Anja Dillenseger
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View article: From implementation to discontinuation: multi-year experience with the multiple sclerosis performance test as a digital monitoring tool
From implementation to discontinuation: multi-year experience with the multiple sclerosis performance test as a digital monitoring tool Open
Introduction Digital tools such as the self-administered Multiple Sclerosis Performance Test (MSPT) support structured monitoring of multiple sclerosis (MS) through standardized assessments of motor, visual, and cognitive functions. Despit…
View article: A roadmap for safe, regulation-compliant Living Labs for AI and digital health development
A roadmap for safe, regulation-compliant Living Labs for AI and digital health development Open
Safe and agile experimentation spaces are essential for developing AI-enabled medical devices and digital health innovations. “Living Labs” offer a collaborative environment for testing technologies in near-real-world settings, capturing u…
View article: Cost–consequence analysis of early vs. delayed natalizumab use in highly active relapsing–remitting multiple sclerosis: a simulation study
Cost–consequence analysis of early vs. delayed natalizumab use in highly active relapsing–remitting multiple sclerosis: a simulation study Open
Background Natalizumab (NAT) is an established disease-modifying therapy (DMT) for highly active multiple sclerosis (MS). However, its use involves complex decision-making, often leading to initial use of lower efficacy therapies. Recently…
View article: Detecting fatigue in multiple sclerosis through automatic speech analysis
Detecting fatigue in multiple sclerosis through automatic speech analysis Open
Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by central nervous system demyelination and axonal degeneration. Fatigue affects a major portion of MS patients, significantly impairing their daily activities an…
View article: Insights from Real-World Practice: The Dynamics of SARS-CoV-2 Infections and Vaccinations in a Large German Multiple Sclerosis Cohort
Insights from Real-World Practice: The Dynamics of SARS-CoV-2 Infections and Vaccinations in a Large German Multiple Sclerosis Cohort Open
The SARS-CoV-2 pandemic profoundly impacted people with multiple sclerosis (pwMS). Disease-related aspects and demographic factors may influence vaccination rates, infection susceptibility, and severity. Despite prior research, comprehensi…
View article: Claims-based algorithm to estimate the Expanded Disability Status Scale for multiple sclerosis in a German health insurance fund: a validation study using patient medical records
Claims-based algorithm to estimate the Expanded Disability Status Scale for multiple sclerosis in a German health insurance fund: a validation study using patient medical records Open
Background The Expanded Disability Status Scale (EDSS) quantifies disability and measures disease progression in multiple sclerosis (MS), however is not available in administrative claims databases. Objectives To develop a claims-based alg…
View article: Differential effects of selective versus unselective sphingosine 1-phosphate receptor modulators on T- and B-cell response to SARS-CoV-2 vaccination
Differential effects of selective versus unselective sphingosine 1-phosphate receptor modulators on T- and B-cell response to SARS-CoV-2 vaccination Open
Background: Sphingosine 1-phosphat receptor modulators (S1PRMs) have been linked to attenuated immune response to SARS-CoV-2 vaccines. Objective: To characterize differences in the immune response to SARS-CoV-2 vaccines in patients on sele…
View article: Long-Term Immune Response Profiles to SARS-CoV-2 Vaccination and Infection in People with Multiple Sclerosis on Anti-CD20 Therapy
Long-Term Immune Response Profiles to SARS-CoV-2 Vaccination and Infection in People with Multiple Sclerosis on Anti-CD20 Therapy Open
Our objective was to analyze longitudinal cellular and humoral immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in people with multiple sclerosis (pwMS) on B-cell depleting treatment (BCDT) compa…
View article: Data Resource Profile: The Multiple Sclerosis Documentation System 3D and AOK PLUS Linked Database (MSDS-AOK PLUS)
Data Resource Profile: The Multiple Sclerosis Documentation System 3D and AOK PLUS Linked Database (MSDS-AOK PLUS) Open
Real-world evidence in multiple sclerosis (MS) is limited by the availability of data elements in individual real-world datasets. We introduce a novel, growing database which links administrative claims and medical records from an MS patie…
View article: RWD58 Coding of Multiple Sclerosis Subtypes in German Administrative Claims Data: A Validation Study Using the MSDS-AOK PLUS Linked Database
RWD58 Coding of Multiple Sclerosis Subtypes in German Administrative Claims Data: A Validation Study Using the MSDS-AOK PLUS Linked Database Open
View article: Digital Biomarkers in Multiple Sclerosis
Digital Biomarkers in Multiple Sclerosis Open
For incurable diseases, such as multiple sclerosis (MS), the prevention of progression and the preservation of quality of life play a crucial role over the entire therapy period. In MS, patients tend to become ill at a younger age and are …
View article: Profiles of eHealth Adoption in Persons with Multiple Sclerosis and Their Caregivers
Profiles of eHealth Adoption in Persons with Multiple Sclerosis and Their Caregivers Open
(1) Background: Persons with multiple sclerosis (pwMS) are often characterized as ideal adopters of new digital healthcare trends, but it is worth thinking about whether and which pwMS will be targeted and served by a particular eHealth se…
View article: Digital Twins for Multiple Sclerosis
Digital Twins for Multiple Sclerosis Open
An individualized innovative disease management is of great importance for people with multiple sclerosis (pwMS) to cope with the complexity of this chronic, multidimensional disease. However, an individual state of the art strategy, with …
View article: On the Reliability of Examining Dual-Tasking Abilities Using a Novel E-Health Device—A Proof of Concept Study in Multiple Sclerosis
On the Reliability of Examining Dual-Tasking Abilities Using a Novel E-Health Device—A Proof of Concept Study in Multiple Sclerosis Open
The assessment of neuropsychological functions and especially dual-tasking abilities is considered to be increasingly relevant in the assessment of neurological disease, and Multiple Sclerosis (MS) in particular. However, the assessment of…
View article: On the reliability of examining dual-tasking abilities using a novel e-Health device – a proof of concept study in Multiple Sclerosis
On the reliability of examining dual-tasking abilities using a novel e-Health device – a proof of concept study in Multiple Sclerosis Open
The assessment of neuropsychological functions and especially dual-tasking abilities is considered to be increasingly relevant in the assessment of neurological disease and Multiple Sclerosis (MS) in particular. Yet, the assessment of dual…