Aniruddha Adhikari
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View article: Silver Nanoparticles Templated by the M13 Phage Exhibit High Antibacterial Activity against Gram-Negative Pathogens and a Reduced Rate of Bacterial Resistance In Vitro
Silver Nanoparticles Templated by the M13 Phage Exhibit High Antibacterial Activity against Gram-Negative Pathogens and a Reduced Rate of Bacterial Resistance In Vitro Open
Silver and silver nanoparticles (AgNPs) are well-known for their antibacterial properties. However, their low potency and the emergence of resistance are major barriers to the use of AgNPs in systemic therapy. Biological products can be us…
View article: Antibody‐Nanoparticle Conjugates in Therapy: Combining the Best of Two Worlds
Antibody‐Nanoparticle Conjugates in Therapy: Combining the Best of Two Worlds Open
Monoclonal antibodies (mAbs) and antibody fragments have revolutionized medicine as highly specific binding agents and inhibitors. At the same time, several types of nanomaterials, including liposomes, lipid nanoparticles (NPs), polymersom…
View article: Chitosan functionalized Mn3O4 nanoparticles counteracts ulcerative colitis in mice through modulation of cellular redox state
Chitosan functionalized Mn3O4 nanoparticles counteracts ulcerative colitis in mice through modulation of cellular redox state Open
Recent findings suggest a key role for reactive oxygen species (ROS) in the pathogenesis and progression of ulcerative colitis (UC). Several studies have also highlighted the efficacy of citrate functionalized Mn 3 O 4 nanoparticles as red…
View article: Non-invasive estimation of hemoglobin, bilirubin and oxygen saturation of neonates simultaneously using whole optical spectrum analysis at point of care
Non-invasive estimation of hemoglobin, bilirubin and oxygen saturation of neonates simultaneously using whole optical spectrum analysis at point of care Open
The study was aimed to evaluate the performance of a newly developed spectroscopy-based non-invasive and noncontact device (SAMIRA) for the simultaneous measurement of hemoglobin, bilirubin and oxygen saturation as an alternative to the in…
View article: A combined spectroscopic and molecular modeling Study on structure-function-dynamics under chemical modification: Alpha-chymotrypsin with formalin preservative
A combined spectroscopic and molecular modeling Study on structure-function-dynamics under chemical modification: Alpha-chymotrypsin with formalin preservative Open
Enzyme function can be altered via modification of its amino acid residues, side chains and large-scale domain modifications. Herein, we have addressed the role of residue modification in catalytic activity and molecular recognition of an …
View article: A nano erythropoiesis stimulating agent for the treatment of anemia and associated disorders
A nano erythropoiesis stimulating agent for the treatment of anemia and associated disorders Open
The usual treatment for anemia and especially for anemia of inflammation (also called anemia of chronic disease) is supportive care with the target of improving the lifestyle of the patients. There is no effective medication to date for pr…
View article: Oral drug delivery using a polymeric nanocarrier: chitosan nanoparticles in the delivery of rifampicin
Oral drug delivery using a polymeric nanocarrier: chitosan nanoparticles in the delivery of rifampicin Open
Oral delivery of rifampicin through chitosan nanoparticles.
View article: Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice
Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice Open
View article: Essential Loop Dynamics Modulates Catalytic Activity in α-Chymotrypsin
Essential Loop Dynamics Modulates Catalytic Activity in α-Chymotrypsin Open
Conformational dynamics of macromolecules including enzymes are essential for their function. The present work reports the role of essential dynamics in alpha-chymotrypsin (CHT) which correlates with its catalytic activity. Detailed optica…
View article: A Combined Spectroscopic and Molecular Modeling Study on Structure-Function-Dynamics under Chemical Modification: Alpha-Chymotrypsin with Formalin Preservative
A Combined Spectroscopic and Molecular Modeling Study on Structure-Function-Dynamics under Chemical Modification: Alpha-Chymotrypsin with Formalin Preservative Open
Enzyme conformations can be altered via modification of its amino acid residues, side chains and large-scale domain modifications, which are closely linked to its function. Herein, we have addressed the role of residue modification in cata…
View article: Synthesis and characterization of a nano-formulation for long lasting sterilization effect
Synthesis and characterization of a nano-formulation for long lasting sterilization effect Open
View article: Redox Buffering Capacity of Nanomaterials as an Index of ROS-based Therapeutics and Toxicity: A Preclinical Animal Study
Redox Buffering Capacity of Nanomaterials as an Index of ROS-based Therapeutics and Toxicity: A Preclinical Animal Study Open
Precise control of intracellular redox status, i.e., maintenance of physiological level of reactive oxygen species (ROS) for mediating normal cellular functions (oxidative eustress) while evading the excess ROS stress (distress) is central…
View article: Redox Nanomedicine Cures Chronic Kidney Disease (CKD) by Mitochondrial Reconditioning
Redox Nanomedicine Cures Chronic Kidney Disease (CKD) by Mitochondrial Reconditioning Open
Targeting reactive oxygen species (ROS) while maintaining cellular redox signaling is crucial in the development of redox medicine for the therapeutic benefit as the origin of several prevailing diseases including chronic kidney disease (C…
View article: Development of Tribo-Electroceutical Fabrics for Potential Application in Self-sanitizing Personal Protective Equipment (PPE)
Development of Tribo-Electroceutical Fabrics for Potential Application in Self-sanitizing Personal Protective Equipment (PPE) Open
