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View article: Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output
Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output Open
Striatal spiny-projection neurons (SPNs) integrate glutamatergic inputs from the motor cortex and thalamus with neuromodulatory signals to regulate motor output. In vivo Ca2+ imaging has demonstrated that spatially overlapping ensembles of…
View article: Exaggerated NMDA Receptor–Primed Metaplasticity via SK Channel Dysregulation in <i>Fmr1</i> Knockout Mice
Exaggerated NMDA Receptor–Primed Metaplasticity via SK Channel Dysregulation in <i>Fmr1</i> Knockout Mice Open
Fragile X syndrome (FXS), the most common monogenic neurodevelopmental disorder associated with autism and intellectual disability, results from the loss of expression of the FMR1 gene. Synaptic and circuit-level abnormalities are well doc…
View article: Operant House: A Versatile Open-Source Platform for Automated Operant Conditioning Testing of Mice in Home Cages
Operant House: A Versatile Open-Source Platform for Automated Operant Conditioning Testing of Mice in Home Cages Open
Operant conditioning is a valuable method for studying cognitive functions, yet its adoption is limited by low throughput, labor intensity, and high costs. Here, we developed “Operant House,” a low-cost, programmable device featuring a tou…
View article: Subregional activity in the dentate gyrus is amplified during elevated cognitive demands
Subregional activity in the dentate gyrus is amplified during elevated cognitive demands Open
Neural activity in the dentate gyrus (DG) is required for the detection and discrimination of novelty, context and patterns, amongst other cognitive processes. Prior work has demonstrated that there are differences in the activation of gra…
View article: Levetiracetam prevents Aβ42 production through SV2a-dependent modulation of App processing in Alzheimer’s disease models
Levetiracetam prevents Aβ42 production through SV2a-dependent modulation of App processing in Alzheimer’s disease models Open
In Alzheimer’s disease (AD), amyloid-beta (Aβ) peptides are produced by proteolytic cleavage of the amyloid precursor protein (APP), which can occur during synaptic vesicle (SV) cycling at presynapses. Precisely how amyloidogenic APP proce…
View article: Human Neuron and Mouse Models Reveal Synaptic Imbalance in Kabuki Syndrome
Human Neuron and Mouse Models Reveal Synaptic Imbalance in Kabuki Syndrome Open
Intellectual disability, affecting 2-3% of the general population, often co-occurs with neurodevelopmental disorders and is frequently caused by mutations that impair synaptic function. Kabuki syndrome (KS), a rare multisystem disorder ass…
View article: Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses
Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses Open
Long-term synaptic plasticity at glutamatergic synapses on striatal spiny projection neurons (SPNs) is central to learning goal-directed behaviors and habits. Our studies reveal that SPNs manifest a heterosynaptic, nitric oxide (NO)-depend…
View article: Reviewer #1 (Public Review): Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output
Reviewer #1 (Public Review): Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output Open
Striatal spiny-projection neurons (SPNs) integrate glutamatergic inputs from the motor cortex and thalamus with neuromodulatory signals to regulate motor output. In vivo Ca2+ imaging has demonstrated that ensembles of direct and indirect p…
View article: Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output
Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output Open
Striatal spiny-projection neurons (SPNs) integrate glutamatergic inputs from the motor cortex and thalamus with neuromodulatory signals to regulate motor output. In vivo Ca2+ imaging has demonstrated that spatially overlapping ensembles of…
View article: Reviewer #2 (Public Review): Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output
Reviewer #2 (Public Review): Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output Open
Striatal spiny-projection neurons (SPNs) integrate glutamatergic inputs from the motor cortex and thalamus with neuromodulatory signals to regulate motor output. In vivo Ca2+ imaging has demonstrated that ensembles of direct and indirect p…
View article: Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output
Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output Open
