Anja Ronnenberg
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View article: Transcriptional dynamics of the oligodendrocyte lineage and its regulation by the brain erythropoietin system
Transcriptional dynamics of the oligodendrocyte lineage and its regulation by the brain erythropoietin system Open
Oligodendrocytes differentiate from oligodendrocyte progenitor cells (OPC) in early postnatal development, but some oligodendrogenesis is maintained throughout adulthood, where oligodendrocyte lineage dynamics may contribute to neuroplasti…
View article: Erythropoietin alleviates intellectual disability and autism-like behavior of mice caused by <i>Zbtb20</i> haploinsufficiency, a construct-valid model of Primrose syndrome
Erythropoietin alleviates intellectual disability and autism-like behavior of mice caused by <i>Zbtb20</i> haploinsufficiency, a construct-valid model of Primrose syndrome Open
Among the known genetic causes of syndromic autism spectrum disorders (ASD) are transcription factor deficiencies. In this regard, haploinsufficiency of the ‘zinc finger and broad complex, tramtrack, bric and brac domain-containing protein…
View article: A comprehensive and standardized pipeline for automated profiling of higher cognition in mice
A comprehensive and standardized pipeline for automated profiling of higher cognition in mice Open
In rodent behavior research, observer-independent methods, such as the IntelliCage, enhance data collection in a social, and thus stress-reduced, environment. The IntelliCage system allows experimenters to create cognitive challenges for m…
View article: IntelliR: A comprehensive and standardized pipeline for automated profiling of higher cognition in mice
IntelliR: A comprehensive and standardized pipeline for automated profiling of higher cognition in mice Open
In the rapidly evolving field of rodent behavior research, observer-independent methods facilitate data collection within a social, stress-reduced, and thus more natural environment. A prevalent system in this research area is the IntelliC…
View article: Loss of the parkinsonism‐associated protein <scp>FBXO7</scp> in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects
Loss of the parkinsonism‐associated protein <span>FBXO7</span> in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects Open
Mutations in PARK15 , which encodes for the F‐box protein FBXO7 have been associated with Parkinsonian Pyramidal syndrome, a rare and complex movement disorder with Parkinsonian symptoms, pyramidal tract signs and juvenile onset. Our previ…
View article: Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity
Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity Open
A key feature of advanced brain aging includes structural defects of intracortical myelin that are associated with secondary neuroinflammation. A similar pathology is seen in specific myelin mutant mice that model ‘advanced brain aging’ an…
View article: Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity
Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity Open
A key feature of advanced brain aging includes structural defects of intracortical myelin that are associated with secondary neuroinflammation. A similar pathology is seen in specific myelin mutant mice that model ‘advanced brain aging’ an…
View article: CaMKIIα Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge
CaMKIIα Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge Open
We previously introduced the brain erythropoietin (EPO) circle as a model to explain the adaptive ‘brain hardware upgrade’ and enhanced performance. In this fundamental circle, brain cells, challenged by motor-cognitive tasks, experience f…
View article: Hippocampal neurons respond to brain activity with functional hypoxia
Hippocampal neurons respond to brain activity with functional hypoxia Open
Physical activity and cognitive challenge are established non-invasive methods to induce comprehensive brain activation and thereby improve global brain function including mood and emotional well-being in healthy subjects and in patients. …
View article: Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury
Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury Open
Circulating autoantibodies (AB) of different immunoglobulin classes (IgM, IgA, and IgG), directed against the obligatory N-methyl- d -aspartate-receptor subunit NR1 (NMDAR1-AB), belong to the mammalian autoimmune repertoire, and appear wit…
View article: Vascular response to social cognitive performance measured by infrared thermography: A translational study from mouse to man
Vascular response to social cognitive performance measured by infrared thermography: A translational study from mouse to man Open
To assess complex social recognition in mice, we previously developed the SocioBox paradigm. Unexpectedly, 4 weeks after performing in the SocioBox, mice displayed robust social avoidance during Y‐maze sociability testing. This unique “soc…
View article: Genetically induced brain inflammation by <i>Cnp</i> deletion transiently benefits from microglia depletion
Genetically induced brain inflammation by <i>Cnp</i> deletion transiently benefits from microglia depletion Open
Reduced expression of 2′‐3′‐cyclic nucleotide 3′‐phosphodiesterase ( Cnp ) in humans and mice causes white matter inflammation and catatonic signs. These consequences are experimentally alleviated by microglia ablation via colony‐stimulati…
View article: Hypersocial behavior and biological redundancy in mice with reduced expression of PSD95 or PSD93
Hypersocial behavior and biological redundancy in mice with reduced expression of PSD95 or PSD93 Open
The postsynaptic density proteins 95 (PSD95) and 93 (PSD93) belong to a family of scaffolding proteins, the membrane-associated guanylate kinases (MAGUKs), which are highly enriched in synapses and responsible for organizing the numerous p…
View article: The SocioBox: A Novel Paradigm to Assess Complex Social Recognition in Male Mice
The SocioBox: A Novel Paradigm to Assess Complex Social Recognition in Male Mice Open
Impairments in social skills are central to mental disease, and developing tools for their assessment in mouse models is essential. Here we present the SocioBox, a new behavioral paradigm to measure social recognition. Using this paradigm,…
View article: Selective expression of a constitutively active erythropoietin receptor in <scp>GABA</scp>ergic neurons alters hippocampal network properties without affecting cognition
Selective expression of a constitutively active erythropoietin receptor in <span>GABA</span>ergic neurons alters hippocampal network properties without affecting cognition Open
We have previously shown that treatment with erythropoietin ( EPO ) improves cognition in patients with neuropsychiatric disorders as well as in healthy mice, and that transgenic expression of a constitutively active form of the EPO recept…