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View article: Blind But Alive – Congenital Loss of <i>atoh7</i> Disrupts the Visual System of Adult Zebrafish
Blind But Alive – Congenital Loss of <i>atoh7</i> Disrupts the Visual System of Adult Zebrafish Open
Taken together, we provide a comprehensive characterization of a completely blind adult zebrafish mutant with focus on retinal and tectal morphology, as a useful model for glaucoma and optic nerve aplasia.
View article: Blind but alive - congenital loss of<i>atoh7</i>disrupts the visual system of adult zebrafish
Blind but alive - congenital loss of<i>atoh7</i>disrupts the visual system of adult zebrafish Open
1 Abstract Purpose Vision is the predominant sense in most animal species. Loss of vision can be caused by a multitude of factors resulting in anatomical as well as behavioral changes. In mice and zebrafish, atoh7 mutants are completely bl…
View article: Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration
Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration Open
In the lesioned zebrafish retina, Müller glia produce multipotent retinal progenitors that generate all retinal neurons, replacing lost cell types. To study the molecular mechanisms linking Müller glia reactivity to progenitor production a…
View article: Author Response: Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration
Author Response: Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Metrics Abstract In the lesione…
View article: Author Response: Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration
Author Response: Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration Open
In the lesioned zebrafish retina, Müller glia produce multipotent retinal progenitors that generate all retinal neurons, replacing lost cell types. To study the molecular mechanisms linking Müller glia reactivity to progenitor production a…
View article: Reviewer #1 (Public Review): Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration
Reviewer #1 (Public Review): Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration Open
In the lesioned zebrafish retina, Müller glia produce multipotent retinal progenitors that generate all retinal neurons, replacing lost cell types. To study the molecular mechanisms linking Müller glia reactivity to progenitor production a…
View article: Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration
Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration Open
Summary In the lesioned zebrafish retina, Müller glia produce multipotent retinal progenitors that generate all retinal neurons, replacing lost cell types. To study the molecular mechanisms linking Müller glia reactivity to progenitor prod…
View article: Reviewer #2 (Public Review): Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration
Reviewer #2 (Public Review): Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration Open
In the lesioned zebrafish retina, Müller glia produce multipotent retinal progenitors that generate all retinal neurons, replacing lost cell types. To study the molecular mechanisms linking Müller glia reactivity to progenitor production a…
View article: Real-time monitoring of an endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation
Real-time monitoring of an endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation Open
Morphogen gradients impart positional information to cells in a homogenous tissue field. Fgf8a, a highly conserved growth factor, has been proposed to act as a morphogen during zebrafish gastrulation. However, technical limitations have so…
View article: Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish
Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish Open
The vertebrate inner ear is the sensory organ mediating hearing and balance. The entire organ develops from the otic placode, which itself originates from the otic-epibranchial progenitor domain (OEPD). Multiple studies in various species …
View article: Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration
Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration Open
Summary In the lesioned zebrafish retina, Müller glia produce multipotent retinal progenitors that generate all retinal neurons, replacing lost cell types. To study the molecular mechanisms linking Müller glia reactivity to progenitor prod…
View article: Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration
Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration Open
In the lesioned zebrafish retina, Müller glia produce multipotent retinal progenitors that generate all retinal neurons, replacing lost cell types. To study the molecular mechanisms linking Müller glia reactivity to progenitor production a…
View article: Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration
Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration Open
SUMMARY In the lesioned zebrafish retina, Müller glia produce multipotent retinal progenitors that generate all retinal neurons, replacing lost cell types. To study the molecular mechanisms linking Müller glia reactivity to progenitor prod…
View article: Vision-related convergent gene losses reveal SERPINE3’s unknown role in the eye
Vision-related convergent gene losses reveal SERPINE3’s unknown role in the eye Open
