Anjing Chen
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View article: Unveiling the immunopharmacological mechanisms of Danggui Yinzi (DGYZ) in treating chronic urticaria: insights from network pharmacology and experimental validation
Unveiling the immunopharmacological mechanisms of Danggui Yinzi (DGYZ) in treating chronic urticaria: insights from network pharmacology and experimental validation Open
Background Chronic urticaria (CU), a prevalent and often debilitating allergic skin disorder, is primarily triggered by mast cell degranulation. Danggui Yinzi (DGYZ), a traditional Chinese medicine formula, has been employed to treat pruri…
View article: Integrated 4D label-free proteome and SUMOylated proteome in glioma uncover novel pathological mechanisms and pave the way for precision therapy
Integrated 4D label-free proteome and SUMOylated proteome in glioma uncover novel pathological mechanisms and pave the way for precision therapy Open
Glioma, the most common primary intracranial tumor, has seen increased scrutiny with the advent of high-throughput detection technologies, yet many aspects of its tumorigenesis and progression remain enigmatic. In this study, we utilized 4…
View article: Mitochondrial Energy Homeostasis and Membrane Interaction Regulate the Rapid Growth of Moso Bamboo
Mitochondrial Energy Homeostasis and Membrane Interaction Regulate the Rapid Growth of Moso Bamboo Open
The rapid growth of moso bamboo is primarily attributed to the swift elongation of its internodes. While mitochondria are known to provide energy for various cellular processes, the specific mechanisms by which they facilitate rapid growth…
View article: Old players and new insights: unraveling the role of RNA-binding proteins in brain tumors
Old players and new insights: unraveling the role of RNA-binding proteins in brain tumors Open
The human genome harbors >1,600 evolutionarily conserved RNA-binding proteins (RBPs), with extensive multi-omics investigations documenting their pervasive dysregulation in malignancies ranging from glioblastoma to melanoma. These RBPs are…
View article: Construction and Comparison of Machine Learning-Based Risk Prediction Models for Major Adverse Cardiovascular Events in Perimenopausal Women
Construction and Comparison of Machine Learning-Based Risk Prediction Models for Major Adverse Cardiovascular Events in Perimenopausal Women Open
The RF model showed good performance in predicting the risk of MACE in perimenopausal women providing a reference for the early identification of high-risk patients and the development of targeted intervention strategies.
View article: Heavy metals concentrations in commercial organic fertilizers and the potential risk of fertilization into soils
Heavy metals concentrations in commercial organic fertilizers and the potential risk of fertilization into soils Open
Inductively coupled plasma mass spectrometry (ICP-MS) was used to detect heavy metals in 74 typical and representative commercial organic fertilizers (COFs) collected in major COF production areas in China. The potential risk of fertilizat…
View article: SUMOylation modification of HNRNPK at the K422 site promotes invasion in glioblastoma
SUMOylation modification of HNRNPK at the K422 site promotes invasion in glioblastoma Open
Glioblastoma multiforme (GBM) is a highly heterogeneous brain tumor with limited treatment options. Recent studies revealed cellular heterogeneity and the potential for interconversion between distinct cell types on the basis of RNA sequen…
View article: Genetic insights into the gut microbiota and risk of facial skin aging: A Mendelian randomization study
Genetic insights into the gut microbiota and risk of facial skin aging: A Mendelian randomization study Open
Background A growing number of experimental studies have shown an association between the gut microbiota (GM) and facial skin aging. However, the causal relationship between GM and facial skin aging remains unclear to date. Methods We cond…
View article: Protective effect of paeoniflorin in diabetic nephropathy: A preclinical systematic review revealing the mechanism of action
Protective effect of paeoniflorin in diabetic nephropathy: A preclinical systematic review revealing the mechanism of action Open
Background Paeoniflorin (PF), the main active glucoside of Paeonia Lactiflora, has many pharmacological activities, such as inhibition of vasodilation, hypoglycemia, and immunomodulation. Although the current evidence has suggested the the…
View article: BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma
BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma Open
There is an urgent need for novel diagnostic and therapeutic strategies for patients with Glioblastoma multiforme (GBM). Previous studies have shown that BCL2 like 13 (BCL2L13) is a member of the BCL2 family regulating cell growth and apop…
View article: Comprehensive analysis of PSMD family members and validation of PSMD9 as a potential therapeutic target in human glioblastoma
Comprehensive analysis of PSMD family members and validation of PSMD9 as a potential therapeutic target in human glioblastoma Open
Aims PSMD family members, as important components of the 26S proteasome, are well known to be involved in protein degradation. However, their role in glioblastoma (GBM) has not been rigorously investigated. We aimed to perform systematic a…
View article: The application of exosomes in the early diagnosis and treatment of osteoarthritis
The application of exosomes in the early diagnosis and treatment of osteoarthritis Open
With the increase in human lifespan and the aggravation of global aging, the incidence of osteoarthritis (OA) is increasing annually. To better manage and control the progression of OA, prompt diagnosis and treatment for early-stage OA are…
View article: Editorial: The advances in proteomics and targeted therapy of malignant brain tumours
Editorial: The advances in proteomics and targeted therapy of malignant brain tumours Open
EDITORIAL article Front. Oncol., 25 April 2023Sec. Neuro-Oncology and Neurosurgical Oncology Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1195847
View article: Supplementary Table S8 from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling
Supplementary Table S8 from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling Open
Association between ACTN4 expression and clinicopathological factors in glioma
View article: Supplementary Table S1 from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling
Supplementary Table S1 from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling Open
Clinical data for individual patients
View article: Supplementary Table S7 from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling
Supplementary Table S7 from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling Open
Most significant decreasing protein partners of HNRNPL after SChLAP1 knockdown
View article: Authorship Change forms from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling
Authorship Change forms from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling Open
Authorship Change forms
View article: Supplementary Materials and Methods from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling
Supplementary Materials and Methods from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling Open
Supplementary Materials and Methods
View article: Supplementary Table S5 from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling
Supplementary Table S5 from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling Open
Association between SChLAP1 expression and clinicopathological factors in glioma
View article: Data from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling
Data from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling Open
Purpose:Long noncoding RNAs (lncRNA) have essential roles in diverse cellular processes, both in normal and diseased cell types, and thus have emerged as potential therapeutic targets. A specific member of this family, the SWI/SNF complex …
View article: Supplementary Table S5 from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling
Supplementary Table S5 from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling Open
Association between SChLAP1 expression and clinicopathological factors in glioma
View article: Supplementary Figures from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling
Supplementary Figures from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling Open
Supplementary Figures S1-S7
View article: Supplementary Table S6 from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling
Supplementary Table S6 from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling Open
Proteins binding with SChLAP1 sense and antisense
View article: Supplementary Table S2-S4 from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling
Supplementary Table S2-S4 from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling Open
Oligonucleotide sets used, Plasmids used and Primer sets used in this study