Anja Kopp
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View article: Pyroptosis inhibiting nanobodies block Gasdermin D pore formation
Pyroptosis inhibiting nanobodies block Gasdermin D pore formation Open
Human Gasdermin D (GSDMD) is a key mediator of pyroptosis, a pro-inflammatory form of cell death occurring downstream of inflammasome activation as part of the innate immune defence. Upon cleavage by inflammatory caspases in the cytosol, t…
View article: Antagonistic nanobodies reveal mechanism of GSDMD pore formation and unexpected therapeutic potential
Antagonistic nanobodies reveal mechanism of GSDMD pore formation and unexpected therapeutic potential Open
Activation of various inflammasomes converges on the cleavage of gasdermin D (GSDMD) by pro-inflammatory caspases, followed by oligomerization of the N-terminal domain (GSDMD NT ) and the assembly of pores penetrating target membranes. Yet…
View article: Pyroptosis inhibiting nanobodies block Gasdermin D pore formation
Pyroptosis inhibiting nanobodies block Gasdermin D pore formation Open
Gasdermin D (GSDMD) is a key mediator of pyroptosis, a pro-inflammatory form of cell death occurring downstream of inflammasome activation as part of the innate immune defence. Upon cleavage by inflammatory caspases, the N-terminal domain …
View article: Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation
Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation Open
Inflammasomes sense intrinsic and extrinsic danger signals to trigger inflammatory responses and pyroptotic cell death. Homotypic pyrin domain (PYD) interactions of inflammasome forming nucleotide-binding oligomerization domain (NOD)–like …
View article: Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation
Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation Open
SUMMARY Inflammasomes sense intrinsic and extrinsic danger signals to trigger inflammatory responses and pyroptotic cell death. Homotypic pyrin domain (PYD) interactions of inflammasome forming Nod-like receptors with the adaptor protein A…
View article: Single-Point Mutations within the Coxsackie B Virus Receptor-Binding Site Promote Resistance against Soluble Virus Receptor Traps
Single-Point Mutations within the Coxsackie B Virus Receptor-Binding Site Promote Resistance against Soluble Virus Receptor Traps Open
The emergence of resistant viruses is one of the most frequent obstacles preventing successful therapy of viral infections, representing a significant threat to human health. We investigated the emergence of resistant viruses during treatm…
View article: Absolute Protein Amounts and Relative Abundance of Volume-regulated Anion Channel (VRAC) LRRC8 Subunits in Cells and Tissues Revealed by Quantitative Immunoblotting
Absolute Protein Amounts and Relative Abundance of Volume-regulated Anion Channel (VRAC) LRRC8 Subunits in Cells and Tissues Revealed by Quantitative Immunoblotting Open
The volume-regulated anion channel (VRAC) plays an important role in osmotic cell volume regulation. In addition, it is involved in various physiological processes such as insulin secretion, glia-neuron communication and purinergic signali…