Anika Mueller
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View article: Associations between blood cholinesterase activity and postoperative basal forebrain cholinergic system atrophy: Results from the BioCog cohort study
Associations between blood cholinesterase activity and postoperative basal forebrain cholinergic system atrophy: Results from the BioCog cohort study Open
OBJECTIVE Structural and functional metabolism are closely linked in the cholinergic system, and associations between cholinergic neurotransmission and atrophy of cholinergic nuclei, i.e., the nucleus basalis of Meynert (NBM), have been de…
View article: Perioperative Dynamics of Autoantibodies Against Neurotransmitter Receptors in Liver Surgery: A Secondary Analysis of the PHYDELIO Trial
Perioperative Dynamics of Autoantibodies Against Neurotransmitter Receptors in Liver Surgery: A Secondary Analysis of the PHYDELIO Trial Open
Background Postoperative delirium (POD) is a common neurocognitive complication following major surgery, particularly in older adults and those undergoing liver resections. Neuroinflammatory mechanisms are considered central to its pathoph…
View article: Modification in ICU design may influence circadian serum cholinesterase activities: a proof-of-concept pilot study
Modification in ICU design may influence circadian serum cholinesterase activities: a proof-of-concept pilot study Open
Background Deficits in cholinergic function are assumed to cause cognitive decline. Studies have demonstrated that changes in serum cholinesterase activities are associated with a higher incidence of delirium in critically ill patients. Ad…
View article: Systemic corticosteroids for the treatment of COVID-19
Systemic corticosteroids for the treatment of COVID-19 Open
View article: Colchicine for the treatment of COVID-19
Colchicine for the treatment of COVID-19 Open
View article: Perceptions and experiences with eating disorder treatment in the first year of COVID-19: A longitudinal qualitative analysis
Perceptions and experiences with eating disorder treatment in the first year of COVID-19: A longitudinal qualitative analysis Open
Objective: The COVID-19 pandemic created significant challenges in accessing and receiving treatment for individuals with eating disorders (EDs). The purpose of this study is to explore perceptions of and experiences with ED treatment duri…
View article: Automated Monitoring of Adherence to Evidenced-Based Clinical Guideline Recommendations: Design and Implementation Study
Automated Monitoring of Adherence to Evidenced-Based Clinical Guideline Recommendations: Design and Implementation Study Open
Background Clinical practice guidelines are systematically developed statements intended to optimize patient care. However, a gapless implementation of guideline recommendations requires health care personnel not only to be aware of the re…
View article: Automated Monitoring of Adherence to Evidenced-Based Clinical Guideline Recommendations: Design and Implementation Study (Preprint)
Automated Monitoring of Adherence to Evidenced-Based Clinical Guideline Recommendations: Design and Implementation Study (Preprint) Open
BACKGROUND Clinical practice guidelines are systematically developed statements intended to optimize patient care. However, a gapless implementation of guideline recommendations requires health care personnel not only to be aware of the r…
View article: Colchicine for the treatment of COVID-19
Colchicine for the treatment of COVID-19 Open
Based on the current evidence, in people hospitalised with moderate to severe COVID-19 the use of colchicine probably has little to no influence on mortality or clinical progression in comparison to placebo or standard care alone. We do no…
View article: Dexmedetomidine Induces Low Patient State Indices While Preventing the Development of Postoperative Delirium in Older Patients Undergoing General Anesthesia - A Secondary Analysis of a Randomized Controlled Trial (NEUPRODEX)
Dexmedetomidine Induces Low Patient State Indices While Preventing the Development of Postoperative Delirium in Older Patients Undergoing General Anesthesia - A Secondary Analysis of a Randomized Controlled Trial (NEUPRODEX) Open
Background: Dexmedetomidine may have a delirium preventive effect in high-risk surgical patients. Accurate frontal EEG-guided anesthesia can decrease the incidence of postoperative delirium by avoiding too deep anesthesia. Aim of our study…
View article: A Quantitative Study for Evaluating Risk Factors in Routine Perioperative Assessment During Elective Bariatric Surgery Regarding the Development of Postoperative Delirium
A Quantitative Study for Evaluating Risk Factors in Routine Perioperative Assessment During Elective Bariatric Surgery Regarding the Development of Postoperative Delirium Open
Background: Postoperative delirium (POD) is associated with long term physical and cognitive impairment. Identification of eligible biomarkers is desirable. In this subanalysis of data collected during the prospective observational CESARO …
View article: Systemic corticosteroids for the treatment of COVID-19
Systemic corticosteroids for the treatment of COVID-19 Open
Moderate-certainty evidence shows that systemic corticosteroids probably slightly reduce all-cause mortality in people hospitalised because of symptomatic COVID-19. Low-certainty evidence suggests that there may also be a reduction in vent…
View article: Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Systemic corticosteroids for the treatment of COVID-19.
Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Systemic corticosteroids for the treatment of COVID-19. Open
Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Systemic corticosteroids for the treatment of COVID-19.
View article: Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Systemic corticosteroids for the treatment of COVID-19.
Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Systemic corticosteroids for the treatment of COVID-19. Open
Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Systemic corticosteroids for the treatment of COVID-19.
View article: Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Systemic corticosteroids for the treatment of COVID-19.
Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Systemic corticosteroids for the treatment of COVID-19. Open
Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Systemic corticosteroids for the treatment of COVID-19.
View article: Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Systemic corticosteroids for the treatment of COVID-19.
Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Systemic corticosteroids for the treatment of COVID-19. Open
Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Systemic corticosteroids for the treatment of COVID-19.
View article: Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Systemic corticosteroids for the treatment of COVID-19.
Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Systemic corticosteroids for the treatment of COVID-19. Open
Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Systemic corticosteroids for the treatment of COVID-19.
View article: The effect of peri‐operative dexmedetomidine on the incidence of postoperative delirium in cardiac and non‐cardiac surgical patients: a randomised, double‐blind placebo‐controlled trial
The effect of peri‐operative dexmedetomidine on the incidence of postoperative delirium in cardiac and non‐cardiac surgical patients: a randomised, double‐blind placebo‐controlled trial Open
Summary Delirium occurs commonly following major non‐cardiac and cardiac surgery and is associated with: postoperative mortality; postoperative neurocognitive dysfunction; increased length of hospital stay; and major postoperative complica…
View article: Postoperative anaemia might be a risk factor for postoperative delirium and prolonged hospital stay: A secondary analysis of a prospective cohort study
Postoperative anaemia might be a risk factor for postoperative delirium and prolonged hospital stay: A secondary analysis of a prospective cohort study Open
Background: Postoperative anaemia is a frequent surgical complication and in contrast to preoperative anaemia has not been validated in relation to mortality, morbidity and its associated health economic effect. Postoperative anaemia can p…
View article: Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) – short version
Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) – short version Open
In 2010, under the guidance of the DGAI (German Society of Anaesthesiology and Intensive Care Medicine) and DIVI (German Interdisciplinary Association for Intensive Care and Emergency Medicine), twelve German medical societies published th…