Angie Vreugdenhil
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View article: Rapid rewiring of an archaeal transcription factor function via flexible cis-trans interactions
Rapid rewiring of an archaeal transcription factor function via flexible cis-trans interactions Open
For microbial cells, an appropriate response to changing environmental conditions is critical for viability. Transcription regulatory proteins, or transcription factors (TFs) sense environmental signals to change gene expression. However, …
View article: <scp>TbsP</scp> and <scp>TrmB</scp> jointly regulate <i>gapII</i> to influence cell development phenotypes in the archaeon <i>Haloferax volcanii</i>
<span>TbsP</span> and <span>TrmB</span> jointly regulate <i>gapII</i> to influence cell development phenotypes in the archaeon <i>Haloferax volcanii</i> Open
Microbial cells must continually adapt their physiology in the face of changing environmental conditions. Archaea living in extreme conditions, such as saturated salinity, represent important examples of such resilience. The model salt‐lov…
View article: The Hypersaline Archaeal Histones HpyA and HstA Are DNA Binding Proteins That Defy Categorization According to Commonly Used Functional Criteria
The Hypersaline Archaeal Histones HpyA and HstA Are DNA Binding Proteins That Defy Categorization According to Commonly Used Functional Criteria Open
Most cells in eukaryotic species—from yeast to humans—possess histone proteins that pack and unpack DNA in response to environmental cues. These essential proteins regulate genes necessary for important cellular processes, including develo…
View article: Data and scripts from: Copy number variation is associated with gene expression change in archaea
Data and scripts from: Copy number variation is associated with gene expression change in archaea Open
Genomic instability, although frequently deleterious, is also an important mechanism for microbial adaptation to environmental change. Although widely studied in bacteria, in archaea the effect of genomic instability on organism phenotypes…
View article: Comparative analysis of genome-wide protein-DNA interactions across domains of life reveals unique binding patterns for hypersaline archaeal histones
Comparative analysis of genome-wide protein-DNA interactions across domains of life reveals unique binding patterns for hypersaline archaeal histones Open
DNA-binding proteins with roles in chromatin architecture and transcriptional regulation are present in all three domains of life. Histones package DNA and regulate gene expression in eukaryotes, and find their evolutionary origin in the d…
View article: Copy number variation is associated with gene expression change in archaea
Copy number variation is associated with gene expression change in archaea Open
Genomic instability, although frequently deleterious, is also an important mechanism for microbial adaptation to environmental change. Although widely studied in bacteria, in archaea the effect of genomic instability on organism phenotypes…
View article: Additional file 1: Table S1. of Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-κB binding that is linked to immune phenotypes
Additional file 1: Table S1. of Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-κB binding that is linked to immune phenotypes Open
Showing number of VDR peaks and number of Lead and LD SNPs overlapping with VDR peaks in different cell line models. Number of peaks for individual VDR ChIP-seq data and the number of Lead SNPs along with associated LD SNPs which fall unde…