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Vasopressin Initiation Timing and In-Hospital Mortality in Septic Shock: An Observational Study of Large Public Databases Open

Gretchen L. Sacha, Abhijit Duggal, Anita Reddy, Lu Wang, Seth R. Bauer · 2025

IMPORTANCE: Vasopressin is used in one-third of patients with septic shock to augment hemodynamics and reduce overall catecholamine exposure. However, the optimal clinical context in which to initiate vasopressin is unknown. OBJECTIVES: To…

Revisiting insulin-stimulated hydrogen peroxide dynamics reveals a cytosolic reductive shift in skeletal muscle Open

Carlos Henríquez‐Olguín, Samantha Gallero, Anita Reddy, Kaspar W. Persson, Farina Schlabs , et al. · 2025

Peripheral Administration of Norepinephrine Open

Jason Yerke, Eduardo Mireles‐Cabodevila, Alyssa Y. Chen, Stephanie Bass, Anita Reddy , et al. · 2023

Table S1 from First-in-Human Phase I Study of ABBV-838, an Antibody–Drug Conjugate Targeting SLAMF7/CS1 in Patients with Relapsed and Refractory Multiple Myeloma Open

Ravi Vij, Rajneesh Nath, Daniel Afar, María‐Victoria Mateos, Jesús G. Berdeja , et al. · 2023

Overall summary of treatment-emergent adverse events

Figure S1 from First-in-Human Phase I Study of ABBV-838, an Antibody–Drug Conjugate Targeting SLAMF7/CS1 in Patients with Relapsed and Refractory Multiple Myeloma Open

Ravi Vij, Rajneesh Nath, Daniel Afar, María‐Victoria Mateos, Jesús G. Berdeja , et al. · 2023

Study design schematic. N, number of patients in each dose group; PK/PD, pharmacokinetics/pharmacodynamics.

Figure S1 from First-in-Human Phase I Study of ABBV-838, an Antibody–Drug Conjugate Targeting SLAMF7/CS1 in Patients with Relapsed and Refractory Multiple Myeloma Open

Ravi Vij, Rajneesh Nath, Daniel Afar, María‐Victoria Mateos, Jesús G. Berdeja , et al. · 2023

Study design schematic. N, number of patients in each dose group; PK/PD, pharmacokinetics/pharmacodynamics.

Data from First-in-Human Phase I Study of ABBV-838, an Antibody–Drug Conjugate Targeting SLAMF7/CS1 in Patients with Relapsed and Refractory Multiple Myeloma Open

Ravi Vij, Rajneesh Nath, Daniel Afar, María‐Victoria Mateos, Jesús G. Berdeja , et al. · 2023

Purpose:ABBV-838 is an antibody–drug conjugate targeting a unique epitope of CD2 subset 1, a cell-surface glycoprotein expressed on multiple myeloma cells. This phase I/Ib first-in-human, dose-escalation study (trial registration ID: NCT02…

Data from First-in-Human Phase I Study of ABBV-838, an Antibody–Drug Conjugate Targeting SLAMF7/CS1 in Patients with Relapsed and Refractory Multiple Myeloma Open

Ravi Vij, Rajneesh Nath, Daniel Afar, María‐Victoria Mateos, Jesús G. Berdeja , et al. · 2023

Purpose:ABBV-838 is an antibody–drug conjugate targeting a unique epitope of CD2 subset 1, a cell-surface glycoprotein expressed on multiple myeloma cells. This phase I/Ib first-in-human, dose-escalation study (trial registration ID: NCT02…

Table S1 from First-in-Human Phase I Study of ABBV-838, an Antibody–Drug Conjugate Targeting SLAMF7/CS1 in Patients with Relapsed and Refractory Multiple Myeloma Open

Ravi Vij, Rajneesh Nath, Daniel Afar, María‐Victoria Mateos, Jesús G. Berdeja , et al. · 2023

Overall summary of treatment-emergent adverse events

Lactate regulates cell cycle by remodelling the anaphase promoting complex Open

Weihai Liu, Yun Wang, Luiz H. M. Bozi, Patrick D. Fischer, Mark P. Jedrychowski , et al. · 2023

Monocarboxylate transporters facilitate succinate uptake into brown adipocytes Open

Anita Reddy, Sally Winther, Nhien Tran, Haopeng Xiao, Josefine Jakob , et al. · 2023

Uptake of circulating succinate by brown adipose tissue (BAT) and beige fat elevates whole body energy expenditure, counteracts obesity, and antagonizes systemic tissue inflammation in mice. The plasma membrane transporters that facilitate…

Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues Open

Melanie J. Mittenbühler, Mark P. Jedrychowski, Jonathan G. Van Vranken, Hans‐Georg Sprenger, Sarah E. Wilensky , et al. · 2023

Architecture of the outbred brown fat proteome defines regulators of metabolic physiology Open

Haopeng Xiao, Luiz H. M. Bozi, Yizhi Sun, Christopher L. Riley, Vivek M. Philip , et al. · 2022

Association of Arterial pH With Hemodynamic Response to Vasopressin in Patients With Septic Shock: An Observational Cohort Study Open

Seth R. Bauer, Gretchen L. Sacha, Matthew Siuba, Simon W. Lam, Anita Reddy , et al. · 2022

