Anja Scheller
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Minimal differences observed when comparing the morphological profiling of microglia obtained by confocal laser scanning and optical sectioning microscopy Open
Background While widefield microscopy has long been constrained by out-of-focus scattering, advancements have generated a solution in the form of confocal laser scanning microscopy (cLSM) and optical sectioning microscopy using structured …
Genetic Downregulation of GABAB Receptors from Oligodendrocyte Precursor Cells Protects Against Demyelination in the Mouse Spinal Cord Open
GABAergic signaling and GABAB receptors play crucial roles in regulating the physiology of oligodendrocyte-lineage cells, including their proliferation, differentiation, and myelination. Therefore, they are promising targets for studying h…
View article: Cannabidiol reverses microglia activation and loss of parvalbumin interneurons and perineuronal nets in a mouse model of schizophrenia
Cannabidiol reverses microglia activation and loss of parvalbumin interneurons and perineuronal nets in a mouse model of schizophrenia Open
Cannabidiol (CBD) has shown potential for treating schizophrenia (SCZ) by targeting its positive, negative, and cognitive symptoms. In this study, we investigated if CBD could reverse the memory impairment observed after chronic administra…
View article: Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice
Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice Open
Molecular pathways mediating systemic inflammation entering the brain parenchyma to induce sepsis-associated encephalopathy (SAE) remain elusive. Here, we report that in mice during the first 6 hours of peripheral lipopolysaccharide (LPS)-…
Genetic ablation of GABA <sub>B</sub> receptors from oligodendrocyte precursor cells protects against demyelination in the mouse spinal cord Open
GABAergic signaling and GABA B receptors play crucial roles in regulating the physiology of oligodendrocyte-lineage cells, including their proliferation, differentiation, and myelination. Therefore, they are promising targets for studying …
Neuronal lysosome transfer to oligodendrocyte precursor cells: a novel mechanism of neuron-glia communication and its role in neurodegenerative diseases Open
Oligodendrocyte precursor cells (OPCs) shape brain function through intricate regulatory mechanisms. Here, we observed that OPC processes establish connections with neuronal somata, with smaller lysosomes positioned near these contact site…
View article: Adenosine triggers early astrocyte reactivity that provokes microglial activation and drives the pathogenesis of sepsis-associated encephalopathy
Adenosine triggers early astrocyte reactivity that provokes microglial activation and drives the pathogenesis of sepsis-associated encephalopathy Open
Summary Molecular pathways mediating systemic inflammation entering the brain parenchyma to induce sepsis-associated encephalopathy (SAE) remain elusive. Here, we report that in mice during the first 6 hours of peripheral lipopolysaccharid…
View article: Novel algorithms for improved detection and analysis of fluorescent signal fluctuations
Novel algorithms for improved detection and analysis of fluorescent signal fluctuations Open
Fluorescent dyes and genetically encoded fluorescence indicators (GEFI) are common tools for visualizing concentration changes of specific ions and messenger molecules during intra- as well as intercellular communication. Using advanced im…
View article: Novel algorithms for improved detection and analysis of fluorescent signal fluctuations
Novel algorithms for improved detection and analysis of fluorescent signal fluctuations Open
Fluorescent dyes and genetically encoded fluorescence indicators (GEFI) are common tools for visualizing concentration changes of specific ions and messenger molecules during intra- as well as intercellular communication. Using advanced im…
Neocytolysis after return from high altitude (5100 m): Further evidence for absentia Open
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LPS-Induced Systemic Inflammation Affects the Dynamic Interactions of Astrocytes and Microglia with the Vasculature of the Mouse Brain Cortex Open
The Neurovascular Unit (NVU), composed of glia (astrocytes, oligodendrocytes, microglia), neurons, pericytes and endothelial cells, is a dynamic interface ensuring the physiological functioning of the central nervous system (CNS), which ge…
LPS-Induced Systemic Inflammation Affects the Dynamic Interactions of Astrocytes and Microglia with the Vasculature of the Mouse Brain Cortex Open
The Neurovascular Unit (NVU), comprised of glia (astrocytes, oligodendrocytes, microglia), neurons, pericytes and endothelial cells, is a dynamic interface ensuring physiological functioning of the central nervous system (CNS), that gets a…
