Anja Sofie Petersen
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View article: International Headache society evidence-based guidelines on the use of non-invasive neuromodulation devices for the acute and preventive treatment of migraine
International Headache society evidence-based guidelines on the use of non-invasive neuromodulation devices for the acute and preventive treatment of migraine Open
Objective To develop evidence-based clinical practice guidelines for non-invasive neuromodulation devices in acute and preventive migraine treatment. Methods A systematic review was conducted across six databases from 1946 to April 2025. R…
View article: <scp>PACAP</scp>‐38 in Cluster Headache: A Prospective, Case–Control Study of a Potential Treatment Target
<span>PACAP</span>‐38 in Cluster Headache: A Prospective, Case–Control Study of a Potential Treatment Target Open
Background Estimates of pituitary adenylate cyclase‐activating peptide‐38's (PACAP‐38) activity in cluster headache are sparse. We investigated whether plasma levels of PACAP‐38 differ between disease states (i.e., bout, remission, chronic…
View article: Exploring medication-overuse and medication-overuse headache in cluster headache
Exploring medication-overuse and medication-overuse headache in cluster headache Open
Background It is not well established to what extent medication-overuse occurs in cluster headache (CH), if medication-overuse headache exists in CH and whether the existing criteria for medication-overuse headache are a suitable diagnosti…
View article: Uncovering drug targets for cluster headache through proteome-wide Mendelian randomization analysis
Uncovering drug targets for cluster headache through proteome-wide Mendelian randomization analysis Open
View article: From Tics to Stabs: Renaming Cluster Tics in Cluster Headache—A Cross‐Sectional Study
From Tics to Stabs: Renaming Cluster Tics in Cluster Headache—A Cross‐Sectional Study Open
Background Short‐lasting paroxysms of facial pain in patients with cluster headache have traditionally been called “cluster tics.” Mostly described as co‐occurring trigeminal neuralgia, they remain to be explored as an independent phenomen…
View article: Transition of cluster headache: Depicting side-changing attacks as a chronic trait in an interview-based follow-up study
Transition of cluster headache: Depicting side-changing attacks as a chronic trait in an interview-based follow-up study Open
Background Cluster headache presents in an episodic and chronic form, between which patients can convert during the course of disease. We aimed to quantify the rate of cluster headache patients changing phenotype within one and five years …
View article: Compensated Hypogonadism Identified in Males with Cluster Headache: A Prospective Case‐Controlled Study
Compensated Hypogonadism Identified in Males with Cluster Headache: A Prospective Case‐Controlled Study Open
Objective Androgens have been hypothesized to be involved in the pathophysiology of cluster headache due to the male predominance, but whether androgens are altered in patients with cluster headache remains unclear. Methods We performed a …
View article: Reduced plasma calcitonin gene-related peptide level identified in cluster headache: A prospective and controlled study
Reduced plasma calcitonin gene-related peptide level identified in cluster headache: A prospective and controlled study Open
Background The role of calcitonin gene-related peptide (CGRP) in the cyclic pattern of cluster headache is unclear. To acquire biological insight and to comprehend why only episodic cluster headache responds to CGRP monoclonal antibodies, …
View article: Effects of psilocybin and sleep quality on brain water diffusivity and microstructure in healthy individuals and chronic cluster headache patients
Effects of psilocybin and sleep quality on brain water diffusivity and microstructure in healthy individuals and chronic cluster headache patients Open
View article: Biomarkers in cluster headache: A systematic review
Biomarkers in cluster headache: A systematic review Open
Objective To systematically investigate previously examined biomarkers in blood, urine, cerebrospinal fluid, tear fluid, and saliva of patients with cluster headache. Background Cluster headache is a condition with extensive clinical chall…
View article: The HortONS study. Treatment of chronic cluster headache with transcutaneous electrical nerve stimulation and occipital nerve stimulation: study protocol for a prospective, investigator-initiated, double-blinded, randomized, placebo-controlled trial
The HortONS study. Treatment of chronic cluster headache with transcutaneous electrical nerve stimulation and occipital nerve stimulation: study protocol for a prospective, investigator-initiated, double-blinded, randomized, placebo-controlled trial Open
Background Chronic cluster headache (CCH) is a debilitating primary headache disorder. Occipital nerve stimulation (ONS) has shown the potential to reduce attack frequency, but the occipital paresthesia evoked by conventional (tonic) stimu…
View article: Current treatment options for cluster headache: limitations and the unmet need for better and specific treatments—a consensus article
Current treatment options for cluster headache: limitations and the unmet need for better and specific treatments—a consensus article Open
Aim Treatment for cluster headache is currently based on a trial-and-error approach. The available preventive treatment is unspecific and based on few and small studies not adhering to modern standards. Therefore, the authors collaborated …
View article: Cluster Headache Genomewide Association Study and Meta‐Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor
Cluster Headache Genomewide Association Study and Meta‐Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor Open
Objective The objective of this study was to aggregate data for the first genomewide association study meta‐analysis of cluster headache, to identify genetic risk variants, and gain biological insights. Methods A total of 4,777 cases (3,34…
View article: Cluster headache polygenetic risk and known functional variants of <scp><i>CYP3A4</i></scp> are not associated with treatment response
Cluster headache polygenetic risk and known functional variants of <span><i>CYP3A4</i></span> are not associated with treatment response Open
Background and purpose The response to cluster headache treatments has a high interindividual variation. To date, treatment response has only been assessed by a candidate gene approach and no investigations into metabolic pathways have bee…
View article: Transition of cluster headache phenotype: An interview-based study
Transition of cluster headache phenotype: An interview-based study Open
Background Cluster headache exists diagnostically in a chronic and episodic variant between which patients can convert. We aimed to describe how many patients change phenotype, elucidate possible factors associated with this transition and…
View article: Debate: Are cluster headache and migraine distinct headache disorders?
Debate: Are cluster headache and migraine distinct headache disorders? Open
View article: Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity
Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity Open
Chronic cluster headache (CCH) is an excruciating disorder of unknown pathophysiology, but hypothalamic dysfunction has been implicated. CCH is difficult to treat but on a case-basis, the psychedelic compound psilocybin is said to have ben…
View article: The economic and personal burden of cluster headache: a controlled cross-sectional study
The economic and personal burden of cluster headache: a controlled cross-sectional study Open
View article: Issue Information
Issue Information Open
View article: Sphenopalatine ganglion stimulation for cluster headache, results from a large, open-label European registry
Sphenopalatine ganglion stimulation for cluster headache, results from a large, open-label European registry Open
View article: Does post-exercise hypokalemia increase risk of arrhythmias?
Does post-exercise hypokalemia increase risk of arrhythmias? Open
View article: Sleep and chronobiology in cluster headache
Sleep and chronobiology in cluster headache Open
Background and aim M.R. present address: PAIN, National Institutes of Health, Bethesda, MD, USA Cluster headache (CH) is the headache disorder with the strongest chronobiological traits. The severe attacks of pain occur with diurnal and an…