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View article: Association between maternal organophosphate flame retardants (OPFRs) metabolite levels during pregnancy and internalizing and externalizing behaviors in children at 2-5 years
Association between maternal organophosphate flame retardants (OPFRs) metabolite levels during pregnancy and internalizing and externalizing behaviors in children at 2-5 years Open
Background Organophosphorus flame retardants (OPFRs) metabolites are frequently detected in human samples. Their structural similarity to polybrominated diphenyl ethers raises concerns about potential neurotoxicity. Animal and limited huma…
View article: Cell type-specific methylome-wide association studies of childhood ADHD symptoms
Cell type-specific methylome-wide association studies of childhood ADHD symptoms Open
Studying DNA methylation (DNAm) can provide insights into gene-regulatory mechanisms underlying attention-deficit/hyperactivity disorder (ADHD). While most DNAm studies were performed in bulk tissue, this study used statistical deconvoluti…
View article: Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium
Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium Open
Epigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about ho…
View article: Metabolic dysregulation in Alzheimer's disease: A brain metabolomics approach
Metabolic dysregulation in Alzheimer's disease: A brain metabolomics approach Open
INTRODUCTION This study aimed to identify specific biological pathways and molecules involved in Alzheimer's disease (AD) neuropathology. METHODS We conducted cutting‐edge high‐resolution metabolomics profiling of 162 human frontal cortex …
View article: Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood
Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood Open
Maternal sustained smoking has the largest impact on newborn DNA methylation, suggesting a strong influence of the intrauterine environment. We observed minimal impacts for less studied exposures including SHS, maternal former smoking and …
View article: Association of social and environmental exposures at the neighborhood level with child brain volume
Association of social and environmental exposures at the neighborhood level with child brain volume Open
We identified multiple social and environmental factors in association with greater right caudal middle frontal gyrus volume. These results provide evidence of how multiple facets of the neighborhood environment can impact the developing b…
View article: Epigenome‐wide association study of cerebrospinal fluid–based biomarkers of Alzheimer's disease in cognitively normal individuals
Epigenome‐wide association study of cerebrospinal fluid–based biomarkers of Alzheimer's disease in cognitively normal individuals Open
INTRODUCTION Cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are reliable predictors of future AD risk. We investigated whether pre‐clinical changes in AD CSF biomarkers are reflected in blood DNA methylation (DNAm) levels…
View article: Unraveling the Molecular Links between Fine Particulate Matter Exposure and Early Birth Risks in African American Mothers: A Metabolomics Study in the Atlanta African American Maternal-Child Cohort
Unraveling the Molecular Links between Fine Particulate Matter Exposure and Early Birth Risks in African American Mothers: A Metabolomics Study in the Atlanta African American Maternal-Child Cohort Open
In the United States, African Americans (AA) are disproportionately exposed to elevated levels of ambient fine particulate matter (PM2.5) while suffering from the highest rates of early births. To elucidate the largely unknown underlying m…
View article: Joint effects of environmental and neighborhood socioeconomic factors on cognitive function in the Heinz Nixdorf Recall Study
Joint effects of environmental and neighborhood socioeconomic factors on cognitive function in the Heinz Nixdorf Recall Study Open
We identified associations between distinct combinations of intercorrelated air pollution, road traffic noise, and nSEP disadvantages with poorer cognitive function, using two different dimensionality reduction methods. Our findings highli…
View article: Childhood Asthma and Allergy Are Related to Accelerated Epigenetic Aging
Childhood Asthma and Allergy Are Related to Accelerated Epigenetic Aging Open
Background Few studies showed associations of childhood allergic diseases with epigenetic aging using traditional clocks trained mainly on adults. Tracking DNA methylation variation early in life has suggested poor performance of these clo…
View article: Maternal asthma and newborn DNA methylation
Maternal asthma and newborn DNA methylation Open
Background Prenatal exposure to maternal asthma may influence DNA methylation patterns in offspring, potentially affecting their susceptibility to later diseases including asthma. Objective To investigate the relationship between parental …
View article: Differential DNA methylation in blood as potential mediator of the association between ambient PM<sub>2.5</sub>and cerebrospinal fluid biomarkers of Alzheimer’s disease among a cognitively normal population-based cohort
Differential DNA methylation in blood as potential mediator of the association between ambient PM<sub>2.5</sub>and cerebrospinal fluid biomarkers of Alzheimer’s disease among a cognitively normal population-based cohort Open
Introduction Fine particulate matter (PM 2.5 ) is a known risk factor for Alzheimer’s disease (AD), with emerging evidence linking PM 2.5 exposure to cerebrospinal fluid (CSF) biomarkers in pre-clinical stages. However, the role of DNA met…
View article: Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium
Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium Open
