Explanipedia

Biomaterials and cell-based therapy post spinal cord injury Open

Sara Haratizadeh, Haitao Liu, Hengde Li, Mohsen Adeli, Angelo H. All · 2025

Spinal cord injury (SCI) imposes a significant physical, social, and economic burden on millions of patients and their families worldwide. Although medical and surgical care improvements have decreased mortality rates, sustained recovery r…

Computation of statistical power and sample size for in vivo research models Open

Hasan Al‐Nashash, Jiajin Wei, Ke Yang, Ayman Alzaatreh, Mohsen Mahdavi Adeli , et al. · 2025

Sample size calculation is crucial in biomedical in vivo research investigations mainly for two reasons: to design the most resource-efficient studies and to safeguard ethical issues when alive animals are subjects of testing. In this cont…

Two‐Dimensional Polycyclodextrins for Strong Multivalent Host‐Guest Interactions at Biointerfaces Open

Zahra Moazzami Goudarzi, Zahra Mohammadi, Reza Maleki, Siamak Beyranvand, Chuanxiong Nie , et al. · 2025

While 2D polymers with aromatic backbones have been increasingly receiving interest from various scientific disciplines, their nonaromatic counterparts are less investigated. In this work, 2D poly( β ‐cyclodextrin)s (2D‐CDs) with few hundr…

Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked Potential Open

Angelo H. All, Ka‐Leung Wong, Hasan Al‐Nashash · 2024

This study involves longitudinal neuro-electrophysiological analysis using motor-evoked potentials (MEP) and the Basso, Beattie, and Bresnahan behavioral examinations (BBB) to evaluate moderate mid-thoracic contusive spinal cord injury (SC…

Hypothermia effects on neuronal plasticity post spinal cord injury Open

Hasan Al‐Nashash, Ka‐Leung Wong, Angelo H. All · 2024

Background SCI is a time-sensitive debilitating neurological condition without treatment options. Although the central nervous system is not programmed for effective endogenous repairs or regeneration, neuroplasticity partially compensates…

Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier Open

Shuai Zha, Haitao Liu, Hengde Li, Haolan Li, Ka‐Leung Wong , et al. · 2024

The blood-brain barrier (BBB) is a specialized semipermeable structure that highly regulates exchanges between the central nervous system parenchyma and blood vessels. Thus, the BBB also prevents the passage of various forms of therapeutic…

Lanthanide-doped upconversion nanoparticles as nanoprobes for bioimaging Open

Hengde Li, Haitao Liu, Ka‐Leung Wong, Angelo H. All · 2024

Upconversion nanoparticles (UCNPs) have great potential in biomedical applications such as biomolecular detection, cell imaging, tumor diagnosis and deep tissue imaging.

Sensitive and responsive upconversion nanoprobes for fluorescence turn-on detection of glucose concentration Open

Shuai Zha, Haolan Li, Ga‐Lai Law, Ka‐Leung Wong, Angelo H. All · 2023

Intranasal Delivery of Functionalized Polymeric Nanomaterials to the Brain (Adv. Healthcare Mater. 11/2022) Open

Shuai Zha, Ka‐Leung Wong, Angelo H. All · 2022

Intranasal Delivery In article number 2102610, Angelo H. All and co-workers review the intranasal (IN) delivery of polymeric nanomaterials containing therapeutic agents to the brain and their current challenges and future perspectives. Fun…

Monitoring Setup, Signal Processing, and Statistical Analysis for Somatosensory and Motor Evoked Potentials to Assess Nervous System Open

Angelo H. All, Hasan Al‐Nashash, Ayman Alzaatreh · 2022

Characterization of transection spinal cord injuries by monitoring somatosensory evoked potentials and motor behavior Open

Angelo H. All, Hasan Al‐Nashash, Hasan Mir, Shiyu Luo, Xiaogang Liu · 2019

In Vivo Tumor Visualization through MRI Off‐On Switching of NaGdF<sub>4</sub>–CaCO<sub>3</sub> Nanoconjugates Open

Zhigao Yi, Zichao Luo, Nicole D. Barth, Xianfu Meng, Hong Liu , et al. · 2019

The development of high‐performance contrast agents in magnetic resonance imaging (MRI) has recently received considerable attention, as they hold great promise and potential as a powerful tool for cancer diagnosis. Despite substantial ach…

