Anil K. Chauhan
YOU?
Author Swipe
View article: Platelet dysfunction in Ehlers–Danlos syndrome is associated with low GPVI and PAR1 expression on platelets
Platelet dysfunction in Ehlers–Danlos syndrome is associated with low GPVI and PAR1 expression on platelets Open
Introduction: People with Ehlers–Danlos syndrome (EDS) are at an increased risk for hemorrhagic events, which can range from minor bruising to life-threatening bleeding episodes. Although prior research has suggested the presence of platel…
View article: HTRS2025.O8A.2 Abstract Travel Award Unraveling Platelet Dysfunction in Ehlers-Danlos Syndrome: Linking Megakaryocyte Abnormalities to Hemorrhagic Risk
HTRS2025.O8A.2 Abstract Travel Award Unraveling Platelet Dysfunction in Ehlers-Danlos Syndrome: Linking Megakaryocyte Abnormalities to Hemorrhagic Risk Open
View article: Pyruvate kinase M2 promotes venous thrombosis by enhancing SNAP23-mediated platelet exocytosis and consequent NETosis
Pyruvate kinase M2 promotes venous thrombosis by enhancing SNAP23-mediated platelet exocytosis and consequent NETosis Open
Little is known about the role of metabolic regulatory mechanisms in the pathobiology of deep vein thrombosis (DVT). Recent studies have demonstrated the involvement of the metabolic enzyme pyruvate kinase M2 (PKM2) in platelet function; h…
View article: Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP‐Ribose) Polymerase Inhibitor Veliparib
Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP‐Ribose) Polymerase Inhibitor Veliparib Open
Background The Stroke Preclinical Assessment Network tested 6 therapeutic interventions initiated at the time of reperfusion after focal ischemic stroke in young mice, aging mice, obese mice, and spontaneously hypertensive rats. This rando…
View article: An Assessment of Morbidity Pattern among Rural Geriatric Population of Field Practice Area of MMIMSR, Mullana, Ambala District, Haryana
An Assessment of Morbidity Pattern among Rural Geriatric Population of Field Practice Area of MMIMSR, Mullana, Ambala District, Haryana Open
View article: Methodological framework and unified metrics for thrombus resolution analysis in the mouse inferior vena cava stenosis model
Methodological framework and unified metrics for thrombus resolution analysis in the mouse inferior vena cava stenosis model Open
View article: Methods for randomized, blinded, controlled evaluation of putative disease interventions in multi-laboratory, preclinical assessment networks
Methods for randomized, blinded, controlled evaluation of putative disease interventions in multi-laboratory, preclinical assessment networks Open
Science faces a reproducibility crisis, and public trust in science suffers when large clinical trials—qualified by promising preclinical studies—fail. While some clinical trial designs may have been inadequate, preclinical assessments of …
View article: Imbalanced VWF-ADAMTS13 axis contributes to the detrimental impact of a preceding respiratory tract infection on stroke
Imbalanced VWF-ADAMTS13 axis contributes to the detrimental impact of a preceding respiratory tract infection on stroke Open
Respiratory tract infections (RTIs) caused by bacteria or viruses are associated with stroke severity. Recent studies have revealed an imbalance in the von Willebrand factor (VWF)–ADAMTS13 (a disintegrin and metalloproteinase with thrombos…
View article: Cerebroprotective action of butylphthalide in acute ischemic stroke: Potential role of Nrf2/HO-1 signaling pathway
Cerebroprotective action of butylphthalide in acute ischemic stroke: Potential role of Nrf2/HO-1 signaling pathway Open
View article: Genetic ablation of myeloid integrin α9 attenuates early atherosclerosis
Genetic ablation of myeloid integrin α9 attenuates early atherosclerosis Open
Integrin α9β1 is known to stabilize leukocyte adhesion to the activated endothelium. We determined the role of myeloid cell α9β1 in early atherosclerosis in two models: α9Mye-KOApoe−/− or the Ldlr−/− mice transplanted with bone marrow (BM)…
View article: Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial
Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial Open
BACKGROUND: The SPAN trial (Stroke Preclinical Assessment Network) is the largest preclinical study testing acute stroke interventions in experimental focal cerebral ischemia using endovascular filament middle cerebral artery occlusion (MC…
View article: Deletion of pyruvate dehydrogenase kinases reduces susceptibility to deep vein thrombosis in mice
Deletion of pyruvate dehydrogenase kinases reduces susceptibility to deep vein thrombosis in mice Open
Neutrophils contribute to deep vein thrombosis (DVT) by releasing prothrombotic neutrophil extracellular traps (NETs). NET formation (known as NETosis) is an energy-intensive process that requires an increased rate of aerobic glycolysis. T…
View article: Super-specialty Medical Teleconsultations to Remote Areas of Ladakh, India via E-Sanjeevani under Hub-and-Spoke Model: A Pilot Study
Super-specialty Medical Teleconsultations to Remote Areas of Ladakh, India via E-Sanjeevani under Hub-and-Spoke Model: A Pilot Study Open
Objectives: To assess the feasibility, spectrum, outcomes and challenges of delivering super-specialty consultations to remote areas of the Union Territory (UT) of Ladakh through telemedicine. Design: Prospective, observational (descriptiv…
View article: Role of Platelet-rich Plasma in Unexplained Recurrent Implantation Failure – A Systematic Review and Meta-analysis of Randomised Control Trials
Role of Platelet-rich Plasma in Unexplained Recurrent Implantation Failure – A Systematic Review and Meta-analysis of Randomised Control Trials Open
A BSTRACT Background: Recurrent implantation failure (RIF) is a challenging clinical situation and various strategies have been tried to improve the pregnancy rate in RIF. Platelet-rich plasma (PRP), which is obtained from the autologous b…
View article: Platelet Metabolic Profiling Reveals Glycolytic and 1-Carbon Metabolites Are Essential for GP VI–Stimulated Human Platelets—Brief Report
Platelet Metabolic Profiling Reveals Glycolytic and 1-Carbon Metabolites Are Essential for GP VI–Stimulated Human Platelets—Brief Report Open
BACKGROUND: Evolving evidence suggests that besides signaling pathways, platelet activation involves a complex interplay between metabolic pathways to support thrombus growth. Selective targeting of metabolic checkpoints may inhibit platel…
View article: Uric Acid
Uric Acid Open
Uric acid (UA) is a strong endogenous antioxidant that neutralizes the toxicity of peroxynitrite and other reactive species on the neurovascular unit generated during and after acute brain ischemia. The realization that a rapid reduction o…
View article: Metabolic targeting of platelets to combat thrombosis: dawn of a new paradigm?
