Angus A. Wilfong
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View article: Time to treatment in pediatric patients with repeated episodes of status epilepticus
Time to treatment in pediatric patients with repeated episodes of status epilepticus Open
View article: Time to Treatment in Pediatric Patients with Repeated Episodes of Status Epilepticus
Time to Treatment in Pediatric Patients with Repeated Episodes of Status Epilepticus Open
Objective To compare pediatric patients who presented with repeated status epilepticus episodes to patients with a single episode of status epilepticus and identify distinguishing clinical factors. Methods Retrospective analysis of a multi…
View article: Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation
Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation Open
Background Mutations in the NMDA receptor are known to disrupt glutamatergic signaling crucial for early neurodevelopment, often leading to severe global developmental delay/intellectual disability, epileptic encephalopathy, and cerebral p…
View article: Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children
Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children Open
This study provides Class II evidence that patient and clinical factors may predict RSE in children with convulsive seizures.
View article: Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development
Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development Open
View article: Additional file 4 of Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation
Additional file 4 of Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation Open
Supplementary Material 4
View article: Additional file 3 of Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation
Additional file 3 of Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation Open
Supplementary Material 3
View article: Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation
Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation Open
Background Mutations in the NMDA receptor are known to disrupt glutamatergic signaling crucial for early neurodevelopment, often leading to severe global developmental delay/intellectual disability, epileptic encephalopathy, and cerebral p…
View article: Is Resting State Functional MRI Effective Connectivity in Movement Disorders Helpful? A Focused Review Across Lifespan and Disease
Is Resting State Functional MRI Effective Connectivity in Movement Disorders Helpful? A Focused Review Across Lifespan and Disease Open
In the evolving modern era of neuromodulation for movement disorders in adults and children, much progress has been made recently characterizing the human motor network (MN) with potentially important treatment implications. Herein is a fo…
View article: Is Resting State Functional MRI Effective Connectivity in Movement Disorders Helpful? A Focused Review Across Lifespan and Disease
Is Resting State Functional MRI Effective Connectivity in Movement Disorders Helpful? A Focused Review Across Lifespan and Disease Open
In the evolving modern era of neuromodulation for movement disorders in adults and children, much progress has been made recently characterizing the human motor network (MN) with potentially important treatment implications. Herein is a fo…
View article: Dynamic Resting State Motor Network Connectivity of Neurotypical Children, the Groundwork for Network-Guided Therapy in Childhood Movement Disorders
Dynamic Resting State Motor Network Connectivity of Neurotypical Children, the Groundwork for Network-Guided Therapy in Childhood Movement Disorders Open
Background Normative childhood motor network resting-state fMRI effective connectivity is undefined, yet necessary for translatable dynamic resting-state network informed treatments in pediatric movement disorders. Method Cross-spectral dy…
View article: Benzodiazepine administration patterns before escalation to second‐line medications in pediatric refractory convulsive status epilepticus
Benzodiazepine administration patterns before escalation to second‐line medications in pediatric refractory convulsive status epilepticus Open
Objective This study was undertaken to evaluate benzodiazepine (BZD) administration patterns before transitioning to non‐BZD antiseizure medication (ASM) in pediatric patients with refractory convulsive status epilepticus (rSE). Methods Th…
View article: Factors associated with long‐term outcomes in pediatric refractory status epilepticus
Factors associated with long‐term outcomes in pediatric refractory status epilepticus Open
Objective This study was undertaken to describe long‐term clinical and developmental outcomes in pediatric refractory status epilepticus (RSE) and identify factors associated with new neurological deficits after RSE. Methods We performed r…
View article: Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort)
Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort) Open
Objective We aimed to characterize the clinical profile and outcomes of new onset refractory status epilepticus (NORSE) in children, and investigated the relationship between fever onset and status epilepticus (SE). Methods Patients with r…
View article: Efficacy and tolerability of a whey-based, medium-chain triglyceride–enhanced ketogenic formula in children with refractory epilepsy: A retrospective study
Efficacy and tolerability of a whey-based, medium-chain triglyceride–enhanced ketogenic formula in children with refractory epilepsy: A retrospective study Open
The WBME ketogenic formula appears to be effective and well tolerated by pediatric patients with refractory epilepsy.
