Anke Hoellig
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View article: Monitoring treatment of delayed cerebral ischaemia in unconscious patients after aneurysmal subarachnoid haemorrhage: a prospective multimodal neuromonitoring study
Monitoring treatment of delayed cerebral ischaemia in unconscious patients after aneurysmal subarachnoid haemorrhage: a prospective multimodal neuromonitoring study Open
Background Aneurysmal subarachnoid haemorrhage (SAH) is a life-threatening condition with high morbidity. Delayed cerebral ischaemia (DCI) significantly contributes to secondary injury and poor outcomes. While perfusion CT (CTP) aids DCI d…
View article: Single-nucleus RNA sequencing: immature excitatory neurons and transformed glia build human BRAFV600E-negative gangliogliomas
Single-nucleus RNA sequencing: immature excitatory neurons and transformed glia build human BRAFV600E-negative gangliogliomas Open
Gangliogliomas are glioneuronal neoplasms, generally with a benign evolution, accounting for the most common tumors in patients with long-term pharmacoresistant epilepsy. BRAFV600E has been detected in a high percentage of World Health Org…
View article: A Closer Look at Potential Underlying Factors Related to Possible Disparity Between Sexes in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage
A Closer Look at Potential Underlying Factors Related to Possible Disparity Between Sexes in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage Open
Background: Aneurysmal subarachnoid hemorrhage (SAH) is over twice as common in females compared to males, who may also experience more severe hemorrhages and worse outcomes. Differences in SAH severity, susceptibility to delayed cerebral …
View article: What makes the human brain special: from cellular function to clinical translation
What makes the human brain special: from cellular function to clinical translation Open
What makes the human brain special? Human neurons, glia cells, and cortical circuits have been shown to be significantly different from those of other species, including mammals. This has led to a massive effort by the neuroscience communi…
View article: Cost-effectiveness of population-wide screening for intracranial aneurysms revisited in light of potential diagnostic developments
Cost-effectiveness of population-wide screening for intracranial aneurysms revisited in light of potential diagnostic developments Open
Background: Preventive treatment of unruptured intracranial aneurysms (UIAs) has the potential to reduce aneurysmal subarachnoid hemorrhage (SAH) incidence. Population-wide screening (PWS) for UIAs has been disregarded, as it remains uncle…
View article: Iron Hemostasis in Patients With Subarachnoid Hemorrhage and the Role of Early CSF Drainage
Iron Hemostasis in Patients With Subarachnoid Hemorrhage and the Role of Early CSF Drainage Open
Early brain injury and delayed cerebral ischemia are combined intricate processes, and they represent the principal cause of subarachnoid hemorrhage (SAH)-related morbidity and mortality worldwide. Recent studies have shown that early lumb…
View article: The metabolic and autoregulatory profile of reversible delayed cerebral ischemia in unconscious patients after aneurysmal subarachnoid hemorrhage: a prospective multimodal neuromonitoring cohort study
The metabolic and autoregulatory profile of reversible delayed cerebral ischemia in unconscious patients after aneurysmal subarachnoid hemorrhage: a prospective multimodal neuromonitoring cohort study Open
Background The detection and treatment of delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (SAH) remain challenging. Multimodal neuromonitoring and CT perfusion scanning (CTP) are promising tools for diagnosing …
View article: Flexible 3D <i>Kirigami</i> Probes for In Vitro and In Vivo Neural Applications
Flexible 3D <i>Kirigami</i> Probes for In Vitro and In Vivo Neural Applications Open
3D microelectrode arrays (MEAs) are gaining popularity as brain–machine interfaces and platforms for studying electrophysiological activity. Interactions with neural tissue depend on the electrochemical, mechanical, and spatial features of…
View article: Comprehensive analysis of human dendritic spine morphology and density
Comprehensive analysis of human dendritic spine morphology and density Open
This study presents a dataset of nearly 4,000 morphologically reconstructed human dendritic spines across different ages, gender, and tissue conditions. The dataset was further used to evaluate a deep learning algorithm for three-dimension…
View article: Mapping Inflammatory Markers in Cerebrospinal Fluid Following Aneurysmal Subarachnoid Hemorrhage: An Age- and Sex-Matched Analysis
Mapping Inflammatory Markers in Cerebrospinal Fluid Following Aneurysmal Subarachnoid Hemorrhage: An Age- and Sex-Matched Analysis Open
Despite extensive research on aneurysm treatment and neurocritical care, aneurysmal subarachnoid hemorrhage (SAH) is still a life-threatening disease, often leaving survivors with lasting neurological and cognitive impairments. Early brain…
View article: Flexible 3D kirigami probes for in vitro and in vivo neural applications
Flexible 3D kirigami probes for in vitro and in vivo neural applications Open
