Anke Geng
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View article: Sirt2 ablation exacerbates Sod1 knockout-induced progeroid phenotype in mice
Sirt2 ablation exacerbates Sod1 knockout-induced progeroid phenotype in mice Open
The free radical theory of aging suggests that oxidative stress from free radicals contributes to aging. While free radicals cause DNA damage and cellular dysfunction, they also regulate essential signaling pathways. This duality complicat…
View article: Enhancing low-dose radiotherapy efficacy with PARP inhibitors via FBL-mediated oxidative stress response in colorectal cancer
Enhancing low-dose radiotherapy efficacy with PARP inhibitors via FBL-mediated oxidative stress response in colorectal cancer Open
View article: The transcription factor PAX5 activates human LINE1 retrotransposons to induce cellular senescence
The transcription factor PAX5 activates human LINE1 retrotransposons to induce cellular senescence Open
As a hallmark of senescent cells, the derepression of Long Interspersed Elements 1 (LINE1) transcription results in accumulated LINE1 cDNA, which triggers the secretion of the senescence-associated secretory phenotype (SASP) and paracrine …
View article: SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner
SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner Open
Sirtuin 2 (SIRT2) regulates the maintenance of genome integrity by targeting pathways of DNA damage response and homologous recombination repair. However, whether and how SIRT2 promotes base excision repair (BER) remain to be determined. H…
View article: Tanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repair
Tanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repair Open
Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumors with increasing incidence rates and high mortality rates. The currently available methods for treating HCC include surgery, radiotherapy or chemotherapy, bu…
View article: Chrysin impairs genomic stability by suppressing DNA double-strand break repair in breast cancer cells
Chrysin impairs genomic stability by suppressing DNA double-strand break repair in breast cancer cells Open
Chrysin, a natural compound isolated from various plants, such as the blue passion flower (Passiflora caerulea L.), exhibits multiple pharmacological activities, such as antitumor, anti-inflammatory and antioxidant activities. Accum…
View article: Chrysin impairs genomic stability by suppressing DNA double-strand break repair in breast cancer cells
Chrysin impairs genomic stability by suppressing DNA double-strand break repair in breast cancer cells Open
Chrysin, a natural compound isolated from various plants, such as the blue passion flower (Passiflora caerulea L.), exhibits multiple pharmacological activities, such as antitumor, anti-inflammatory and antioxidant activities. Accum…
View article: Chrysin impairs genomic stability by suppressing DNA double-strand break repair in breast cancer cells
Chrysin impairs genomic stability by suppressing DNA double-strand break repair in breast cancer cells Open
Chrysin, a natural compound isolated from various plants, such as the blue passion flower (Passiflora caerulea L.), exhibits multiple pharmacological activities, such as antitumor, anti-inflammatory and antioxidant activities. Accum…
View article: Activated or Impaired: An Overview of DNA Repair in Neurodegenerative Diseases
Activated or Impaired: An Overview of DNA Repair in Neurodegenerative Diseases Open
As the population ages, age-related neurodegenerative diseases have become a major challenge in health science. Currently, the pathology of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral s…
View article: Diosmetin enhances the sensitivity of radiotherapy by suppressing homologous recombination in endometrial cancer
Diosmetin enhances the sensitivity of radiotherapy by suppressing homologous recombination in endometrial cancer Open
Radiotherapy is an essential treatment for endometrial cancer (EC), especially in advanced, metastatic, and recurrent cases. Combining radiotherapy, which mainly causes DNA double-strand breaks (DSBs), with small molecules targeting aberra…
View article: Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors
Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors Open
Significance Hepatocellular carcinoma (HCC) is the sixth most common type of cancer, and its mortality rate continues to increase. We generated knock-in reporter mouse models for measuring DNA double-strand break (DSB) repair efficiency an…
View article: The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2
The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2 Open
The NAD+-dependent deacetylase and mono-ADP-ribosyl transferase SIRT6 stabilizes the genome by promoting DNA double strand break repair, thereby acting as a tumor suppressor. However, whether SIRT6 regulates nucleotide excision repair (NER…
View article: Diosmetin enhances the sensitivity of radiotherapy by suppressing homologous recombination in endometrial cancer
Diosmetin enhances the sensitivity of radiotherapy by suppressing homologous recombination in endometrial cancer Open
Radiotherapy is an essential treatment for endometrial cancer (EC), especially in advanced, metastatic, and recurrent cases. Combining radiotherapy, which mainly causes DNA double-strand breaks (DSBs), with small molecules targeting aberra…
View article: Base excision repair but not DNA double‐strand break repair is impaired in aged human adipose‐derived stem cells
Base excision repair but not DNA double‐strand break repair is impaired in aged human adipose‐derived stem cells Open
The decline in DNA repair capacity contributes to the age‐associated decrease in genome integrity in somatic cells of different species. However, due to the lack of clinical samples and appropriate tools for studying DNA repair, whether an…
View article: Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion
Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion Open
View article: <i>Pd<scp>EPF</scp>1</i> regulates water‐use efficiency and drought tolerance by modulating stomatal density in poplar
<i>Pd<span>EPF</span>1</i> regulates water‐use efficiency and drought tolerance by modulating stomatal density in poplar Open
Summary Water deficiency is a critical environmental condition that is seriously reducing global plant production. Improved water‐use efficiency ( WUE ) and drought tolerance are effective strategies to address this problem. In this study,…