Attachment of microbial bodies including coronavirus on the surface of personal protective equipment (PPE) is found to be potential threat of spreading infection. Here, we report the development of a novel tribo-electroceutical fabric (TEC…
View article: Nanoceutical Fabric Prevents COVID-19 Spread through Expelled Respiratory Droplets: A Combined Computational, Spectroscopic and Anti-microbial Study
Nanoceutical Fabric Prevents COVID-19 Spread through Expelled Respiratory Droplets: A Combined Computational, Spectroscopic and Anti-microbial Study Open
Centers for Disease Control and Prevention (CDC) warns the use of one-way valves or vents in free masks for potential threat of spreading COVID-19 through expelled respiratory droplets. Here, we have developed a nanoceutical cotton fabric …
View article: An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care
An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care Open
View article: A Nanoceutical Agent for Chemoprevention of Bilirubin Encephalopathy
A Nanoceutical Agent for Chemoprevention of Bilirubin Encephalopathy Open
Background Targeted degradation of bilirubin in vivo may enable safer and more effective approach to manage incipient bilirubin encephalopathy consequent to severe neonatal hyperbilirubinemia (SNH). This report builds on the use of a spine…
View article: Spectroscopic Studies on the Biomolecular Recognition of Toluidine Blue: Key Information Towards Development of a Non-Contact, Non-Invasive Device for Oral Cancer Detection
Spectroscopic Studies on the Biomolecular Recognition of Toluidine Blue: Key Information Towards Development of a Non-Contact, Non-Invasive Device for Oral Cancer Detection Open
Molecular interaction of aromatic dyes with biological macromolecules are important for the development of minimally invasive disease diagnostic biotechnologies. In the present work, we have used Toluidine Blue (TB) as a model dye, which i…
View article: Incorporation of a Biocompatible Nanozyme in Cellular Antioxidant Enzyme Cascade Reverses Huntington’s Like Disorder in Preclinical Model
Incorporation of a Biocompatible Nanozyme in Cellular Antioxidant Enzyme Cascade Reverses Huntington’s Like Disorder in Preclinical Model Open
The potentiality of nano-enzymes in therapeutic use has directed contemporary research to develop a substitute for natural enzymes, which are suffering from several disadvantages including low stability, high cost, and difficulty in storag…
View article: Large scale validation of a new non-invasive and non-contact bilirubinometer in neonates with risk factors
Large scale validation of a new non-invasive and non-contact bilirubinometer in neonates with risk factors Open
View article: Correction: Manganese neurotoxicity: nano-oxide compensates for ion-damage in mammals
Correction: Manganese neurotoxicity: nano-oxide compensates for ion-damage in mammals Open
Correction for ‘Manganese neurotoxicity: nano-oxide compensates for ion-damage in mammals’ by Aniruddha Adhikari et al., Biomater. Sci., 2019, 7, 4491–4502, DOI: 10.1039/C9BM01039D.
View article: Novel one pot synthesis and spectroscopic characterization of a folate-Mn<sub>3</sub>O<sub>4</sub> nanohybrid for potential photodynamic therapeutic application
Novel one pot synthesis and spectroscopic characterization of a folate-Mn<sub>3</sub>O<sub>4</sub> nanohybrid for potential photodynamic therapeutic application Open
Folate capped Mn3O4 nanoparticles can be used in PDT for specifically destroying folate receptor-overexpressing cancer cells through photo induced free radical damage.
View article: Role of Nanomedicine in Redox Mediated Healing at Molecular Level
Role of Nanomedicine in Redox Mediated Healing at Molecular Level Open
Nanomedicine, the offspring born from the marriage of nanotechnology and medicine, has already brought momentous advances in the fight against a plethora of unmet diseases from cardiovascular and neurodegenerative to diabetes and cancer. H…
View article: Spectroscopic Studies on Dual Role of Natural Flavonoids in Detoxification of Lead Poisoning: Bench-to-Bedside Preclinical Trial
Spectroscopic Studies on Dual Role of Natural Flavonoids in Detoxification of Lead Poisoning: Bench-to-Bedside Preclinical Trial Open
Ubiquitousness in the target organs and associated oxidative stress are the most common manifestations of heavy-metal poisoning in living bodies. While chelation of toxic heavy metals is important as therapeutic strategy, scavenging of inc…
View article: Development and validation of a noncontact spectroscopic device for hemoglobin estimation at point-of-care
Development and validation of a noncontact spectroscopic device for hemoglobin estimation at point-of-care Open
Anemia severely and adversely affects human health and socioeconomic development. Measuring hemoglobin with the minimal involvement of human and financial resources has always been challenging. We describe a translational spectroscopic tec…
View article: Citrate Functionalized Mn<sub>3</sub>O<sub>4</sub>in Nanotherapy of Hepatic Fibrosis by Oral Administration
Citrate Functionalized Mn<sub>3</sub>O<sub>4</sub>in Nanotherapy of Hepatic Fibrosis by Oral Administration Open
These findings may pave the way for practical clinical use of the NPs as safe medication of chronic liver diseases associated with fibrosis and cirrhosis in human subjects.
View article: Development and optimization of a noncontact optical device for online monitoring of jaundice in human subjects
Development and optimization of a noncontact optical device for online monitoring of jaundice in human subjects Open
Jaundice is one of the notable markers of liver malfunction in our body, revealing a significant rise in the concentration of an endogenous yellow pigment bilirubin. We have described a method for measuring the optical spectrum of our conj…