Three-dimensional (3D) microelectrode arrays (MEAs) are gaining popularity as brain-machine interfaces and platforms for studying electrophysiological activity. Interactions with neural tissue depend on the electrochemical, mechanical, and…
View article: Value of Glycemic Indices for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: A Retrospective Single-Center Study
Value of Glycemic Indices for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: A Retrospective Single-Center Study Open
Delayed cerebral ischemia (DCI) is a severe complication following aneurysmal subarachnoid hemorrhage (aSAH), linked to poor functional outcomes and prolonged intensive care unit (ICU) stays. Timely DCI diagnosis is crucial but remains cha…
View article: Effects of Angiotensin-Converting Enzyme Inhibition on the Recurrence and Internal Structure of Chronic Subdural Hematomas
Effects of Angiotensin-Converting Enzyme Inhibition on the Recurrence and Internal Structure of Chronic Subdural Hematomas Open
Background/Objectives: Chronic subdural hematoma (cSDH) is a common disease of growing significance due to the increasing use of antithrombotic drugs and population aging. There exists conflicting observational evidence that previous treat…
View article: Aneurysmal Subarachnoid Hemorrhage in Hospitalized Patients on Anticoagulants—A Two Center Matched Case-Control Study
Aneurysmal Subarachnoid Hemorrhage in Hospitalized Patients on Anticoagulants—A Two Center Matched Case-Control Study Open
Objective—Direct oral anticoagulants (DOAC) are replacing vitamin K antagonists (VKA) for the prevention of ischemic stroke and venous thromboembolism. We set out to assess the effect of prior treatment with DOAC and VKA in patients with a…
View article: Seizure after surgical treatment of chronic subdural hematoma—Associated factors and effect on outcome
Seizure after surgical treatment of chronic subdural hematoma—Associated factors and effect on outcome Open
Introduction Chronic subdural hematoma (cSDH) is becoming more prevalent due to population aging and the increasing use of antithrombotic drugs. Postoperative seizure in cSDH have a negative effect on outcome, and there currently no consen…
View article: Revisiting the Timeline of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: Toward a Temporal Risk Profile
Revisiting the Timeline of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: Toward a Temporal Risk Profile Open
Background Delayed cerebral ischemia (DCI) is one of the main determinants of clinical outcome after aneurysmal subarachnoid hemorrhage (SAH). The classical description of risk for DCI over time is currently based on the outdated concept o…
View article: Decompressive hemicraniectomy after aneurysmal subarachnoid hemorrhage—justifiable in light of long-term outcome?
Decompressive hemicraniectomy after aneurysmal subarachnoid hemorrhage—justifiable in light of long-term outcome? Open
Purpose Decompressive hemicraniectomy (DHC) is a potentially lifesaving procedure in refractory intracranial hypertension, which can prevent death from brainstem herniation but may cause survival in a disabled state. The spectrum of indica…
View article: Invasive Multimodal Neuromonitoring in Aneurysmal Subarachnoid Hemorrhage: A Systematic Review
Invasive Multimodal Neuromonitoring in Aneurysmal Subarachnoid Hemorrhage: A Systematic Review Open
Background and Purpose: Aneurysmal subarachnoid hemorrhage is a devastating disease leaving surviving patients often severely disabled. Delayed cerebral ischemia (DCI) has been identified as one of the main contributors to poor clinical ou…
View article: Body mass index and leptin levels in serum and cerebrospinal fluid in relation to delayed cerebral ischemia and outcome after aneurysmal subarachnoid hemorrhage
Body mass index and leptin levels in serum and cerebrospinal fluid in relation to delayed cerebral ischemia and outcome after aneurysmal subarachnoid hemorrhage Open
Aneurysmal subarachnoid hemorrhage (SAH) is associated with a high mortality rate and may leave surviving patients severely disabled. After the initial hemorrhage, clinical outcome is further compromised by the occurrence of delayed cerebr…
View article: Body Mass Index and Leptin Levels in Serum and Cerebrospinal Fluid in Relation to Delayed Cerebral Ischemia and Outcome after Aneurysmal Subarachnoid Hemorrhage
Body Mass Index and Leptin Levels in Serum and Cerebrospinal Fluid in Relation to Delayed Cerebral Ischemia and Outcome after Aneurysmal Subarachnoid Hemorrhage Open
ObjectiveAneurysmal subarachnoid hemorrhage (SAH) is associated with a high mortality rate and may leave surviving patients severely disabled. After the initial hemorrhage, clinical outcome is further compromised by the occurrence of delay…
View article: Retinal Vessel Analysis (RVA) in the Context of Subarachnoid Hemorrhage - A Proof of Concept Study
Retinal Vessel Analysis (RVA) in the Context of Subarachnoid Hemorrhage - A Proof of Concept Study Open
RVA is technically feasible in patients with SAH and can detect fluctuations in vessel diameter and autoregulation even in less severely affected patients. Preliminary data suggests potential for RVA as a new and non-invasive tool for adva…