Anke Kaltbeitzel
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View article: Protein corona fingerprinting of exocytosed nanoparticles reveals time-dependence of exocytosis pathways
Protein corona fingerprinting of exocytosed nanoparticles reveals time-dependence of exocytosis pathways Open
In the field of nano-bio interactions, the cellular uptake of nanocarriers and the modulating factors, e.g. the presence of a protein shell - the protein corona - adsorbed on the nanocarrier surface are well studied. However, little is kno…
View article: Intracellular Formation of Synthetic Peptide Nanostructures Causes Mitochondrial Disruption and Cell Death in Tumor Spheroids
Intracellular Formation of Synthetic Peptide Nanostructures Causes Mitochondrial Disruption and Cell Death in Tumor Spheroids Open
Supramolecular assemblies found in nature demonstrate the concept of creating functionality through structure formation. In recent years, these complex natural architectures have inspired the development of materials for the formation of s…
View article: Intracellular assembly of supramolecular peptide nanostructures controlled by visible light
Intracellular assembly of supramolecular peptide nanostructures controlled by visible light Open
The complex dynamics of synthetic supramolecular systems in living cellular environments impede the correlation between the transient hierarchical species and their biological functions. Achieving this correlation demands a breakthrough th…
View article: Nanoparticle characterisation <i>via</i> 2D classification using single particle averaging
Nanoparticle characterisation <i>via</i> 2D classification using single particle averaging Open
A versatile method for image-based determination of a particle size distribution, based on a 2D classification approach.
View article: Intracellular Formation of Synthetic Peptide Nanostructures Causes Mitochondrial Disruption and Cell Death in Tumor Spheroids
Intracellular Formation of Synthetic Peptide Nanostructures Causes Mitochondrial Disruption and Cell Death in Tumor Spheroids Open
Supramolecular assemblies found in nature demonstrate the concept of creating functionality through structure formation. In recent years, these complex natural architectures have inspired the development of materials for the formation of s…
View article: Supramolecular Assembly in Live Cells Mapped by Real-Time Phasor-Fluorescence Lifetime Imaging
Supramolecular Assembly in Live Cells Mapped by Real-Time Phasor-Fluorescence Lifetime Imaging Open
The complex dynamics and transience of assembly pathways in living systems complicate the understanding of these molecular to nanoscale processes. Current technologies are unable to track the molecular events leading to the onset of assemb…
View article: Phasor-Fluorescence Lifetime Imaging Correlates Dynamics of in-situ Amyloid Nanostructures to Respiratory Dysfunction
Phasor-Fluorescence Lifetime Imaging Correlates Dynamics of in-situ Amyloid Nanostructures to Respiratory Dysfunction Open
The complex dynamics and transience of molecular aggregation pathways leading to amyloid-based neurodegeneration complicate the mechanistic understanding of these fatal diseases. Current technologies are unable to track the molecular proce…
View article: Correlative Microscopy for the Identification of Intracellular Nanoparticles and their Cellular Processing
Correlative Microscopy for the Identification of Intracellular Nanoparticles and their Cellular Processing Open
Journal Article Correlative Microscopy for the Identification of Intracellular Nanoparticles and their Cellular Processing Get access Ingo Lieberwirth, Ingo Lieberwirth Max-Planck Institute for Polymer Research, Mainz, Germany Correspondin…
View article: Nanoscale Control of the Surface Functionality of Polymeric 2D Materials
Nanoscale Control of the Surface Functionality of Polymeric 2D Materials Open
Typically, 2D nanosheets have a homogeneous surface, making them a major challenge to structure. This study proposes a novel concept of 2D organic nanosheets with a heterogeneously functionalized surface. This work achieves this by consecu…
View article: Endosomal sorting results in a selective separation of the protein corona from nanoparticles
Endosomal sorting results in a selective separation of the protein corona from nanoparticles Open
The formation of the protein corona is a well-known effect when nanoparticles (NP) are exposed to biological environments. The protein corona is the most important factor, which determines the rate and route of endocytosis, and decisively …
View article: In Situ Assembly of Platinum(II)-Metallopeptide Nanostructures Disrupts Energy Homeostasis and Cellular Metabolism
In Situ Assembly of Platinum(II)-Metallopeptide Nanostructures Disrupts Energy Homeostasis and Cellular Metabolism Open
Nanostructure-based functions are omnipresent in nature and essential for the diversity of life. Unlike small molecules, which are often inhibitors of enzymes or biomimetics with established methods of elucidation, we show that functions o…
View article: In Situ Assembly of Platinum (II)-Metallopeptide Nanostructures Inhibits Energy Homeostasis and Cellular Metabolism
In Situ Assembly of Platinum (II)-Metallopeptide Nanostructures Inhibits Energy Homeostasis and Cellular Metabolism Open
Nanostructure-based functions are omnipresent in nature and essential for the diversity of life. Unlike small molecules, which are often inhibitors of enzymes or biomimetics with established methods of elucidation, we show that functions o…
View article: Nanocarriers Made of Proteins: Intracellular Visualization of a Smart Biodegradable Drug Delivery System
Nanocarriers Made of Proteins: Intracellular Visualization of a Smart Biodegradable Drug Delivery System Open
This work analyzes the intracellular fate of protein‐based nanocarriers along their endolysosomal pathway by means of correlative light and electron microscopy methods. To unambiguously identify the nanocarriers and their degradation remna…
View article: Surface Properties of Colloidal Particles Affect Colloidal Self-Assembly in Evaporating Self-Lubricating Ternary Droplets
Surface Properties of Colloidal Particles Affect Colloidal Self-Assembly in Evaporating Self-Lubricating Ternary Droplets Open
In this work, we unravel the role of surface properties of colloidal particles on the formation of supraparticles (clusters of colloidal particles) in a colloidal Ouzo droplet. Self-lubricating colloidal Ouzo droplets are an efficient and …
View article: Platinum (II) Nanofibers as Assembly-driven Inhibitors of Metabolic Adaptation in Cancer Cells
Platinum (II) Nanofibers as Assembly-driven Inhibitors of Metabolic Adaptation in Cancer Cells Open
Nanostructure-based functions are omnipresent in biology and essential for the diversity of life. Despite their importance, it is difficult to establish mechanisms that define their bioactivity and rationalize them through synthetic design…
View article: How a water drop removes a particle from a hydrophobic surface
How a water drop removes a particle from a hydrophobic surface Open
Possible outcomes when a particle collides with a water drop on a hydrophobic surface.