View article: Multicenter Research Data of Epilepsy Management in Patients With Sturge-Weber Syndrome
Multicenter Research Data of Epilepsy Management in Patients With Sturge-Weber Syndrome Open
View article: First-line medication dosing in pediatric refractory status epilepticus
First-line medication dosing in pediatric refractory status epilepticus Open
This study provides Class III evidence that patients with RSE who present with male sex, older age, no prior diagnosis of epilepsy, and delayed BZD treatment are more likely to receive low total BZD doses. This study provides Class III evi…
View article: Association of guideline publication and delays to treatment in pediatric status epilepticus
Association of guideline publication and delays to treatment in pediatric status epilepticus Open
Publication of evidence on delays in time to treatment was not associated with improvements in time to treatment of rSE, although it was associated with an increase in the proportion of patients who received at least 1 BZD before hospital …
View article: Resting-state functional MRI connectivity impact on epilepsy surgery plan and surgical candidacy: prospective clinical work
Resting-state functional MRI connectivity impact on epilepsy surgery plan and surgical candidacy: prospective clinical work Open
OBJECTIVE The authors’ goal was to prospectively quantify the impact of resting-state functional MRI (rs-fMRI) on pediatric epilepsy surgery planning. METHODS Fifty-one consecutive patients (3 months to 20 years old) with intractable epile…
View article: Resting-state fMRI in disorders of consciousness to facilitate early therapeutic intervention
Resting-state fMRI in disorders of consciousness to facilitate early therapeutic intervention Open
Whole-brain analysis of resting-state functional MRI by independent component analysis may aid in accurate diagnosis of disorders of consciousness, prognosis of coma following an acute brain injury, as well as provide an opportunity for ea…
View article: Network‐targeted approach and postoperative resting‐state functional magnetic resonance imaging are associated with seizure outcome
Network‐targeted approach and postoperative resting‐state functional magnetic resonance imaging are associated with seizure outcome Open
Objective Postoperative resting‐state functional magnetic resonance imaging (MRI) in children with intractable epilepsy has not been quantified in relation to seizure outcome. Therefore, its value as a biomarker for epileptogenic pathology…
View article: Quality of Life in Children With Sturge-Weber Syndrome
Quality of Life in Children With Sturge-Weber Syndrome Open
View article: Physical and Family History Variables Associated With Neurological and Cognitive Development in Sturge-Weber Syndrome
Physical and Family History Variables Associated With Neurological and Cognitive Development in Sturge-Weber Syndrome Open
View article: Hypothesis: Presymptomatic treatment of Sturge-Weber Syndrome With Aspirin and Antiepileptic Drugs May Delay Seizure Onset
Hypothesis: Presymptomatic treatment of Sturge-Weber Syndrome With Aspirin and Antiepileptic Drugs May Delay Seizure Onset Open
View article: Language lateralization with resting-state and task-based functional MRI in pediatric epilepsy
Language lateralization with resting-state and task-based functional MRI in pediatric epilepsy Open
OBJECTIVE Determining language laterality in patients with intractable epilepsy is important in operative planning. Wada testing is the gold standard, but it has a risk of stroke. Both Wada and task-based functional MRI (tb-fMRI) require p…
View article: Subcentimeter epilepsy surgery targets by resting state functional magnetic resonance imaging can improve outcomes in hypothalamic hamartoma
Subcentimeter epilepsy surgery targets by resting state functional magnetic resonance imaging can improve outcomes in hypothalamic hamartoma Open
Summary Objective The purpose of this study is to investigate the outcomes of epilepsy surgery targeting the subcentimeter‐sized resting state functional magnetic resonance imaging (rs‐fMRI) epileptogenic onset zone (EZ) in hypothalamic ha…
View article: Open-label use of highly purified CBD (Epidiolex®) in patients with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromes
Open-label use of highly purified CBD (Epidiolex®) in patients with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromes Open
This open-label drug trial provides class III evidence for the long-term safety and efficacy of CBD administration in patients with treatment-resistant epilepsy (TRE) associated with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose…
View article: Factors associated with treatment delays in pediatric refractory convulsive status epilepticus
Factors associated with treatment delays in pediatric refractory convulsive status epilepticus Open
Intermittent rSE and out-of-hospital rSE onset are independently associated with longer delays to administration of the first BZD and the first non-BZD AED in pediatric rSE. These factors identify potential targets for intervention to redu…
View article: Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome
Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome Open
This study provides Class I evidence that for children with Dravet syndrome, CBD resulted in more AEs than placebo but was generally well-tolerated.
View article: Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus
Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus Open
Among pediatric patients with RCSE, an untimely first-line benzodiazepine treatment is independently associated with a higher frequency of death, use of continuous infusions, longer convulsion duration, and more frequent hypotension. Resul…