Striatal spiny-projection neurons (SPNs) integrate glutamatergic inputs from the motor cortex and thalamus with neuromodulatory signals to regulate motor output. In vivo Ca2+ imaging has demonstrated that ensembles of direct and indirect p…
View article: Reviewer #3 (Public Review): Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output
Reviewer #3 (Public Review): Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output Open
Striatal spiny-projection neurons (SPNs) integrate glutamatergic inputs from the motor cortex and thalamus with neuromodulatory signals to regulate motor output. In vivo Ca2+ imaging has demonstrated that ensembles of direct and indirect p…
View article: Ca<sup>2+</sup>-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses
Ca<sup>2+</sup>-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses Open
Summary Long-term synaptic plasticity at glutamatergic synapses on striatal spiny projection neurons (SPNs) is central to learning goal-directed behaviors and habits. Although considerable attention has been paid to the mechanisms underlyi…
View article: Notch receptor-ligand binding facilitates extracellular vesicle-mediated neuron-to-neuron communication
Notch receptor-ligand binding facilitates extracellular vesicle-mediated neuron-to-neuron communication Open
Extracellular vesicles (EVs) facilitate intercellular communication by transferring cargo between cells in a variety of tissues. However, how EVs achieve cell-type-specific intercellular communication is still largely unknown. We found tha…
View article: Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output
Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output Open
Striatal spiny-projection neurons (SPNs) integrate glutamatergic inputs from the motor cortex and thalamus with neuromodulatory signals to regulate motor output. In vivo Ca 2+ imaging has demonstrated that spatially overlapping ensembles o…
View article: A Pathogenic Missense Mutation in Kainate Receptors Elevates Dendritic Excitability and Synaptic Integration through Dysregulation of SK Channels
A Pathogenic Missense Mutation in Kainate Receptors Elevates Dendritic Excitability and Synaptic Integration through Dysregulation of SK Channels Open
Numerous rare variants that cause neurodevelopmental disorders (NDDs) occur within genes encoding synaptic proteins, including ionotropic glutamate receptors. However, in many cases, it remains unclear how damaging missense variants affect…
View article: Editorial: Neural markers of sensory processing in development
Editorial: Neural markers of sensory processing in development Open
EDITORIAL article Front. Integr. Neurosci., 21 July 2023 Volume 17 - 2023 | https://doi.org/10.3389/fnint.2023.1256437
View article: A pathogenic missense mutation in kainate receptors elevates dendritic excitability and synaptic integration through dysregulation of SK channels
A pathogenic missense mutation in kainate receptors elevates dendritic excitability and synaptic integration through dysregulation of SK channels Open
Numerous rare de novo variants that cause neurodevelopmental disorders (NDDs) occur within genes encoding synaptic proteins, including ionotropic glutamate receptors (iGluRs). However, in many cases it remains unclear how damaging missense…
View article: Protocol to map multi-transmitter neurons in the mouse brain using intersectional strategy
Protocol to map multi-transmitter neurons in the mouse brain using intersectional strategy Open
Although it is now known that certain neurons can produce, store, and release multiple neurotransmitters, their locations, abundance, and functions remain elusive. We developed intersectional genetic strategies to identify multi-transmitte…
View article: Modulating D1 rather than D2 receptor-expressing spiny-projection neurons corresponds to optimal antipsychotic effect
Modulating D1 rather than D2 receptor-expressing spiny-projection neurons corresponds to optimal antipsychotic effect Open
Overactive dopamine transmission in psychosis is predicted to unbalance striatal output via D1- and D2-dopamine receptor-expressing spiny-projection neurons (SPNs). Antipsychotic drugs are thought to re-balance this output by blocking D2-r…
View article: Gabra2 is a genetic modifier of Dravet syndrome in mice
Gabra2 is a genetic modifier of Dravet syndrome in mice Open
Pathogenic variants in epilepsy genes result in a spectrum of clinical severity. One source of phenotypic heterogeneity is modifier genes that affect expressivity of a primary pathogenic variant. Mouse epilepsy models also display varying …