Anika Bluemke
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View article: The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations
The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations Open
Tauopathies such as Alzheimer's disease, frontotemporal dementia with Parkinsonism, and other neurodegenerative diseases are classified as protein folding diseases because they share amyloid fibrils as a hallmark. Typically, amyloid fibril…
View article: A non-autonomous protein quality control mechanism targeting tau aggregate propagation
A non-autonomous protein quality control mechanism targeting tau aggregate propagation Open
SUMMARY Tauopathies such as Alzheimer’s disease, frontotemporal dementia with Parkinsonism, and other neurodegenerative disorders are characterized by the spread of tau pathology from an initial brain region to neuroanatomically connected …
View article: An allosteric HTRA1-calpain 2 complex with restricted activation profile
An allosteric HTRA1-calpain 2 complex with restricted activation profile Open
Significance Classic serine proteases are synthesized as inactive precursors that are proteolytically processed, resulting in irreversible activation. We report an alternative and reversible mechanism of activation that is executed by an i…
View article: Emergence of CD43-Expressing Hematopoietic Progenitors from Human Induced Pluripotent Stem Cells
Emergence of CD43-Expressing Hematopoietic Progenitors from Human Induced Pluripotent Stem Cells Open
Background: The ex vivo generation of human hematopoietic stem cells (HSCs) with long-term repopulating capacity and multi-lineage differentiation potential represents the holy grail of hematopoiesis research. In principle, human induced p…