Angus Nichols
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View article: Drosophila Col4a1 Glycine mutations highlight allelic heterogeneity and mechanistic pleiotropy
Drosophila Col4a1 Glycine mutations highlight allelic heterogeneity and mechanistic pleiotropy Open
Collagen IV (Col4) is a heterotrimer containing a triple helical domain broken up by short interruptions. Mutation of Glycine residues within the Glycine-X-Y triple helical repeat leads to genetically dominant disease in humans that affect…