Despite decades of research, knowledge about the genes that are important for development and function of the mammalian eye and are involved in human eye disorders remains incomplete. During mammalian evolution, mammals that naturally exhi…
View article: Author response: Vision-related convergent gene losses reveal SERPINE3’s unknown role in the eye
Author response: Vision-related convergent gene losses reveal SERPINE3’s unknown role in the eye Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Despite dec…
View article: Real-time monitoring of endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation
Real-time monitoring of endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation Open
Morphogen gradients impart positional information to cells in a homogenous tissue field. Fgf8a, a highly conserved growth factor, has been proposed to act as a morphogen during zebrafish gastrulation. However, technical limitations have so…
View article: Reactivation of the Neurogenic Niche in the Adult Zebrafish Statoacoustic Ganglion Following a Mechanical Lesion
Reactivation of the Neurogenic Niche in the Adult Zebrafish Statoacoustic Ganglion Following a Mechanical Lesion Open
Sensorineural hearing loss is caused by the loss of sensory hair cells and/or their innervating neurons within the inner ear and affects millions of people worldwide. In mammals, including humans, the underlying cell types are only produce…
View article: Vision-related convergent gene losses reveal <i>SERPINE3</i> ’s unknown role in the eye
Vision-related convergent gene losses reveal <i>SERPINE3</i> ’s unknown role in the eye Open
Despite decades of research, knowledge about the genes that are important for development and function of the mammalian eye and are involved in human eye disorders remains incomplete. During mammalian evolution, mammals that naturally exhi…
View article: Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain
Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain Open
LRRK2 gain-of-function is considered a major cause of Parkinson’s disease (PD) in humans. However, pathogenicity of LRRK2 loss-of-function in animal models is controversial. Here we show that deletion of the entire zebrafish lrrk2 locus el…
View article: Isthmin1, a secreted signaling protein, acts downstream of diverse embryonic patterning centers in development
Isthmin1, a secreted signaling protein, acts downstream of diverse embryonic patterning centers in development Open
Extracellular signals play essential roles during embryonic patterning by providing positional information in a concentration-dependent manner, and many such signals, like Wnt, fibroblast growth factor (FGF), Hedgehog (Hh), and retinoic ac…
View article: Single cell sequencing of radial glia progeny reveals the diversity of newborn neurons in the adult zebrafish brain
Single cell sequencing of radial glia progeny reveals the diversity of newborn neurons in the adult zebrafish brain Open
Zebrafish display widespread and pronounced adult neurogenesis, which is fundamental for their regeneration capability after central nervous system injury. However, the cellular identity and the biological properties of adult newborn neuro…
View article: CRISPR/Cas9-Mediated Zebrafish Knock-in as a Novel Strategy to Study Midbrain-Hindbrain Boundary Development
CRISPR/Cas9-Mediated Zebrafish Knock-in as a Novel Strategy to Study Midbrain-Hindbrain Boundary Development Open
The midbrain-hindbrain boundary (MHB) acts as an organizer and controls the fate of neighboring cells to develop into either mesencephalic (midbrain) or metencephalic (hindbrain) cells by secreting signaling molecules like Wnt1 and Fgf8. T…
View article: Generation of a conditional <i>lima1a</i> allele in zebrafish using the <scp>FLE</scp>x switch technology
Generation of a conditional <i>lima1a</i> allele in zebrafish using the <span>FLE</span>x switch technology Open
Summary Gene trapping has emerged as a valuable tool to create conditional alleles in various model organisms. Here we report the FLEx‐based gene trap vector SAGFLEx that allows the generation of conditional mutations in zebrafish by gene‐…
View article: Subdivisions of the adult zebrafish pallium based on molecular marker analysis
Subdivisions of the adult zebrafish pallium based on molecular marker analysis Open
Background: The telencephalon shows a remarkable structural diversity among vertebrates. In particular, the everted telencephalon of ray-finned fishes has a markedly different morphology compared to the evaginated telencephalon of all othe…
View article: Gene expression analysis in the adult zebrafish pallium
Gene expression analysis in the adult zebrafish pallium Open
Dataset 1 Expression of eomesb in the embryonic brain and the adult pallium in zebrafish.Raw data of Figure S2 and additional image files of eomesb expression in the embryo and the adult pallium. Dataset 2 Images of negative control.No sig…
View article: Asymmetric inheritance of the apical domain and self-renewal of retinal ganglion cell progenitors depend on Anillin function
Asymmetric inheritance of the apical domain and self-renewal of retinal ganglion cell progenitors depend on Anillin function Open
Divisions that generate one neuronal lineage-committed and one self-renewing cell maintain the balance of proliferation and differentiation for the generation of neuronal diversity. The asymmetric inheritance of apical domains and componen…