Anke Höllig
YOU?
Author Swipe
View article: An Unusual Presentation of Peri‐Lead Edema Following Deep Brain Stimulation for Parkinson's Disease: A Case Report and Review of the Literature
An Unusual Presentation of Peri‐Lead Edema Following Deep Brain Stimulation for Parkinson's Disease: A Case Report and Review of the Literature Open
Peri‐lead edema (PLE) after deep brain stimulation may mimic brain infection on magnetic resonance imaging (MRI). We present a case of symptomatic PLE with annular contrast enhancement on MRI suggestive of an infectious cause. We show that…
View article: Microsurgical management of cranial dural arteriovenous fistulas: Treating the “Sheep in Wolf's clothing”? – Three decades of experience and lessons learned
Microsurgical management of cranial dural arteriovenous fistulas: Treating the “Sheep in Wolf's clothing”? – Three decades of experience and lessons learned Open
Microsurgery is an immediate, safe, and effective treatment option for dAVFs.
View article: Intraoperative Intermittent Pneumatic Compression Reduces Incidence of Venous Thromboembolism in Patients Undergoing Craniotomy: Study Protocol of a Randomized Multicenter, Single-Blind Trial
Intraoperative Intermittent Pneumatic Compression Reduces Incidence of Venous Thromboembolism in Patients Undergoing Craniotomy: Study Protocol of a Randomized Multicenter, Single-Blind Trial Open
BACKGROUND AND OBJECTIVE: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common complication in craniotomy patients. The duration of surgery has been identified as a risk factor fo…
View article: Morphotype-specific calcium signaling in human microglia
Morphotype-specific calcium signaling in human microglia Open
Background Key functions of Ca 2+ signaling in rodent microglia include monitoring the brain state as well as the surrounding neuronal activity and sensing the danger or damage in their vicinity. Microglial Ca 2+ dyshomeostasis is a diseas…
View article: Morphotype-specific calcium signaling in human microglia
Morphotype-specific calcium signaling in human microglia Open
Key functions of Ca 2+ signaling in rodent microglia include monitoring the brain state or the surrounding neuronal activity and sensing the danger or damage in their vicinity. Microglial Ca 2+ dyshomeostasis is a disease hallmark in many …
View article: Secondary Ischemia Assessment in Murine and Rat Preclinical Subarachnoid Hemorrhage Models: A Systematic Review
Secondary Ischemia Assessment in Murine and Rat Preclinical Subarachnoid Hemorrhage Models: A Systematic Review Open
Background Delayed cerebral ischemia represents a significant contributor to death and disability following aneurysmal subarachnoid hemorrhage. Although preclinical models have shown promising results, clinical trials have consistently fai…
View article: Elevated concentrations of macrophage migration inhibitory factor in serum and cerebral microdialysate are associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
Elevated concentrations of macrophage migration inhibitory factor in serum and cerebral microdialysate are associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage Open
Objective Inflammation is increasingly recognized to be involved in the pathophysiology of aneurysmal subarachnoid hemorrhage (aSAH) and may increase the susceptibility to delayed cerebral ischemia (DCI). Macrophage migration inhibitory fa…
View article: Results of Temporary Stent-assisted Coil Embolization (CATS) for the Treatment of Wide-neck Aneurysms
Results of Temporary Stent-assisted Coil Embolization (CATS) for the Treatment of Wide-neck Aneurysms Open
Purpose In intracranial wide-neck aneurysms, simple coil embolization is often not a feasible treatment option. Balloon-assisted coiling comes with the drawback of blood flow impairment, whereas permanent stent placement requires long-term…
View article: Procedural and Methodological Quality in Preclinical Stroke Research–A Cohort Analysis of the Rat MCAO Model Comparing Periods Before and After the Publication of STAIR/ARRIVE
Procedural and Methodological Quality in Preclinical Stroke Research–A Cohort Analysis of the Rat MCAO Model Comparing Periods Before and After the Publication of STAIR/ARRIVE Open
The translation of preclinical stroke research into successful human clinical trials remains a challenging task. The first Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for preclinical research and several other guide…
View article: A Retrospective Analysis of Randomized Controlled Trials on Traumatic Brain Injury: Evaluation of CONSORT Item Adherence
A Retrospective Analysis of Randomized Controlled Trials on Traumatic Brain Injury: Evaluation of CONSORT Item Adherence Open
Traumatic brain injury (TBI) contributes to death and disability, resulting in an enormous individual and socio-economic challenges. Despite huge efforts, there are still controversies on treatment strategies and early outcome estimation. …
View article: Female Participation in Academic European Neurosurgery—A Cross-Sectional Analysis
Female Participation in Academic European Neurosurgery—A Cross-Sectional Analysis Open
The study aims to provide data on authors’ gender distribution with special attention on publications from Europe. Articles (October 2019–March 2020) published in three representative neurosurgical journals (Acta Neurochirurgica, Journal o…
View article: Failed Neuroprotection of Combined Inhibition of L-Type and ASIC1a Calcium Channels with Nimodipine and Amiloride
Failed Neuroprotection of Combined Inhibition of L-Type and ASIC1a Calcium Channels with Nimodipine and Amiloride Open
Effective pharmacological neuroprotection is one of the most desired aims in modern medicine. We postulated that a combination of two clinically used drugs—nimodipine (L-Type voltage-gated calcium channel blocker) and amiloride (acid-sensi…
View article: Predicting experimental success: a retrospective case-control study using the rat intraluminal thread model of stroke
Predicting experimental success: a retrospective case-control study using the rat intraluminal thread model of stroke Open