Upconversion amplification through dielectric superlensing modulation Open

Liangliang Liang, Daniel Boon Loong Teh, Ngoc‐Duy Dinh, Weiqiang Chen, Qiushui Chen , et al. · 2019

Transcriptome Analysis Reveals Neuroprotective aspects of Human Reactive Astrocytes induced by Interleukin 1β Open

Daniel Boon Loong Teh, Ankshita Prasad, Wenxuan Jiang, Mohd. Zacky Ariffin, Sanjay Khanna , et al. · 2017

Reactive astrogliosis is a critical process in neuropathological conditions and neurotrauma. Although it has been suggested that it confers neuroprotective effects, the exact genomic mechanism has not been explored. The prevailing dogma of…

Binary temporal upconversion codes of Mn2+-activated nanoparticles for multilevel anti-counterfeiting Open

Xiaowang Liu, Yu Wang, Xiyan Li, Zhigao Yi, Renren Deng , et al. · 2017

Static Magnetic Field Stimulation Enhances Oligodendrocyte Differentiation and Secretion of Neurotrophic Factors Open

Ankshita Prasad, Daniel Boon Loong Teh, Agata Blasiak, Chou Chai, Yang Wu , et al. · 2017

Subcellular electrical stimulation of neurons enhances the myelination of axons by oligodendrocytes Open

Hae Ung Lee, Agata Blasiak, Devansh R. Agrawal, Daniel Boon Loong Teh, Nitish V. Thakor , et al. · 2017

Myelin formation has been identified as a modulator of neural plasticity. New tools are required to investigate the mechanisms by which environmental inputs and neural activity regulate myelination patterns. In this study, we demonstrate a…

A Review of Induced Pluripotent Stem Cell, Direct Conversion by Trans-Differentiation, Direct Reprogramming and Oligodendrocyte Differentiation Open

Ankshita Prasad, Janani Manivannan, Daniel Boon Loong Teh, Soo Min Chua, Payam Gharibani , et al. · 2016

Rapid progress in the field of stem cell therapy and cellular reprogramming provides convincing evidence of its feasibility in treating a wide range of pathologies through autologous cell replacement therapy. This review article describes …

Bright field microscopy images of the various stages of oligodendrocyte differentiation from induced pluripotent stem cells of the BC1 line. Open

Angelo H. All, Payam Gharibani, Siddharth Gupta, Faith A. Bazley, Nikta Pashai , et al. · 2015

(A) The undifferentiated cells grew in colonies on a mouse embryonic fibroblast feeder layer, (B) Embroid bodies (EBs) were formed by suspending the undifferentiating cells in culture on ultra-low adherence plates, (C) 15-day EBs were plat…

Direct Reprogramming of Human Primordial Germ Cells into Induced Pluripotent Stem Cells: Efficient Generation of Genetically Engineered Germ Cells Open

Faith A. Bazley, Cyndi F. Liu, Xuan Yuan, Haiping Hao, Angelo H. All , et al. · 2015

Primordial germ cells (PGCs) share many properties with embryonic stem cells (ESCs) and innately express several key pluripotency-controlling factors, including OCT4, NANOG, and LIN28. Therefore, PGCs may provide a simple and efficient mod…

Prolonged Local Hypothermia Has No Long-Term Adverse Effect on the Spinal Cord Open

Ashwati Vipin, Jukka Kortelainen, Hasan Al‐Nashash, Soo Min Chua, Xinyuan Thow , et al. · 2015

Hypothermia is known to be neuroprotective and is one of the most effective and promising first-line treatments for central nervous system (CNS) trauma. At present, induction of local hypothermia, as opposed to general hypothermia, is more…

Early Intervention for Spinal Cord Injury with Human Induced Pluripotent Stem Cells Oligodendrocyte Progenitors Open

Angelo H. All, Payam Gharibani, Siddharth Gupta, Faith A. Bazley, Nikta Pashai , et al. · 2015

Induced pluripotent stem (iPS) cells are at the forefront of research in regenerative medicine and are envisaged as a source for personalized tissue repair and cell replacement therapy. Here, we demonstrate for the first time that oligoden…

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