Anke Leichtle
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View article: Neural alpha oscillations and auditory steady-state responses during adaptation to a cochlear implant
Neural alpha oscillations and auditory steady-state responses during adaptation to a cochlear implant Open
The human auditory system must distinguish relevant sounds from noise. Severe hearing loss can be treated with cochlear implants (CIs), but how the brain adapts to electrical hearing remains unclear. This study examined adaptation to unila…
View article: Differential influence of 1,8-Cineol on distinct hypoxia-related immune alterations in human monocytes
Differential influence of 1,8-Cineol on distinct hypoxia-related immune alterations in human monocytes Open
View article: Neural Alpha Oscillations and Auditory Steady State Responses During Adaptation to a Cochlear Implant
Neural Alpha Oscillations and Auditory Steady State Responses During Adaptation to a Cochlear Implant Open
The human auditory system must distinguish relevant sounds from noise. Severe hearing loss can be treated with cochlear implants (CIs), but how the brain adapts to electrical hearing remains unclear. This study examined adaptation to unila…
View article: Gut microbial communities in chronic rhinosinusitis patients in response to 1,8-Cineol treatment
Gut microbial communities in chronic rhinosinusitis patients in response to 1,8-Cineol treatment Open
View article: Anti-inflammatory response to 1,8-Cineol and associated microbial communities in Otitis media patients
Anti-inflammatory response to 1,8-Cineol and associated microbial communities in Otitis media patients Open
View article: Partial recovery of peripheral blood monocyte subsets in head and neck squamous cell carcinoma patients upon radio(chemo)therapy is associated with decreased plasma CXCL11
Partial recovery of peripheral blood monocyte subsets in head and neck squamous cell carcinoma patients upon radio(chemo)therapy is associated with decreased plasma CXCL11 Open
Background Head and neck squamous cell carcinoma (HNSCC) represents a common and heterogeneous malignancy of the oral cavity, pharynx and larynx. Surgery and radio(chemo)therapy are the standard treatment options and also have great influe…
View article: 1,8-Cineol Attenuates Checkpoint Molecule PDL-1 and Adhesion Molecule CX3CR1 in Circulating Monocytes in Otitis Media Patients
1,8-Cineol Attenuates Checkpoint Molecule PDL-1 and Adhesion Molecule CX3CR1 in Circulating Monocytes in Otitis Media Patients Open
Background: Peripheral blood monocytes can be subdivided into different subsets based on the CD14/CD16 surface characteristics. Monocytes are a major source of cytokine secretion of pro-inflammatory immune responses, whereas CD16+ monocyte…
View article: Immunomodulatory Response of the Middle Ear Epithelial Cells in Otitis Media
Immunomodulatory Response of the Middle Ear Epithelial Cells in Otitis Media Open
Hypothesis The middle ear (ME) epithelium transforms because of changed immunomodulation during infection. Introduction The epithelial cells of the tympanic cavity represent the first line of defense in the context of otitis media. They ca…
View article: The Merits of Bilateral Application of Middle Ear Implants in Patients With Bilateral Conductive and/or Mixed Hearing Loss
The Merits of Bilateral Application of Middle Ear Implants in Patients With Bilateral Conductive and/or Mixed Hearing Loss Open
This study investigated sound localization abilities in patients with bilateral conductive and/or mixed hearing loss (BCHL) when listening with either one or two middle ear implants (MEIs). Sound localization was measured by asking patient…
View article: PANEL 3: Otitis media animal models, cell culture, tissue regeneration & pathophysiology
PANEL 3: Otitis media animal models, cell culture, tissue regeneration & pathophysiology Open
In conclusion, ex vivo and in vivo OM research models have seen great advancements in the past 4 years. From the usage of novel genetic and molecular tools to the refinement of in vivo inducible and spontaneous mouse models, to the introdu…
View article: Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers
Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers Open
(1) Background: to report on the use of high-dose-rate (HDR) interventional radiotherapy (brachytherapy, IRT) as a salvage treatment for patients with regionally relapsed head and neck cancers. (2) Methods: A retrospective study of 60 pati…
View article: Modes of Action of 1,8-Cineol in Infections and Inflammation
Modes of Action of 1,8-Cineol in Infections and Inflammation Open
The monoterpene 1,8-Cineol is a natural plant-based therapeutic agent that is commonly applied to treat different inflammatory diseases due to its mucolytic, anti-microbial and anti-inflammatory properties. It has become increasingly clear…
View article: Dynamic Microscopic Optical Coherence Tomography as a New Diagnostic Tool for Otitis Media
Dynamic Microscopic Optical Coherence Tomography as a New Diagnostic Tool for Otitis Media Open
Hypothesis: Otitis media (OM) can be successfully visualized and diagnosed by dynamic microscopic optical coherence tomography (dmOCT). Background: OM is one of the most common infectious diseases and, according to the WHO, one of the lead…
View article: TRIM21 Expression as a Prognostic Biomarker for Progression-Free Survival in HNSCC
TRIM21 Expression as a Prognostic Biomarker for Progression-Free Survival in HNSCC Open
Patients with head and neck squamous cell carcinoma (HNSCC) continue to have a rather poor prognosis. Treatment-related comorbidities have negative impacts on their quality of life. TRIM21 is a cytosolic E3 ubiquitin ligase that was initia…
View article: Determination of orally administered 1,8-Cineol in nasal polyp tissues from chronic rhinosinusitis patients using gas chromatography: mass spectrometry
Determination of orally administered 1,8-Cineol in nasal polyp tissues from chronic rhinosinusitis patients using gas chromatography: mass spectrometry Open
