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View article: Gonadal Hormone Status Dictates Neurobehavioral, Metabolic and Immunological Benefits of Ketogenic Diet in Female Mice through Gut-Metabolic-Brain Axis
Gonadal Hormone Status Dictates Neurobehavioral, Metabolic and Immunological Benefits of Ketogenic Diet in Female Mice through Gut-Metabolic-Brain Axis Open
The ketogenic diet (KD) is recognized for its broad therapeutic potential across metabolic, neurological, immunological, and aging-related domains; however, its efficacy and durability in females remain underexplored. This study investigat…
View article: PILRA regulates microglial immunometabolism to reduce disease pathology as a candidate therapeutic target for Alzheimer’s disease
PILRA regulates microglial immunometabolism to reduce disease pathology as a candidate therapeutic target for Alzheimer’s disease Open
The Alzheimer’s disease (AD) genetic landscape identified microglia as a key disease-modifying cell type. A known AD protective variant in paired immunoglobulin-like type 2 receptor alpha (PILRA), shown to reduce risk in APOE4 carriers, is…
View article: Neuroimmunometabolism: how metabolism orchestrates immune response in healthy and diseased brain
Neuroimmunometabolism: how metabolism orchestrates immune response in healthy and diseased brain Open
Neuroimmunometabolism describes how neuroimmune cells, such as microglia, adapt their intracellular metabolic pathways to alter their immune functions in the central nervous system (CNS). Emerging evidence indicates that neurons also orche…
View article: Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic Open
View article: A brain penetrant progranulin biotherapeutic rescues lysosomal and inflammatory phenotypes in the brain of <i>GRN</i> knockout mice
A brain penetrant progranulin biotherapeutic rescues lysosomal and inflammatory phenotypes in the brain of <i>GRN</i> knockout mice Open
Background Heterozygous loss of function (LOF) mutations in GRN cause frontotemporal dementia (FTD), a neurodegenerative disorder associated with lysosomal dysfunction, TDP‐43 pathology and inflammation in the CNS. Additionally, homozygous…
View article: Differential activation of Gsk-3β in the cortex and the hippocampus induces cognitive and behavioural impairments in middle-aged ovariectomized rat
Differential activation of Gsk-3β in the cortex and the hippocampus induces cognitive and behavioural impairments in middle-aged ovariectomized rat Open
View article: Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic Open
View article: Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila
Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila Open
View article: Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster
Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster Open
View article: Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster
Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster Open
View article: Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality
Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality Open
Alterations in the composition of the intestinal microbiota have been correlated with aging and measures of frailty in the elderly. However, the relationships between microbial dynamics, age-related changes in intestinal physiology, and or…