Omshree Shetty
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View article: P11.20.A RETROSPECTIVE ANALYSIS OF LEPTOMENINGEAL METASTASES FROM SOLID TUMORS: A DIAGNOSTIC STRATIFICATION
P11.20.A RETROSPECTIVE ANALYSIS OF LEPTOMENINGEAL METASTASES FROM SOLID TUMORS: A DIAGNOSTIC STRATIFICATION Open
BACKGROUND Leptomeningeal metastasis (LM) is the spread of tumor cells to the arachnoid mater, pia mater or subarachnoid space by either hematogenous spread, direct extension from a contiguous intraparenchymal brain metastasis, or through …
View article: Excellence in oncology care (EIOC) consensus guidelines on the use of liquid biopsy and targeted therapy in early-stage and locally advanced non-small cell lung cancer (NSCLC) for the Middle East and Indian subcontinent
Excellence in oncology care (EIOC) consensus guidelines on the use of liquid biopsy and targeted therapy in early-stage and locally advanced non-small cell lung cancer (NSCLC) for the Middle East and Indian subcontinent Open
The Excellence in Oncology Care (EIOC) 2023 Congress, held in Dubai as a hybrid event, brought together oncologists from the Middle East and the Indian subcontinent. Two panels, comprising 33 experts, developed the first region-specific co…
View article: 70eP Decoding ambiguity of variants of uncertain significance (VUS) of non-small cell lung carcinoma (NSCLC) using a comprehensive NGS panel: Landmark study from an Indian cohort
70eP Decoding ambiguity of variants of uncertain significance (VUS) of non-small cell lung carcinoma (NSCLC) using a comprehensive NGS panel: Landmark study from an Indian cohort Open
View article: 36P Next-generation sequencing in liquid biopsy for advanced NSCLC: Indian tertiary cancer centre experience
36P Next-generation sequencing in liquid biopsy for advanced NSCLC: Indian tertiary cancer centre experience Open
View article: Implementation of circulating tumor DNA (ctDNA) testing in precision oncology: A four-year experience from a tertiary cancer center in India
Implementation of circulating tumor DNA (ctDNA) testing in precision oncology: A four-year experience from a tertiary cancer center in India Open
View article: 101P Homologous recombination deficiency testing in ovarian cancer: Challenges, insights, and clinical implications
101P Homologous recombination deficiency testing in ovarian cancer: Challenges, insights, and clinical implications Open
View article: International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors
International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors Open
View article: Clinical characteristics and first-line palliative treatment patterns in 3,414 patients with advanced lung cancer in India
Clinical characteristics and first-line palliative treatment patterns in 3,414 patients with advanced lung cancer in India Open
Lung cancer, particularly non-small-cell lung cancer (NSCLC), is a major global health issue. In India, the complexity of managing this disease is heightened by diverse demographics, varying healthcare access and evolving epidemiological t…
View article: Outcomes From a Contemporary Mono-Institutional Cohort of Histone-Mutant Diffuse Hemispheric Glioma: A Rare and Aggressive Pediatric-Type High-Grade Primary Brain Tumor
Outcomes From a Contemporary Mono-Institutional Cohort of Histone-Mutant Diffuse Hemispheric Glioma: A Rare and Aggressive Pediatric-Type High-Grade Primary Brain Tumor Open
H3 G34-mutant DHG is a rare, aggressive pediatric-type HGG with notable differences from adult counterparts. Recent biological insights implicating key signaling pathways provide unique opportunities to target therapeutic vulnerabilities i…
View article: Circulating tumor DNA (CTDNA) analysis for precision oncology: A tertiary oncology centre perspective in India
Circulating tumor DNA (CTDNA) analysis for precision oncology: A tertiary oncology centre perspective in India Open
View article: Performance of Low-Dose Immunotherapy and Standard-Dose Immunotherapy in Microsatellite Instability-High Metastatic Colorectal Cancer: Real-World Data (CLouD—High Study)
Performance of Low-Dose Immunotherapy and Standard-Dose Immunotherapy in Microsatellite Instability-High Metastatic Colorectal Cancer: Real-World Data (CLouD—High Study) Open
PURPOSE Standard-dose immune checkpoint inhibitors (SD-ICIs) are the standard of care as initial therapy in microsatellite instable-high (MSI-H) advanced/metastatic colorectal adenocarcinomas (mCRC), but there are preclinical data to sugge…
View article: Uniqueness of lung cancer in Southeast Asia
Uniqueness of lung cancer in Southeast Asia Open
View article: Docetaxel-oxaliplatin-capecitabine/5-fluorouracil (DOX/F) followed by docetaxel versus oxaliplatin-capecitabine/5-fluorouracil (CAPOX/FOLFOX) in HER2-negative advanced gastric cancers
Docetaxel-oxaliplatin-capecitabine/5-fluorouracil (DOX/F) followed by docetaxel versus oxaliplatin-capecitabine/5-fluorouracil (CAPOX/FOLFOX) in HER2-negative advanced gastric cancers Open
Background We evaluated whether the addition of docetaxel (D) to a combination comprising 5-fluorouracil/leucovorin (5-FU/LV) or capecitabine (C) plus oxaliplatin (O) (DOF/DOX) improved overall survival (OS) compared with 6 months of 5-flu…
View article: METB-06. PEDIATRIC BRAIN TUMOURS: A SINGLE INSTITUTIONAL EXPERIENCE OF NEXT GENERATION SEQUENCING-BASED TARGETED PANEL EVALUATION
METB-06. PEDIATRIC BRAIN TUMOURS: A SINGLE INSTITUTIONAL EXPERIENCE OF NEXT GENERATION SEQUENCING-BASED TARGETED PANEL EVALUATION Open