Background DNA methylation (DNAm) is a developmentally dynamic epigenetic process; yet, most epigenome-wide association studies (EWAS) have examined DNAm at only one timepoint or without systematic comparisons between timepoints. Thus, it …
View article: Sensitive periods for exposure to indoor air pollutants and psychosocial factors in association with symptoms of psychopathology at school-age in a South African birth cohort
Sensitive periods for exposure to indoor air pollutants and psychosocial factors in association with symptoms of psychopathology at school-age in a South African birth cohort Open
Exposure to environmental toxicants and psychosocial stressors during gestation and early life are particularly harmful and may impact brain development. Specifically, exposure to indoor air pollutants (IAP) and psychosocial factors (PF) d…
View article: Interaction between Neighborhood Exposome and Genetic Risk in Child Psychotic-like Experiences
Interaction between Neighborhood Exposome and Genetic Risk in Child Psychotic-like Experiences Open
Persistent distressing psychotic-like experiences (PLE) among children may be driven by genetics and neighborhood environmental exposures. However, the gene-environment interaction to persistent distressing PLE is unknown. The study includ…
View article: Epigenome-wide association study of cerebrospinal fluid-based biomarkers of Alzheimer’s disease in cognitively normal individuals
Epigenome-wide association study of cerebrospinal fluid-based biomarkers of Alzheimer’s disease in cognitively normal individuals Open
INTRODUCTION Cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD) are reliable predictors of future AD risk. We investigated whether pre-clinical changes in AD CSF biomarkers are reflected in blood DNA methylation (DNAm) levels…
View article: Exposure profiles of social-environmental neighborhood factors and persistent distressing psychotic-like experiences across four years among young adolescents in the US
Exposure profiles of social-environmental neighborhood factors and persistent distressing psychotic-like experiences across four years among young adolescents in the US Open
Background Recent research has demonstrated that domains of social determinants of health (SDOH) (e.g. air pollution and social context) are associated with psychosis. However, SDOHs have often been studied in isolation. This study investi…
View article: Maximizing insights from longitudinal epigenetic age data: simulations, applications, and practical guidance
Maximizing insights from longitudinal epigenetic age data: simulations, applications, and practical guidance Open
Background Epigenetic age (EA) is an age estimate, developed using DNA methylation (DNAm) states of selected CpG sites across the genome. Although EA and chronological age are highly correlated, EA may not increase uniformly with time. Dep…
View article: Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium
Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium Open
Children born via cesarean delivery have a higher risk of metabolic, immunological, and neurodevelopmental disorders compared to those born via vaginal delivery, although mechanisms remain unclear. We conducted a meta-analysis of epigenome…
View article: Associations between prenatal exposure to environmental phenols and child neurodevelopment at two years of age in a South African birth cohort
Associations between prenatal exposure to environmental phenols and child neurodevelopment at two years of age in a South African birth cohort Open
Across all methods, we found no association between individual phenol exposures or the joint exposure mixture with the cognitive score. Prenatal tobacco exposure modified the association between pentachlorophenol (PCP) and cognitive neurod…
View article: Investigating interaction effects of social risk factors and exposure to air pollution on pediatric lymphoma cancer in Georgia, United States
Investigating interaction effects of social risk factors and exposure to air pollution on pediatric lymphoma cancer in Georgia, United States Open
Childhood cancer constitutes a major cause of death in children. In a recent study of the Georgia Cancer Registry, joint exposures to environmental and social/behavioral stressors were associated with spatial clustering of lymphomas and re…
View article: Epigenetic associations with neonatal age in infants born very preterm, particularly among genes involved in neurodevelopment
Epigenetic associations with neonatal age in infants born very preterm, particularly among genes involved in neurodevelopment Open
The time from conception through the first year of life is the most dynamic period in human development. This time period is particularly important for infants born very preterm (< 30 weeks gestation; VPT), as they experience a significant…
View article: Epigenetic Age Acceleration and Disparities in Posttraumatic Stress in Women in Southeast Louisiana
Epigenetic Age Acceleration and Disparities in Posttraumatic Stress in Women in Southeast Louisiana Open
Importance Disasters experienced by an entire community provide opportunities to understand individual differences in risk for adverse health outcomes over time. DNA methylation (DNAm) differences may help to distinguish individuals at inc…
View article: Maximizing Insights from Longitudinal Epigenetic Age Data: Simulations, Applications, and Practical Guidance
Maximizing Insights from Longitudinal Epigenetic Age Data: Simulations, Applications, and Practical Guidance Open
Background Epigenetic Age (EA) is an age estimate, developed using DNA methylation (DNAm) states of selected CpG sites across the genome. Although EA and chronological age are highly correlated, EA may not increase uniformly with time. Dep…