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View article: A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration
A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration Open
Bone regeneration after fracture is a complex process with high and dynamic energy demands. The impact of metabolism on bone healing progression and outcome, however, is so far understudied. Our comprehensive molecular profiling reveals th…
View article: High glucose impairs osteogenic differentiation of embryonic stem cells via early diversion of beta‐catenin from Forkhead box O to T cell factor interaction
High glucose impairs osteogenic differentiation of embryonic stem cells via early diversion of beta‐catenin from Forkhead box O to T cell factor interaction Open
Background Diabetes, which is characterized by an increase in blood glucose concentration, is accompanied by low bone turnover, increased fracture risk, and the formation of embryonic skeletal malformations. Yet, there are few studies eluc…
View article: Alginate Hydrogels for <i>In Vivo</i> Bone Regeneration: The Immune Competence of the Animal Model Matters
Alginate Hydrogels for <i>In Vivo</i> Bone Regeneration: The Immune Competence of the Animal Model Matters Open
Biomaterials with tunable biophysical properties hold great potential for tissue engineering. The adaptive immune system plays an important role in bone regeneration. Our goal is to investigate the regeneration potential of cell-laden algi…
View article: Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function
Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function Open
Fracture repair is initiated by a multitude of immune cells and induction of an inflammatory cascade. Alterations in the early healing response due to an aged adaptive immune system leads to impaired bone repair, delayed healing or even fo…
View article: Circulating dipeptidyl peptidase 3 is a myocardial depressant factor: dipeptidyl peptidase 3 inhibition rapidly and sustainably improves haemodynamics
Circulating dipeptidyl peptidase 3 is a myocardial depressant factor: dipeptidyl peptidase 3 inhibition rapidly and sustainably improves haemodynamics Open
Aims Acute heart failure is a high mortality disease and its pathophysiology is not completely understood. Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in angiotensin II and enkephalins cleavage. The aim of this study was t…
View article: A novel and highly efficient purification procedure for native human dipeptidyl peptidase 3 from human blood cell lysate
A novel and highly efficient purification procedure for native human dipeptidyl peptidase 3 from human blood cell lysate Open
Dipeptidyl amino-peptidase 3 (DPP3) is an aminopeptidase involved in peptide degradation, including hormone peptides as angiotensin II and enkephalins. DPP3 plasma activity increases in septic patients and correlates with mortality risk. H…
View article: Biophysical induction of cell release for minimally manipulative cell enrichment strategies
Biophysical induction of cell release for minimally manipulative cell enrichment strategies Open
The use of autologous cells harvested and subsequently transplanted in an intraoperative environment constitutes a new approach to promote regeneration. Usually cells are isolated by selection methods such as fluorescence- or magnetic- act…
View article: Regulatory T cell-mediated anti-inflammatory effects promote successful tissue repair in both indirect and direct manners
Regulatory T cell-mediated anti-inflammatory effects promote successful tissue repair in both indirect and direct manners Open
Regulatory T cells (Tregs) offer new immunotherapeutic options to control undesired immune reactions, such as those in transplant rejection and autoimmunity. In addition, tissue repair and regeneration depend on a multitude of tightly regu…
View article: Accumulation of Amino-Polyvinyl Alcohol-Coated Superparamagnetic Iron Oxide Nanoparticles in Bone Marrow: Implications for Local Stromal Cells
Accumulation of Amino-Polyvinyl Alcohol-Coated Superparamagnetic Iron Oxide Nanoparticles in Bone Marrow: Implications for Local Stromal Cells Open
A-PVA-SPIONs appear suitable for contrast enhancement in bone marrow while our data suggest an influence on the BMSCs biology that necessitates future research.