Angie Kirchner
YOU?
Author Swipe
View article: SCoTCH-seq reveals that 5-hydroxymethylcytosine encodes regulatory information across DNA strands
SCoTCH-seq reveals that 5-hydroxymethylcytosine encodes regulatory information across DNA strands Open
In mammalian genomes, cytosine modifications form a layer of regulatory information alongside the genetic code. Decoding this information is crucial to our understanding of biology and disease. Established sequencing methods cannot simulta…
View article: G-quadruplex DNA structure is a positive regulator of <i>MYC</i> transcription
G-quadruplex DNA structure is a positive regulator of <i>MYC</i> transcription Open
DNA structure can regulate genome function. Four-stranded DNA G-quadruplex (G4) structures have been implicated in transcriptional regulation; however, previous studies have not directly addressed the role of an individual G4 within its en…
View article: 5‐Hydroxymethyl‐, 5‐Formyl‐ and 5‐Carboxydeoxycytidines as Oxidative Lesions and Epigenetic Marks
5‐Hydroxymethyl‐, 5‐Formyl‐ and 5‐Carboxydeoxycytidines as Oxidative Lesions and Epigenetic Marks Open
The four non‐canonical nucleotides in the human genome 5‐methyl‐, 5‐hydroxymethyl‐, 5‐formyl‐ and 5‐carboxydeoxycytidine (mdC, hmdC, fdC and cadC) form a second layer of epigenetic information that contributes to the regulation of gene exp…
View article: Oxidative and non-oxidative active turnover of genomic methylcytosine in distinct pluripotent states
Oxidative and non-oxidative active turnover of genomic methylcytosine in distinct pluripotent states Open
Epigenetic plasticity underpins cell potency, but the extent to which active turnover of DNA methylation contributes to such plasticity is not known and the underlying pathways are poorly understood. Here we use metabolic labelling with st…
View article: 5‐Formylcytosine Could Be a Semipermanent Base in Specific Genome Sites
5‐Formylcytosine Could Be a Semipermanent Base in Specific Genome Sites Open
5‐Formyl‐2′‐deoxycytosine (fdC) is a recently discovered epigenetic base in the genome of stem cells, with yet unknown functions. Sequencing data show that the base is enriched in CpG islands of promoters and hence likely involved in the r…