Explanipedia

CT Images of the Pancreas for Beginners Open

Yusuf Bayta, David C. Whitcomb, Anil K. Dasyam · 2025

Imaging is critical to determining the etiology and progression of pancreatic diseases. The most commonly utilized modality is computed tomography (CT), typically, contrast enhanced CT (CECT). Here we present a primer for health care provi…

Adrenal imaging features and associated pathologic diagnoses: A contemporary, longitudinal analysis Open

Kelly A. Stahl, Alaa Sada, Yusuf Baytar, Anil K. Dasyam, Jodi K. Maranchie , et al. · 2025

In this large, contemporary study, using adrenal lesion size >4.0 cm alone has low specificity (57%) in identifying malignant adrenal pathology and absolute contrast washout on adrenal protocol computed tomography can miss metastatic lesio…

Differential impact of recent heavy drinking on first and recurrent acute pancreatitis Open

Christie Y. Jeon, Yu Ye, Georgios I. Papachristou, James Buxbaum, Joseph R. Pisegna , et al. · 2025

Background While alcohol is known to sensitize the pancreas to acute injury, the role of short‐term episodic drinking in regular drinkers is unknown. Methods We conducted a case‐crossover study to (1) determine the hazardous period of drin…

Multiparametric <span>MRI</span> Scoring System of the Pancreas for the Diagnosis of Chronic Pancreatitis Open

Temel Tirkes, Dhiraj Yadav, Darwin L. Conwell, Xuandong Zhao, Anil K. Dasyam , et al. · 2024

Background Ductal features alone may not offer high diagnostic sensitivity or most accurate disease severity of chronic pancreatitis (CP). Purpose Diagnose CP based on multiparametric MRI and MRCP features. Study Type Prospective. Populati…

Natural history of spontaneous pancreatic portal vein fistulae: A systematic review of the literature Open

Natalie E. Griffin, Morgan Ferrell, Robert Feldman, Anil K. Dasyam, Adam Slivka , et al. · 2024

PPVF is a rare and potentially fatal condition, though rates of bleeding complication and death were relatively low in this population. High-quality observational studies are needed to better understand the pathophysiology and natural hist…

Diagnostic and Prognostic Biomarkers of Chronic Pancreatitis: A Conceptual Framework Based on the PRoBE Design Open

Dhiraj Yadav, Darwin L. Conwell, Stephen J. Pandol, Hanno Steen, Ziding Feng , et al. · 2024

Diagnosis of chronic pancreatitis using semi-quantitative MRI features of the pancreatic parenchyma: results from the multi-institutional MINIMAP study Open

Temel Tirkes, Dhiraj Yadav, Darwin L. Conwell, Paul R. Territo, Xuandong Zhao , et al. · 2023

RNA Sequencing Identifies Frequent Mitogen-activated Protein Kinase–associated Fusion Genes in Intraductal Tubulopapillary Neoplasms of the Pancreas Open

Jae W. Lee, Ralph H. Hruban, Lodewijk A.A. Brosens, Vincenzo Condello, Marina N. Nikiforova , et al. · 2023

Intraductal tubulopapillary neoplasms (ITPNs) of the pancreas are rare cystic precursor neoplasms to invasive pancreatic ductal adenocarcinoma (PDAC) and account for 3% of intraductal neoplasms of the pancreas. Originally reported by Yamag…

Quantitative MRI of chronic pancreatitis: results from a multi-institutional prospective study, magnetic resonance imaging as a non-invasive method for assessment of pancreatic fibrosis (MINIMAP) Open

Temel Tirkes, Dhiraj Yadav, Darwin L. Conwell, Paul R. Territo, Xuandong Zhao , et al. · 2022

T1 signal intensity ratio of the pancreas as an imaging biomarker for the staging of chronic pancreatitis Open

Temel Tirkes, Anil K. Dasyam, Zarine K. Shah, Evan L. Fogel, Santhi Swaroop Vege , et al. · 2022

Design and Rationale for the Use of Magnetic Resonance Imaging Biomarkers to Predict Diabetes After Acute Pancreatitis in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study Open

Temel Tirkes, Vernon M. Chinchilli, Ulaş Bağcı, Jason G. Parker, Xuandong Zhao , et al. · 2022

This core component of the Diabetes RElated to Acute pancreatitis and its Mechanisms (DREAM) study will examine the hypothesis that advanced magnetic resonance imaging (MRI) techniques can reflect underlying pathophysiologic changes and pr…

Noninvasive Imaging Prior to Biliary Interventions Open

Roberta Catania, Anil K. Dasyam, Frank H. Miller, Amir A. Borhani · 2021

Noninvasive imaging is a crucial and initial step in the diagnostic algorithm of patients with suspected biliary pathology and directs the subsequent diagnostic and therapeutic workup, including the endoluminal and percutaneous biliary int…

Role of standardized reporting and novel imaging markers in chronic pancreatitis Open

Temel Tirkes, Anil K. Dasyam, Zarine K. Shah, Evan L. Fogel · 2021

Purpose of review This article reviews recent efforts about standardized imaging features and reporting of chronic pancreatitis and recently published or ongoing imaging studies, which aim to establish novel imaging biomarkers for detectio…

Tumor Size Differences Between Preoperative Endoscopic Ultrasound and Postoperative Pathology for Neoadjuvant-Treated Pancreatic Ductal Adenocarcinoma Predict Patient Outcome Open

Rohit Das, Kevin McGrath, Natalie Seiser, Katelyn Smith, Shikhar Uttam , et al. · 2020

Imaging-Based Subtypes of Pancreatic Ductal Adenocarcinoma Exhibit Differential Growth and Metabolic Patterns in the Pre-Diagnostic Period: Implications for Early Detection Open