BACKGROUND Pediatric brain tumours (pBT) are molecularly diverse and with the advent of targeted-therapies it is important to decipher molecularly. METHODS Single institutional non-consecutive pBT (<18 years) cohort include – a. high-gr…
View article: MDB-55. LYMPHOID ENHANCER-BINDING FACTOR 1 (LEF1): AN IMMUNOHISTOCHEMICAL PREDICTIVE MARKER FOR WNT-ACTIVATED MEDULLOBLASTOMA
MDB-55. LYMPHOID ENHANCER-BINDING FACTOR 1 (LEF1): AN IMMUNOHISTOCHEMICAL PREDICTIVE MARKER FOR WNT-ACTIVATED MEDULLOBLASTOMA Open
AIM To evaluate lymphoid enhancer-binding factor 1 (LEF1) immunohistochemical expression in various molecular subtypes of medulloblastoma. MATERIALS AND METHODS Molecular subtyping of medulloblastomas was based on real-time PCR target 12 g…
View article: ETMR-16. PEDIATRIC SPINAL EMBRYONAL TUMORS; PATHOLOGICAL INSIGHTS INTO THIS RARE ENTITY
ETMR-16. PEDIATRIC SPINAL EMBRYONAL TUMORS; PATHOLOGICAL INSIGHTS INTO THIS RARE ENTITY Open
BACKGROUND Spinal cord is an extremely uncommon primary location for the CNS embryonal group of tumours. This study aims to collate the immunohistological spectrum of these rare spinal CNS embryonal tumours, diagnosed in the institute duri…
View article: Supplementary Table 8 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment
Supplementary Table 8 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment Open
Supplementary Table 8 shows the Genes included in qPCR validation.
View article: Supplementary Figure 4 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment
Supplementary Figure 4 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment Open
Supplementary Figure 4 shows the ClueGO Gene Ontology analysis for 85 genes de-regulated in both patient-specific analysis and replicate analysis for breast cancer RNA-Seq data.
View article: Supplementary Table 3 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment
Supplementary Table 3 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment Open
Supplementary Table 3 shows the Hallmarks, Canonical Pathways, and Gene Ontologies with FDR q-value <0.05 enriched in MSigDB for significantly de-regulated genes in each comparison (AvB, BvC and AvC) in individual patient time-series analy…
View article: Supplementary Figure 2 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment
Supplementary Figure 2 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment Open
Supplementary Figure 2 shows unsupervised clustering of Breast Cancer patients based on genome-wide expression counts.
View article: Supplementary Table 7 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment
Supplementary Table 7 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment Open
Supplementary Table 7 shows Genes de-regulated between various time-points during surgery in HNSCC Microarray data.
View article: Supplementary Table 2 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment
Supplementary Table 2 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment Open
Supplementary Table 2 shows the 4854 unique genes found to be de-regulated in any one comparison across all comparisons for AvB, BvC and AvC in for breast cancer individual patient specific RNA-Seq analysis.
View article: Supplementary Figure 1 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment
Supplementary Figure 1 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment Open
Supplementary Figure 1 shows the effect of various transformation methods on RNA-Seq data from breast cancer patients.
View article: Supplementary Table 7 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment
Supplementary Table 7 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment Open
Supplementary Table 7 shows Genes de-regulated between various time-points during surgery in HNSCC Microarray data.
View article: Supplementary Figure 2 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment
Supplementary Figure 2 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment Open
Supplementary Figure 2 shows unsupervised clustering of Breast Cancer patients based on genome-wide expression counts.
View article: Supplementary Table 5 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment
Supplementary Table 5 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment Open
Supplementary Table 5 shows the GO terms for 85 significantly de-regulated genes common to the individual patient time-series analysis and replicative analysis in Breast Cancer Patients.
View article: Supplementary Materials and Methods from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment
Supplementary Materials and Methods from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment Open
Supplementary Materials and Methods
View article: Data from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment
Data from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment Open
Surgery exposes tumor tissue to severe hypoxia and mechanical stress leading to rapid gene expression changes in the tumor and its microenvironment, which remain poorly characterized. We biopsied tumor and adjacent normal tissues from pati…
View article: Supplementary Table 1 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment
Supplementary Table 1 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment Open
Supplementary Table 1 shows the Breast cancer patient assay distribution and clinical info
View article: Supplementary Table 1 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment
Supplementary Table 1 from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment Open
Supplementary Table 1 shows the Breast cancer patient assay distribution and clinical info