Anke Baranowsky
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View article: Spatio-temporal characterization of compositional and cellular properties in the murine fracture callus
Spatio-temporal characterization of compositional and cellular properties in the murine fracture callus Open
Advances in the understanding of the physiological process of bone healing and its impairment (i.e., nonunion) require appropriate models and precise standardization. The femoral osteotomy and external fixation mouse model meets these requ…
View article: Bone metabolism in heterotopic ossification is primarily influenced by the time after trauma or surgery, independent of anatomic location
Bone metabolism in heterotopic ossification is primarily influenced by the time after trauma or surgery, independent of anatomic location Open
Although several risk factors and prophylactic measures for heterotopic ossification (HO) have been identified in the past, knowledge about its growth and metabolic activity over time remains limited. This study aimed to identify specific …
View article: Cxcl9-deficiency attenuates the progression of post-traumatic osteoarthritis in mice
Cxcl9-deficiency attenuates the progression of post-traumatic osteoarthritis in mice Open
View article: Reconstructing skeletal homeostasis through allogeneic hematopoietic stem cell transplantation in myelofibrosis
Reconstructing skeletal homeostasis through allogeneic hematopoietic stem cell transplantation in myelofibrosis Open
View article: Corrigendum: The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells
Corrigendum: The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells Open
[This corrects the article DOI: 10.3389/fendo.2024.1392418.].
View article: The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells
The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells Open
Bone is a dynamic tissue that is constantly remodeled throughout adult life. Recently, it has been shown that bone turnover decreases shortly after food consumption. This process has been linked to the fermentation of non-digestible food i…
View article: Arthroscopic Shaver-based Harvest of Minced Cartilage Results in Reduced Chondrocyte Viability and Reduced Quality of Cartilaginous Repair Tissue Compared With Open Harvest and Conventional Fragmentation
Arthroscopic Shaver-based Harvest of Minced Cartilage Results in Reduced Chondrocyte Viability and Reduced Quality of Cartilaginous Repair Tissue Compared With Open Harvest and Conventional Fragmentation Open
On the basis of our findings, arthroscopic harvest of minced cartilage leads to reduced chondrocyte viability and ReCT quality. Accordingly, CMC and AMC cannot be regarded as synonymous techniques, as arthroscopic techniques seem to be les…
View article: The emerging role of tranexamic acid and its principal target, plasminogen, in skeletal health
The emerging role of tranexamic acid and its principal target, plasminogen, in skeletal health Open
View article: Transcript-dependent effects of the CALCA gene on the progression of post-traumatic osteoarthritis in mice
Transcript-dependent effects of the CALCA gene on the progression of post-traumatic osteoarthritis in mice Open
View article: Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development
Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development Open
Piezo proteins are mechanically activated ion channels, which are required for mechanosensing functions in a variety of cell types. While we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells …
View article: Tranexamic Acid Attenuates the Progression of Posttraumatic Osteoarthritis in Mice
Tranexamic Acid Attenuates the Progression of Posttraumatic Osteoarthritis in Mice Open
Background: Posttraumatic osteoarthritis (OA) is a common disorder associated with a high socioeconomic burden, particularly in young, physically active, and working patients. Tranexamic acid (TXA) is commonly used in orthopaedic trauma su…
View article: The Biological Effects of Magnesium-Based Implants on the Skeleton and Their Clinical Implications in Orthopedic Trauma Surgery
The Biological Effects of Magnesium-Based Implants on the Skeleton and Their Clinical Implications in Orthopedic Trauma Surgery Open
Magnesium (Mg)-based implants have evolved as a promising innovation in orthopedic trauma surgery, with the potential to revolutionize the treatment of bone diseases, including osteoporotic fractures and bone defects. Available clinical st…
View article: The selective norepinephrine reuptake inhibitor reboxetine promotes late-stage fracture healing in mice
The selective norepinephrine reuptake inhibitor reboxetine promotes late-stage fracture healing in mice Open
View article: Increased beta2-adrenergic signaling is a targetable stimulus essential for bone healing by promoting callus neovascularization
Increased beta2-adrenergic signaling is a targetable stimulus essential for bone healing by promoting callus neovascularization Open