Mohamed Zaid, Dalia Elganainy, Prashant Dogra, Annie Dai, L. Widmann , et al. · 2020

Background Previously, we characterized subtypes of pancreatic ductal adenocarcinoma (PDAC) on computed-tomography (CT) scans, whereby conspicuous (high delta) PDAC tumors are more likely to have aggressive biology and poorer clinical outc…

Groove pancreatitis has a spectrum of severity and can be managed conservatively Open

Kohtaro Ooka, Harkirat Singh, Matthew Warndorf, Melissa Saul, Andrew D. Althouse , et al. · 2020

A Rare Complication of Chronic Pancreatitis Open

Anna Evans Phillips, Alessandro Paniccia, Anil K. Dasyam · 2020

Inter-observer variability of radiologists for Cambridge classification of chronic pancreatitis using CT and MRCP: results from a large multi-center study Open

Temel Tirkes, Zarine K. Shah, Naoki Takahashi, Joseph R. Grajo, Stephanie T. Chang , et al. · 2020

Hereditary and Sporadic Pancreatic Ductal Adenocarcinoma: Current Update on Genetics and Imaging Open

Ajaykumar C. Morani, Abdelrahman K. Hanafy, Nisha S. Ramani, Venkata S. Katabathina, Sireesha Yedururi , et al. · 2020

Pancreatic ductal adenocarcinoma (PDAC) is a genetically heterogeneous, biologically aggressive malignancy with a uniformly poor prognosis. While most pancreatic cancers arise sporadically, a small subset of PDACs develop in patients with …

Significance Of "Dominant" Uncinate Duct Dilatation In Ipmn: A New High-Risk Criterion Open

Samer AlMasri, Marco A. Zenati, Anil K. Dasyam, Aatur D. Singhi, K. Lee , et al. · 2020

Precision Medicine in Pancreatic Disease—Knowledge Gaps and Research Opportunities Open

Mark E. Lowe, Dana K. Andersen, Richard M. Caprioli, Jyoti S. Choudhary, Zobeida Cruz‐Monserrate , et al. · 2019

A workshop on research gaps and opportunities for Precision Medicine in Pancreatic Disease was sponsored by the National Institute of Diabetes and Digestive Kidney Diseases on July 24, 2019, in Pittsburgh. The workshop included an overview…

Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct Open

Aatur D. Singhi, Laura D. Wood, Emily Parks, Michael Torbenson, Matthäus Felsenstein , et al. · 2019

We identified fusions in PRKACA and PRKACB genes in pancreatic and biliary IOPNs, as well as in PDACs and pancreatic cyst fluid and bile duct cells from the same patients. We did not identify these gene fusions in 126 control pancreatobili…

Computed tomography based scoring system in a prospectively ascertained cohort of patients with chronic pancreatitis Open

Anil K. Dasyam, Kishore Vipperla, Adam Slivka, Gong Tang, Georgios I. Papachristou , et al. · 2019

Cross-sectional imaging-based severity scoring of chronic pancreatitis: why it is necessary and how it can be done Open

Anil K. Dasyam, Zarine K. Shah, Temel Tirkes, Navya Dasyam, Amir A. Borhani · 2019

Su1432 – The Clinical Spectrum of Groove Pancreatitis is Much Wider Than It is Believed Open

Kohtaro Ooka, Harkirat Singh, Matthew Warndorf, Andrew D. Althouse, Anil K. Dasyam , et al. · 2019

Integrating next-generation sequencing to endoscopic retrograde cholangiopancreatography (ERCP)-obtained biliary specimens improves the detection and management of patients with malignant bile duct strictures Open

Aatur D. Singhi, Marina N. Nikiforova, Jennifer Chennat, Georgios I. Papachristou, Asif Khalid , et al. · 2019

Objective Despite improvements in imaging, serum CA19-9 and pathological evaluation, differentiating between benign and malignant bile duct strictures remains a diagnostic conundrum. Recent developments in next-generation sequencing (NGS) …

Chronic Pancreatitis with Spontaneously Disappearing Calcifications Open

Scott Friedberg, Adam Slivka, Anil K. Dasyam, Dhiraj Yadav · 2018

Pancreatic calcifications, exocrine insufficiency, and endocrine insufficiency are hallmarks of chronic pancreatitis, and their prevalence increases with the duration of disease. We present a case of chronic pancreatitis in which a dramati…

Chronic Pancreatitis with Spontaneously Disappearing Calcifications Open

Scott Friedberg, Adam Slivka, Anil K. Dasyam, Dhiraj Yadav · 2018

Pancreatic calcifications, exocrine insufficiency, and endocrine insufficiency are hallmarks of chronic pancreatitis, and their prevalence increases with the duration of disease. We present a case of chronic pancreatitis in which a dramati…

Chronic Pancreatitis with Spontaneously Disappearing Calcifications Open

Scott Friedberg, Adam Slivka, Anil K. Dasyam, Dhiraj Yadav · 2018

Pancreatic calcifications, exocrine insufficiency, and endocrine insufficiency are hallmarks of chronic pancreatitis, and their prevalence increases with the duration of disease. We present a case of chronic pancreatitis in which a dramati…

Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia Open

Aatur D. Singhi, Kevin McGrath, Randall E. Brand, Asif Khalid, Herbert J. Zeh , et al. · 2017

Objective DNA-based testing of pancreatic cyst fluid (PCF) is a useful adjunct to the evaluation of pancreatic cysts (PCs). Mutations in KRAS / GNAS are highly specific for intraductal papillary mucinous neoplasms (IPMNs) and mucinous cyst…

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