View article: Hearing rehabilitation and microbial shift after middle ear surgery with Vibrant Soundbridge in patients with chronic otitis media
Hearing rehabilitation and microbial shift after middle ear surgery with Vibrant Soundbridge in patients with chronic otitis media Open
Introduction Patients with otitis media (OM) encounter significant functional hearing impairment with conductive, or a combined hearing loss and long-term sequelae involving impaired speech/language development in children, reduced academi…
View article: Resolution of otitis media in a humanized mouse model
Resolution of otitis media in a humanized mouse model Open
Otitis media (OM) is one of the largest public health problems of children and has devastating impacts in developing countries. The substantial medical and human costs involved have led to research to understand the disease and improve tre…
View article: Einfluss von Richtmikrofonie auf die Höranstrengung bei Mittelohrimplantatträgern
Einfluss von Richtmikrofonie auf die Höranstrengung bei Mittelohrimplantatträgern Open
View article: Essential Role of the Innate Immune Adaptor RIP2 in the Response to Otitis Media
Essential Role of the Innate Immune Adaptor RIP2 in the Response to Otitis Media Open
Intracellular nucleotide binding and oligomerization domain (NOD) and Toll-like (TLR) receptors have emerged as pivotal sensors of infection. Both Nod1 and Nod2 contain a caspase activation and recruitment domain (CARD) that interacts with…
View article: Dynamic optical coherence tomography as a new diagnostic tool for otitis media
Dynamic optical coherence tomography as a new diagnostic tool for otitis media Open
Introduction The definitive therapy of therapy-refractory chronic otitis media mesotympanalis or epitympanalis (cholesteatoma) consists in the surgical resection of the inflammatory progress. Intraoperative diagnostics are limited to the v…
View article: Eine seltene Raumforderung der Tuba auditiva
Eine seltene Raumforderung der Tuba auditiva Open
Choristomatöse Heterotopien sind Versprengungen normaler Gewebszellen an für diese Zellen untypische Lokalisation.
View article: A Rare Tumor Of The Tuba Auditiva
A Rare Tumor Of The Tuba Auditiva Open
Choristoma or heterotopias are sprengths of normal tissue cells in aberrant locations.
View article: Dynamische optische Kohärenztomographie als neues Diagnoseverfahren für die Otitis media
Dynamische optische Kohärenztomographie als neues Diagnoseverfahren für die Otitis media Open
Einleitung Die definitive Therapie der therapierefraktären chronischen Otitis media mesotympanalis oder epitympanalis (Cholesteatom) besteht in der chirurgischen Sanierung des Entzündungsherdes. Die intraoperative Diagnostik ist dabei auf …
View article: Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways
Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways Open
In the imaging of airway tissue, optical coherence tomography (OCT) provides cross-sectional images of tissue structures, shows cilia movement and mucus secretion, but does not provide sufficient contrast to differentiate individual cells.…
View article: Immunomodulation as a Protective Strategy in Chronic Otitis Media
Immunomodulation as a Protective Strategy in Chronic Otitis Media Open
Introduction Major features of the pathogenesis in otitis media, the most common disease in childhood, include hyperplasia of the middle ear mucosa and infiltration by leukocytes, both of which typically resolve upon bacterial clearance vi…
View article: Dynamic microscopic optical coherence tomography to visualize morphological and functional micro-anatomy of the airways
Dynamic microscopic optical coherence tomography to visualize morphological and functional micro-anatomy of the airways Open
Imaging airway tissue, optical coherence tomography (OCT) provides cross-sectional images of tissue structures, shows cilia movement and mucus secretion, but does not provide sufficient contrast to differentiate individual cells. By using …
View article: Prognostic Factors for Complete Recovery From Xerostomia After Radiotherapy of Head-and-Neck Cancers
Prognostic Factors for Complete Recovery From Xerostomia After Radiotherapy of Head-and-Neck Cancers Open
Almost every fifth patient experienced complete recovery of xerostomia. Prognostic factors were identified that can guide radiation oncologists during the process of treatment planning.
View article: A Screen of Autophagy Compounds Implicates the Proteasome in Mammalian Aminoglycoside-Induced Hair Cell Damage
A Screen of Autophagy Compounds Implicates the Proteasome in Mammalian Aminoglycoside-Induced Hair Cell Damage Open
Introduction: Autophagy is a degradative pathway to safely break down and recycle dysfunctional cellular components. There is prior evidence of autophagy participation during hair cell (HC) damage. Our goal was to screen compounds targetin…
View article: Balloon eustachian tuboplasty (BET) in children with general or localized retractions of the tympanic membrane: subgroup analysis of a retrospective multicenter study
Balloon eustachian tuboplasty (BET) in children with general or localized retractions of the tympanic membrane: subgroup analysis of a retrospective multicenter study Open
Introduction General or localized retractions of the tympanic membrane are frequently seen in children. They pose a challenge to therapeutic decision making. On the one hand a significant proportion of retractions lingers stable. On the ot…
View article: Die Ballondilatation der Tuba Eustachii (BET) in der Therapie von Kindern mit Trommelfellretraktionen: Subgruppenanalyse einer retrospektiven Multicenter-Studie
Die Ballondilatation der Tuba Eustachii (BET) in der Therapie von Kindern mit Trommelfellretraktionen: Subgruppenanalyse einer retrospektiven Multicenter-Studie Open
Einleitung Generalisierte und lokalisierte Retraktionen des Trommelfells werden bei Kindern häufig gesehen, und stellen eine Herausforderung für die Therapieentscheidung dar. Einerseits bleibt ein signifikanter Anteil der Retraktionen lang…