is associated with quality of life in youths with type 1 diabetes and celiac disease Open
View article: The real-life management of glucose homeostasis abnormalities in pediatric onco-hematological diseases: data from a national survey
The real-life management of glucose homeostasis abnormalities in pediatric onco-hematological diseases: data from a national survey Open
Glycemic abnormalities are a frequent finding in pediatric oncological patients, both during treatment and after its discontinuation. Moreover, impaired glucose tolerance (IGT), impaired fasting glycemia (IFG) and diabetes mellitus (DM) ar…
View article: The real-life management of glucose homeostasis abnormalities in pediatric onco-hematological diseases: data from a national survey
The real-life management of glucose homeostasis abnormalities in pediatric onco-hematological diseases: data from a national survey Open
Glycemic abnormalities are a frequent finding in pediatric oncological patients, both during treatment and after its discontinuation. Moreover, impaired glucose tolerance (IGT), impaired fasting glycemia (IFG) and diabetes mellitus (DM) ar…
View article: C-peptide: Stepping Out of Insulin’s Shadow and into the Spotlight
C-peptide: Stepping Out of Insulin’s Shadow and into the Spotlight Open
View article: Psychological consequences of the COVID-19 pandemic in people with type 1 diabetes: A systematic literature review
Psychological consequences of the COVID-19 pandemic in people with type 1 diabetes: A systematic literature review Open
View article: The Pathogenic Diagnosis in Pediatric Diabetology: Next Generation Sequencing and Precision Therapy
The Pathogenic Diagnosis in Pediatric Diabetology: Next Generation Sequencing and Precision Therapy Open
In pediatric diabetology, a precise diagnosis is very important because it allows early and correct clinical management of the patient. Monogenic diabetes (MD), which accounts for 1–6% of all pediatric–adolescent diabetes cases, is the mos…
View article: Euthyroid sick syndrome and its association with complications of type 1 diabetes mellitus onset
Euthyroid sick syndrome and its association with complications of type 1 diabetes mellitus onset Open
View article: Lifestyle and physical fitness in adolescents with type 1 diabetes and obesity
Lifestyle and physical fitness in adolescents with type 1 diabetes and obesity Open
T1DM adolescents did not meet the recommendations for active lifestyle, despite a medium/good adherence to MD, in particular in NW and OW youths. Sedentary habits correlated with a poor HbA1c. Further, reduced agility and balance were obse…
View article: Supplementary Material for: Glycemic variability and Time in range are associated with the risk of overweight and high LDL-cholesterol in children and youths with Type 1 Diabetes.
Supplementary Material for: Glycemic variability and Time in range are associated with the risk of overweight and high LDL-cholesterol in children and youths with Type 1 Diabetes. Open
Introduction: Reducing cardiovascular risk factors (CVRFs) exposure in children and youths with type 1 diabetes (T1D) is critical for cardiovascular diseases (CVD) prevention. Long-term exposure to hyperglycaemia, measured by HbA1c, had be…
View article: COVID-19 forced restrictions did not affect metabolic control in youth with T2D in Italy
COVID-19 forced restrictions did not affect metabolic control in youth with T2D in Italy Open
View article: Time With Glucose Level in Target Range Among Children and Adolescents With Type 1 Diabetes After a Software Update to a Closed-Loop Glucose Control System
Time With Glucose Level in Target Range Among Children and Adolescents With Type 1 Diabetes After a Software Update to a Closed-Loop Glucose Control System Open
: This cohort study analyzes changes to the time with glucose level in target range among children and adolescents with type 1 diabetes after a software update to a closed-loop glucose control system.
View article: Corrigendum: The silent epidemic of diabetic ketoacidosis at diagnosis of type 1 diabetes in children and adolescents in italy during the covid-19 pandemic in 2020
Corrigendum: The silent epidemic of diabetic ketoacidosis at diagnosis of type 1 diabetes in children and adolescents in italy during the covid-19 pandemic in 2020 Open
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View article: Uric acid and cardiometabolic risk by gender in youth with type 1 diabetes
Uric acid and cardiometabolic risk by gender in youth with type 1 diabetes Open