OBJECTIVES: Vasopressin is reported to retain vasoconstrictive activity in the setting of acidemia, but preclinical models are inconsistent and studies have not evaluated the clinical effectiveness of vasopressin based on arterial pH. This…

Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets Open

Accalia Fu, Lara van Rooyen, Lindsay Evans, Nina Armstrong, Daina Avizonis , et al. · 2021

UCP1 governs liver extracellular succinate and inflammatory pathogenesis Open

Evanna L. Mills, Cathal Harmon, Mark P. Jedrychowski, Haopeng Xiao, Ryan Garrity , et al. · 2021

Reinfection Rates Among Patients Who Previously Tested Positive for Coronavirus Disease 2019: A Retrospective Cohort Study Open

Megan Sheehan, Anita Reddy, Michael B. Rothberg · 2021

Background Protection afforded from prior disease among patients with coronavirus disease 2019 (COVID-19) infection is unknown. If infection provides substantial long-lasting immunity, it may be appropriate to reconsider vaccination distri…

Reinfection Rates among Patients who Previously Tested Positive for COVID-19: a Retrospective Cohort Study Open

Megan Sheehan, Anita Reddy, Michael B. Rothberg · 2021

Objectives To evaluate reinfection rates and protective effectiveness of prior disease among patients with coronavirus disease 2019 (COVID-19) infection in the United States. Design Retrospective cohort study Setting One multi-hospital hea…

Home testing for COVID-19: Benefits and limitations Open

Gary W. Procop, Kamran Kadkhoda, Daniel D. Rhoads, Steven G. Gordon, Anita Reddy · 2021

The home test kits for detecting SARS-CoV-2 infection with Food and Drug Administration emergency use authorization primarily use either isothermal nucleic acid amplification or antigen detection, and each test has advantages and limitatio…

Response Open

Seth R. Bauer, Xiaozhen Han, Xiaofeng Wang, Anita Reddy · 2021

Safety of bedside placement of tunneled dialysis catheter in COVID-19 patients Open

Tarik Hanane, James Lane, Eduardo Mireles‐Cabodevila, Anita Reddy, Jonathan J. Taliercio , et al. · 2020

COVID-19 patients admitted to the ICU have high incidence of AKI requiring prolonged renal replacement therapy and often necessitate the placement of a tunneled dialysis catheter (TDC). We describe our experience with two cases of COVID-19…

Hemodynamic Response to Vasopressin Dosage of 0.03 Units/Min vs. 0.04 Units/Min in Patients With Septic Shock Open

Seth R. Bauer, Gretchen L. Sacha, Simon W. Lam, Lu Wang, Anita Reddy , et al. · 2020

Background: Arginine vasopressin (AVP) is suggested as an adjunct to norepinephrine in patients with septic shock. Guidelines recommend an AVP dosage up to 0.03 units/min, but 0.04 units/min is commonly used in practice based on initial st…

pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise Open

Anita Reddy, Luiz H. M. Bozi, Omar Yaghi, Evanna L. Mills, Haopeng Xiao , et al. · 2020

Interhospital transport of patients with COVID-19: Cleveland Clinic approach Open

Abigail Brown, Fredric M. Hustey, Anita Reddy · 2020

Hospital-to-hospital transportation of patients in the COVID-19 era presents unique challenges to ensuring the safety of both patients and health care providers. Crucial factors to address include having adequate supplies of protective equ…

Operationalizing COVID-19 testing: Who, what, when, where, why, and how Open

Anita Reddy, Thomas G. Fraser, Purva Grover, Allison L. Weathers, Michael Cruise , et al. · 2020

The authors review the rationale behind and approaches to testing for COVID-19, the quality of currently available tests, the role of data analytics in strategizing testing, and using the electronic medical record and other programs design…

Association Between Compliance With the Sepsis Quality Measure (SEP-1) and Hospital Readmission Open

Seth R. Bauer, Xiaozhen Han, Xiaofeng Wang, Heather Blonsky, Anita Reddy · 2020

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging Open

Haopeng Xiao, Mark P. Jedrychowski, Devin K. Schweppe, Edward L. Huttlin, Qing Yu , et al. · 2020

Bispectral Index for Titrating Sedation in ARDS Patients During Neuromuscular Blockade Open

Stephanie Bass, Mark L Vance, Anita Reddy, Seth R. Bauer, Erin Roach , et al. · 2019

Titration based on bispectral index did not result in a significant difference in sedation or analgesia exposure, or clinical outcomes, from that achieved with traditional sedation monitoring in patients with ARDS who were receiving a neur…

Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice Open

Hye‐Youn Cho, Laura Miller‐DeGraff, Terry L Blankenship-Paris, Xuting Wang, Douglas A. Bell , et al. · 2018

Joblessness and Lost Earnings after Acute Respiratory Distress Syndrome in a 1-Year National Multicenter Study Open

Biren B. Kamdar, Minxuan Huang, Victor D. Dinglas, Elizabeth Colantuoni, Till M. von Wachter , et al. · 2017

At 12 months after ARDS, nearly one-half of previously employed survivors were jobless. Post-ARDS joblessness is associated with readily identifiable patient and hospital variables and accompanied by substantial lost earnings and a shift t…

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