The poor translational success rate of preclinical stroke research may partly be due to inaccurate modelling of the disease. We provide data on transient middle cerebral artery occlusion (tMCAO) experiments, including detailed intraoperati…
View article: Procalcitonin in the context of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
Procalcitonin in the context of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage Open
OBJECTIVE Aneurysmal subarachnoid hemorrhage (aSAH) initiates a deleterious cascade activating multiple inflammatory processes, which can contribute to delayed cerebral ischemia (DCI). Procalcitonin (PCT) is an established marker for sepsi…
View article: An altered posterior question-mark incision is associated with a reduced infection rate of cranioplasty after decompressive hemicraniectomy
An altered posterior question-mark incision is associated with a reduced infection rate of cranioplasty after decompressive hemicraniectomy Open
OBJECTIVE Performing a cranioplasty (CP) after decompressive craniotomy is a straightforward neurosurgical procedure, but it remains associated with a high complication rate. Surgical site infection (SSI), aseptic bone resorption (aBR), an…
View article: Argon treatment after experimental subarachnoid hemorrhage: evaluation of microglial activation and neuronal survival as a subanalysis of a randomized controlled animal trial
Argon treatment after experimental subarachnoid hemorrhage: evaluation of microglial activation and neuronal survival as a subanalysis of a randomized controlled animal trial Open
Hereinafter, we evaluate argon's neuroprotective and immunomodulatory properties after experimental subarachnoid hemorrhage (SAH) examining various localizations (hippocampal and cortical regions) with respect to neuronal damage and microg…
View article: Randomized Controlled Trials on Intracerebral Hemorrhage: A Cross Sectional Retrospective Analysis of CONSORT Item Adherence
Randomized Controlled Trials on Intracerebral Hemorrhage: A Cross Sectional Retrospective Analysis of CONSORT Item Adherence Open
Object: Intracranial hemorrhage (ICH) is the second most common cause of stroke but still there is little consolidated knowledge about the optimal treatment strategies (e.g., the benefit of surgical evacuation). We evaluated the current ra…
View article: Argon treatment alters microglial activation and neuronal cell death after experimental subarachnoid hemorrhage – a randomized controlled animal trial
Argon treatment alters microglial activation and neuronal cell death after experimental subarachnoid hemorrhage – a randomized controlled animal trial Open
Background Here, we demonstrate argon´s neuroprotective and immunomodulatory properties after experimental subarachnoid hemorrhage (SAH) examining various localizations (hippocampal and cortical regions) with respect to neuronal damage and…
View article: A 6-step Approach to Gain Higher Quality Results From Organotypic Hippocampal Brain Slices in a Traumatic Brain Injury Model
A 6-step Approach to Gain Higher Quality Results From Organotypic Hippocampal Brain Slices in a Traumatic Brain Injury Model Open
Results in a TBI experiment on OHBS should be analyzed critically as inhomogeneities may occur. In order to ensure more precise findings, a structured approach of comparing the results should be followed. Further research is recommended to…
View article: Time Courses of Inflammatory Markers after Aneurysmal Subarachnoid Hemorrhage and Their Possible Relevance for Future Studies
Time Courses of Inflammatory Markers after Aneurysmal Subarachnoid Hemorrhage and Their Possible Relevance for Future Studies Open
We estimate that the wide range of the measured values hampers their interpretation and usage as a biomarker. However, understanding the inflammatory response after aSAH and generating a multicenter database may facilitate further studies:…
View article: Xenon Reduces Neuronal Hippocampal Damage and Alters the Pattern of Microglial Activation after Experimental Subarachnoid Hemorrhage: A Randomized Controlled Animal Trial
Xenon Reduces Neuronal Hippocampal Damage and Alters the Pattern of Microglial Activation after Experimental Subarachnoid Hemorrhage: A Randomized Controlled Animal Trial Open
In animals treated with 50 vol% xenon (for 1 h) after SAH, a less pronounced neuronal damage was observed for the ipsilateral hippocampal regions CA3 and DG, when compared to the control group. In xenon-treated animals, a lower microglial …
View article: Variation of blood injection velocity in a new experimental model of non-aneurysmal SAH: any influence on intracranial pressure and cerebral perfusion in the acute phase?
Variation of blood injection velocity in a new experimental model of non-aneurysmal SAH: any influence on intracranial pressure and cerebral perfusion in the acute phase? Open
Introduction: Aneurysmal subarachnoid hemorrhage (aSAH) is hallmarked by rapid increase of intracranial pressure (ICP) and acute hypoperfusion contributing to early brain injury. Non-aneurysmal SAH (naSAH) is assumed to result in less dram…
View article: Argon attenuates the emergence of secondary injury after traumatic brain injury within a 2-hour incubation period compared to desflurane: an in vitro study
Argon attenuates the emergence of secondary injury after traumatic brain injury within a 2-hour incubation period compared to desflurane: an in vitro study Open
Despite years of research, treatment of traumatic brain injury (TBI) remains challenging. Considerable data exists that some volatile anesthetics might be neuroprotective. However, several studies have also revealed a rather neurotoxic pro…
View article: Desflurane impairs outcome of organotypic hippocampal slices in an in vitro model of traumatic brain injury
Desflurane impairs outcome of organotypic hippocampal slices in an in vitro model of traumatic brain injury Open
Decreased mortality and disability after traumatic brain injury is a significant medical challenge. Desflurane, a widely used volatile anesthetic has proven to be neuroprotective in a variety of in vitro and in vivo models of ischemic brai…