Angus D. Macaulay
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View article: Relationship of quantitative reverse transcription polymerase chain reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome identifies mouse preimplantation embryo reference genes
Relationship of quantitative reverse transcription polymerase chain reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome identifies mouse preimplantation embryo reference genes Open
Numerous reference genes for use with quantitative reverse transcription polymerase chain reaction (RT-qPCR) have been used for oocytes, eggs, and preimplantation embryos. However, none are actually suitable because of their large variatio…
View article: Roles of the cumulus–oocyte transzonal network and the Fragile X protein family in oocyte competence
Roles of the cumulus–oocyte transzonal network and the Fragile X protein family in oocyte competence Open
In brief RNA granules travel through the cumulus cell network of transzonal projections which is associated with oocyte developmental competence, and RNA packaging involves RNA-binding proteins of the Fragile X protein family. Abstract The…
View article: SWI/SNF chromatin remodeling subunit<i>Smarca4</i>/BRG1 is essential for female fertility
SWI/SNF chromatin remodeling subunit<i>Smarca4</i>/BRG1 is essential for female fertility Open
Mammalian folliculogenesis is a complex process that involves the regulation of chromatin structure for gene expression and oocyte meiotic resumption. The SWI/SNF complex is a chromatin remodeler using either Brahma-regulated gene 1 (BRG1)…
View article: Initial detachment of the mouse oocyte from the zona pellucida is mediated by metallopeptidase activity
Initial detachment of the mouse oocyte from the zona pellucida is mediated by metallopeptidase activity Open
The fully grown mammalian oocyte is tightly attached to its extracellular matrix shell, the zona pellucida (ZP), but the oocyte detaches from the ZP shortly after ovulation is signaled. The mechanism by which the oocyte detaches from the Z…
View article: Mammalian cumulus-oocyte complex communication: a dialog through long and short distance messaging
Mammalian cumulus-oocyte complex communication: a dialog through long and short distance messaging Open
Communications are crucial to ovarian follicle development and to ovulation, and while both folliculogenesis and oogenesis are distinct processes, they share highly interdependent signaling pathways. Signals from distant organs such as the…
View article: Multiple Mechanisms Cooperate to Constitutively Exclude the Transcriptional Co-Activator YAP from the Nucleus During Murine Oogenesis1
Multiple Mechanisms Cooperate to Constitutively Exclude the Transcriptional Co-Activator YAP from the Nucleus During Murine Oogenesis1 Open
Reproduction depends on the generation of healthy oocytes. Improving therapeutic strategies to prolong or rescue fertility depends on identifying the inter- and intracellular mechanisms that direct oocyte development under physiological co…
View article: Cumulus Cell Transcripts Transit to the Bovine Oocyte in Preparation for Maturation1
Cumulus Cell Transcripts Transit to the Bovine Oocyte in Preparation for Maturation1 Open
So far, the characteristics of a good quality egg have been elusive, similar to the nature of the physiological, cellular, and molecular cues leading to its production both in vivo and in vitro. Current understanding highlights a strong an…