Metabolic targeting of platelets to combat thrombosis: dawn of a new paradigm? Open
Current antithrombotic therapies used in clinical settings target either the coagulation pathways or platelet activation receptors (P2Y12 or GPIIb/IIIa), as well as the cyclooxygenase (COX) enzyme through aspirin. However, they are associa…
View article: Targeting Neutrophil α9 Improves Functional Outcomes After Stroke in Mice With Obesity-Induced Hyperglycemia
Targeting Neutrophil α9 Improves Functional Outcomes After Stroke in Mice With Obesity-Induced Hyperglycemia Open
BACKGROUND: Obesity-induced hyperglycemia is a significant risk factor for stroke. Integrin α9β1 is expressed on neutrophils and stabilizes adhesion to the endothelium via ligands, including Fn-EDA (fibronectin containing extra domain A) a…
View article: P-294 The impact of audit in embryology laboratory and its outcome - A multicentric study
P-294 The impact of audit in embryology laboratory and its outcome - A multicentric study Open
Study question Would establishing an audit division in the embryology department of a well-organized multicentric IVF chain improve compliance thereby improving laboratory Key Performing Indicators (KPIs)? Summary answer The internal audit…
View article: Supplementary Methods from A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma
Supplementary Methods from A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma Open
Additional methods
View article: Data from A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma
Data from A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma Open
Purpose:Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with variable presentations and natural histories of disease. We hypothesized that different morphologic characteristics of PDAC tumors on diagnostic computed tomog…
View article: Supplementary Tables and Figures from A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma
Supplementary Tables and Figures from A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma Open
Includes Supplementary Tables S1 through S9, and Supplementary Figures S1 through S12
View article: Supplementary Movie (low delta) from A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma
Supplementary Movie (low delta) from A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma Open
Mathematical model simulation of low delta tumor growth (lambda = 0.2)
View article: Data from A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma
Data from A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma Open
Purpose:Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with variable presentations and natural histories of disease. We hypothesized that different morphologic characteristics of PDAC tumors on diagnostic computed tomog…
View article: Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis
Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis Open
Resting platelets rely on oxidative phosphorylation (OXPHOS) and aerobic glycolysis (conversion of glucose to lactate in the presence of oxygen) for their energy requirements. In contrast, platelet activation exhibits an increased rate of …
View article: Medicinal and therapeutic properties of garlic, garlic essential oil, and garlic-based snack food: An updated review
Medicinal and therapeutic properties of garlic, garlic essential oil, and garlic-based snack food: An updated review Open
Garlic ( Allium sativum ) is an edible tuber belonging to the family Liliaceae. It has been used since ancient times as a spice to enhance the sensory characteristics of food and as a household remedy for the treatment of a variety of ailm…
View article: Is Neck Pain Related to Sagittal Head and Neck Posture?: A Systematic Review and Meta-analysis
Is Neck Pain Related to Sagittal Head and Neck Posture?: A Systematic Review and Meta-analysis Open
View article: Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial
Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial Open
The Stroke Preclinical Assessment Network (SPAN) is a multicenter preclinical trial platform using rodent models of transient focal cerebral ischemia to address translational failure in experimental stroke. In addition to centralized rando…
View article: Cost-Effectiveness of Currently Available Diagnostic Tools for Diagnosis of Pediatric Tuberculosis Under National Tuberculosis Elimination Program
Cost-Effectiveness of Currently Available Diagnostic Tools for Diagnosis of Pediatric Tuberculosis Under National Tuberculosis Elimination Program Open
In India, children do not get diagnosed with tuberculosis (TB) for reasons such as lack of screening modality at the health-care settings, inadequate sputum sample, and low detection rate. This study aims to assess various modalities for d…
View article: Role of endotracheal tube culture or aspirate culture in identifying mechanically ventilated patients at risk for ventilator-associated pneumonia in neonatal intensive care unit at a tertiary care centre
Role of endotracheal tube culture or aspirate culture in identifying mechanically ventilated patients at risk for ventilator-associated pneumonia in neonatal intensive care unit at a tertiary care centre Open
Background: Ventilator-associated pneumonia (VAP) is the second most common hospital-acquired infection in Neonatal intensive care units (NICU). The standard methods of diagnosis are not popular because of their invasive nature and cost. E…