View article: Adaptive Wetting of Polydimethylsiloxane
Adaptive Wetting of Polydimethylsiloxane Open
To better understand the wetting of cross-linked polydimethylsiloxane (PDMS), we measured advancing and receding contact angles of sessile water drops on cross-linked PDMS as a function of contact line velocity (up to 100 μm/s). Three type…
View article: Submicrometer-Sized Roughness Suppresses Bacteria Adhesion
Submicrometer-Sized Roughness Suppresses Bacteria Adhesion Open
Biofilm formation is most commonly combatted with antibiotics or biocides. However, proven toxicity and increasing resistance of bacteria increase the need for alternative strategies to prevent adhesion of bacteria to surfaces. Chemical mo…
View article: Microdroplet Contaminants: When and Why Superamphiphobic Surfaces Are Not Self-Cleaning
Microdroplet Contaminants: When and Why Superamphiphobic Surfaces Are Not Self-Cleaning Open
Superamphiphobic surfaces are commonly associated with superior anticontamination and antifouling properties. Visually, this is justified by their ability to easily shed off drops and contaminants. However, on micropillar arrays, tiny drop…
View article: When and how self-cleaning of superhydrophobic surfaces works
When and how self-cleaning of superhydrophobic surfaces works Open
We monitor the self-cleaning process on a single-particle level and quantify the involved forces.
View article: One-Step Preparation of Fuel-Containing Anisotropic Nanocapsules with Stimuli-Regulated Propulsion
One-Step Preparation of Fuel-Containing Anisotropic Nanocapsules with Stimuli-Regulated Propulsion Open
One of the dreams of nanotechnology is to create tiny objects, nanobots, that are able to perform difficult tasks in dimensions and locations that are not directly accessible. One basic function of these nanobots is motility. Movements cre…
View article: Flow‐Induced Long‐Term Stable Slippery Surfaces
Flow‐Induced Long‐Term Stable Slippery Surfaces Open
Slippery lubricant‐infused surfaces allow easy removal of liquid droplets on surfaces. They consist of textured or porous substrates infiltrated with a chemically compatible lubricant. Capillary forces help to keep the lubricant in place. …
View article: Visible light active nanofibrous membrane for antibacterial wound dressing
Visible light active nanofibrous membrane for antibacterial wound dressing Open
Hydrogel nanofibrous membranes that show visible light-induced disinfection are developed for wound dressing application.
View article: Polymer brush functionalized SiO<sub>2</sub> nanoparticle based Nafion nanocomposites: a novel avenue to low-humidity proton conducting membranes
Polymer brush functionalized SiO<sub>2</sub> nanoparticle based Nafion nanocomposites: a novel avenue to low-humidity proton conducting membranes Open
Polymer brush grafted SiO2 NPs provide Nafion nanocomposite membranes with superior proton conductivities at ambient and moderately high temperatures over the entire range of relative humidity.
View article: Amino acid-based poly(ester amide) nanofibers for tailored enzymatic degradation prepared by miniemulsion-electrospinning
Amino acid-based poly(ester amide) nanofibers for tailored enzymatic degradation prepared by miniemulsion-electrospinning Open
Novel enzyme loaded scaffolds with enzyme-responsive degradable properties for drug delivery are prepared by an original inverse-miniemulsion electrospinning method.
View article: Dual-compartment nanofibres: separation of two highly reactive components in close vicinity
Dual-compartment nanofibres: separation of two highly reactive components in close vicinity Open
Nanofibers based on polyvinyl alcohol encapsulating epoxy and amine colloids in close vicinity as reactive compartments are investigated. Their crosslinking can be initiated upon thermal or mechanical stimuli and enables self-healing appli…