Traumatic brain injury (TBI) is associated with a hyperadrenergic state and paradoxically causes systemic bone loss while accelerating fracture healing. Here, we identify the beta2-adrenergic receptor (Adrb2) as a central mediator of these…
View article: Fracture healing in a mouse model of Hajdu–Cheney-Syndrome with high turnover osteopenia results in decreased biomechanical stability
Fracture healing in a mouse model of Hajdu–Cheney-Syndrome with high turnover osteopenia results in decreased biomechanical stability Open
View article: Efficacy of zoledronic acid for the elimination of disseminated tumor cells in a clinically relevant, spontaneously metastatic prostate cancer xenograft model
Efficacy of zoledronic acid for the elimination of disseminated tumor cells in a clinically relevant, spontaneously metastatic prostate cancer xenograft model Open
Bone metastases develop in >90 % of patients with castration-resistant prostate cancer (PCa) through complex interactions between the bone microenvironment and tumor cells. Previous androgen-deprivation therapy (ADT), which is known to cau…
View article: Increased concentrations of conjugated bile acids are associated with osteoporosis in PSC patients
Increased concentrations of conjugated bile acids are associated with osteoporosis in PSC patients Open
View article: Inactivation of beta2-adrenergic signaling improves bone regeneration
Inactivation of beta2-adrenergic signaling improves bone regeneration Open
View article: The chemokine Cxcl9 is a crucial regulator of bone healing
The chemokine Cxcl9 is a crucial regulator of bone healing Open
View article: The gap junction protein Panx3 is essential for bone regeneration+
The gap junction protein Panx3 is essential for bone regeneration+ Open
View article: RAI2 as a novel suppressor of cancer cell homing and survival in the bone microenvironment
RAI2 as a novel suppressor of cancer cell homing and survival in the bone microenvironment Open
View article: Pharmacological inhibition of norepinephrine reuptake improves late-stage fracture healing but exerts adverse effects on intact bone
Pharmacological inhibition of norepinephrine reuptake improves late-stage fracture healing but exerts adverse effects on intact bone Open
View article: Cold exposure has a negative impact on bone mass in vivo
Cold exposure has a negative impact on bone mass in vivo Open
View article: G6b-B regulates an essential step in megakaryocyte maturation
G6b-B regulates an essential step in megakaryocyte maturation Open
G6b-B is a megakaryocyte lineage-specific immunoreceptor tyrosine-based inhibition motif–containing receptor, essential for platelet homeostasis. Mice with a genomic deletion of the entire Mpig6b locus develop severe macrothrombocytopenia …
View article: Systemic calcitonin gene-related peptide receptor antagonism decreases survival in a porcine model of polymicrobial sepsis: blinded randomised controlled trial
Systemic calcitonin gene-related peptide receptor antagonism decreases survival in a porcine model of polymicrobial sepsis: blinded randomised controlled trial Open
View article: Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment
Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment Open
Intermittent injections of parathyroid hormone (iPTH) are applied clinically to stimulate bone formation by osteoblasts, although continuous elevation of parathyroid hormone (PTH) primarily results in increased bone resorption. Here, we id…
View article: Spine Metastases in Immunocompromised Mice after Intracardiac Injection of MDA-MB-231-SCP2 Breast Cancer Cells
Spine Metastases in Immunocompromised Mice after Intracardiac Injection of MDA-MB-231-SCP2 Breast Cancer Cells Open
Breast cancer cells frequently metastasize to bone, where their interaction with bone remodeling cell types enhances osteolytic bone destruction. Importantly, however, whereas skeletal analyses of xenograft models are usually restricted to…
View article: Tumor cell E-selectin ligands determine partialefficacy of bortezomib on spontaneous lung metastasis formation of solid human tumors in vivo
Tumor cell E-selectin ligands determine partialefficacy of bortezomib on spontaneous lung metastasis formation of solid human tumors in vivo Open
Extravasation of circulating tumor cells (CTCs) is critical for metastasis and is initiated by adhesive interactions between glycoligands on CTCs and E-selectin on endothelia. Here, we show that the clinically approved proteasome inhibitor…
View article: The calcitonin receptor protects against bone loss and excessive inflammation in collagen antibody-induced arthritis
The calcitonin receptor protects against bone loss and excessive inflammation in collagen antibody-induced arthritis Open
View article: Mice Lacking the Calcitonin Receptor Do Not Display Improved Bone Healing
Mice Lacking the Calcitonin Receptor Do Not Display Improved Bone Healing Open
Despite significant advances in surgical techniques, treatment options for impaired bone healing are still limited. Inadequate bone regeneration is not only associated with pain, prolonged immobilization and often multiple revision surgeri…