View article: Microglial morphology in the somatosensory cortex across lifespan. A quantitative study
Microglial morphology in the somatosensory cortex across lifespan. A quantitative study Open
Background Microglia are long‐lived cells that constantly monitor their microenvironment. To accomplish this task, they constantly change their morphology both in the short and long term under physiological conditions. This makes the proce…
Study of Effector CD8+ T Cell Interactions with Cortical Neurons in Response to Inflammation in Mouse Brain Slices and Neuronal Cultures Open
Cytotoxic CD8+ T cells contribute to neuronal damage in inflammatory and degenerative CNS disorders, such as multiple sclerosis (MS). The mechanism of cortical damage associated with CD8+ T cells is not well understood. We developed in vit…
A subset of <span>OPCs</span> do not express Olig2 during development which can be increased in the adult by brain injuries and complex motor learning Open
Oligodendrocyte precursor cells (OPCs) are uniformly distributed in the mammalian brain; however, their function is rather heterogeneous in respect to their origin, location, receptor/channel expression and age. The basic helix–loop–helix …
View article: Cannabidiol Exerts a Neuroprotective and Glia-Balancing Effect in the Subacute Phase of Stroke
Cannabidiol Exerts a Neuroprotective and Glia-Balancing Effect in the Subacute Phase of Stroke Open
Pharmacological agents limiting secondary tissue loss and improving functional outcomes after stroke are still limited. Cannabidiol (CBD), the major non-psychoactive component of Cannabis sativa, has been proposed as a neuroprotective agen…
TREM2 Is Associated with Advanced Stages and Inferior Prognosis in Oral Squamous Cell Carcinoma Open
Triggering receptor expressed on myeloid cells 2 (TREM2) is suggested to hamper antitumor immune response in multiple cancers. However, the role of TREM2 in oral squamous cell carcinoma (OSCC) and its expression in tumor-associated macroph…
Pathology-induced NG2 proteoglycan expression in microglia Open
Oligodendrocyte precursor cells (OPCs) and microglia are two very fascinating cell types with a multitude of important but different functions. At a first glance, they appear not to share many cellular properties, nor are directly related …
Specific detection and deletion of the sigma‐1 receptor widely expressed in neurons and glial cells in vivo Open
The chaperon protein sigma‐1 receptor (S1R) has been discovered over 40 years ago. Recent pharmacological studies using S1R exogenous ligands demonstrated a promising therapeutical potential of targeting the S1R in several neurological dis…
View article: Novel algorithms for improved detection and analysis of fluorescent signal fluctuations
Novel algorithms for improved detection and analysis of fluorescent signal fluctuations Open
Fluorescent dyes and genetically encoded fluorescence indicators (GEFI) are common tools for visualizing concentration changes of specific ions and messenger molecules during intra-as well as intercellular communication. Using advanced ima…
Brain injuries and complex motor learning suppress Olig2 in a subpopulation of oligodendrocyte precursor cells Open
Oligodendrocyte precursor cells (OPCs) are uniformly distributed in the mammalian brain, however their function is rather heterogeneous in respect to their origin, location, receptor/channel expression and age. The basic helix-loop-helix t…
Specific detection and deletion of the Sigma-1 receptor in neurons and glial cells for functional characterization <i>in vivo</i> Open
The chaperon protein sigma-1 receptor (S1R) has been discovered over forty years ago. Recent pharmacological studies using S1R exogenous ligands demonstrated a promising therapeutical potential of targeting the S1R for several neurological…
View article: Time-lapse Imaging of Microglial Activity and Astrocytic Calcium Signaling Reveals a Neuroprotective Effect of Cannabidiol in the Subacute Phase of Stroke
Time-lapse Imaging of Microglial Activity and Astrocytic Calcium Signaling Reveals a Neuroprotective Effect of Cannabidiol in the Subacute Phase of Stroke Open
Pharmacological agents that limit secondary tissue loss and/or improve functional outcomes after stroke are still limited. Cannabidiol, the major non-psychoactive component of Cannabis sativa , has been proposed as a neuroprotective agent …
Astrocytes and Microglia Exhibit Cell-Specific Ca2+ Signaling Dynamics in the Murine Spinal Cord Open
The spinal cord is the main pathway connecting brain and peripheral nervous system. Its functionality relies on the orchestrated activity of both neurons and glial cells. To date, most advancement in understanding the spinal cord inner mec…