Anita Nitchingham
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View article: Long-acting intranasal insulin for the treatment of delirium—a randomised clinical trial
Long-acting intranasal insulin for the treatment of delirium—a randomised clinical trial Open
Background Delirium affects up to 25% of hospitalised older patients; however, there are no effective pharmacological treatments. Accumulating evidence of brain insulin resistance and altered cerebral glucose metabolism during delirium pre…
View article: Persistent delirium in older hospital patients: an updated systematic review and meta-analysis
Persistent delirium in older hospital patients: an updated systematic review and meta-analysis Open
Introduction Delirium is associated with future dementia progression. Yet whether this occurs subclinically over months and years, or persistent delirium merges into worsened dementia is not understood. Our objective was to estimate the pr…
View article: Regional cerebral hypometabolism on 18F‐FDG PET/CT scan in delirium is independent of acute illness and dementia
Regional cerebral hypometabolism on 18F‐FDG PET/CT scan in delirium is independent of acute illness and dementia Open
Introduction Delirium is associated with new onset dementia and accelerated cognitive decline; however, its pathophysiology remains unknown. Cerebral glucose metabolism previously seen in delirium may have been attributable to acute illnes…
View article: Persistent delirium in older hospital patients: an updated systematic review and meta-analysis
Persistent delirium in older hospital patients: an updated systematic review and meta-analysis Open
Introduction Persistent delirium is recognised as a substantial problem, but there are few insights into which patient groups might be particularly affected. Delirium is associated with future dementia progression. Yet whether this occurs …
View article: Intranasal insulin for treatment of delirium in older hospitalised patients: study protocol for a randomised controlled trial
Intranasal insulin for treatment of delirium in older hospitalised patients: study protocol for a randomised controlled trial Open
Introduction Delirium is one of the most common conditions diagnosed in hospitalised older people and is associated with numerous adverse outcomes, yet there are no proven pharmacological treatments. Recent research has identified cerebral…
View article: Current Challenges in the Recognition and Management of Delirium Superimposed on Dementia
Current Challenges in the Recognition and Management of Delirium Superimposed on Dementia Open
Delirium occurring in a patient with preexisting dementia is referred to as delirium superimposed on dementia (DSD). DSD commonly occurs in older hospitalized patients and is associated with worse outcomes, including higher rates of mortal…