Anke M. Tukker
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View article: Neuronal subtype-specific metabolic changes in neurodegenerative and neuropsychiatric diseases predicted via a systems biology-based approach
Neuronal subtype-specific metabolic changes in neurodegenerative and neuropsychiatric diseases predicted via a systems biology-based approach Open
Understanding how distinct neuronal subtypes contribute to Alzheimer’s disease (AD) pathology remains a major challenge. Patient-derived induced pluripotent stem cell (iPSC) studies have shown neuronal subtype-specific molecular and pathol…
View article: From Correlation to Causation: Cell-Type-Specific Gene Regulatory Networks in Alzheimer’s Disease
From Correlation to Causation: Cell-Type-Specific Gene Regulatory Networks in Alzheimer’s Disease Open
INTRODUCTION Alzheimer’s disease (AD) involves complex regulatory disruptions across multiple brain cell types, yet a comprehensive understanding of the intracellular causal mechanisms remains unclear. METHODS We presented an integrative a…
View article: Application of single cell gene expression technologies to neurotoxicology
Application of single cell gene expression technologies to neurotoxicology Open
View article: Mixture effects of tetrodotoxin (TTX) and drugs targeting voltage-gated sodium channels on spontaneous neuronal activity in vitro
Mixture effects of tetrodotoxin (TTX) and drugs targeting voltage-gated sodium channels on spontaneous neuronal activity in vitro Open
View article: Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant
Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant Open
With the wide adoption of genomic sequencing in children having seizures, an increasing number of SCN2A genetic variants have been revealed as genetic causes of epilepsy. Voltage-gated sodium channel Nav1.2, encoded by gene SCN2A , is pred…
View article: Single cell RNA sequencing detects persistent cell type- and methylmercury exposure paradigm-specific effects in a human cortical neurodevelopmental model
Single cell RNA sequencing detects persistent cell type- and methylmercury exposure paradigm-specific effects in a human cortical neurodevelopmental model Open
View article: The Impact of Environmental Factors on Monogenic Mendelian Diseases
The Impact of Environmental Factors on Monogenic Mendelian Diseases Open
Environmental factors and gene-environment interactions modify the variable expressivity, progression, severity, and onset of some classic (monogenic) Mendelian-inherited genetic diseases. Cystic fibrosis, Huntington disease, Parkinson’s d…
View article: Novel test strategies for in vitro seizure liability assessment
Novel test strategies for in vitro seizure liability assessment Open
Successful and cost-effective replacement of in vivo and ex vivo models for seizure liability screening can reduce animal use for drug development, while increasing the predictive value of the assays, particularly if human ce…
View article: Exciting Models
Exciting Models Open
Worldwide more and more people depend on medication for mental or neurodegenerative diseases, thereby increasing the demand for drugs affecting the central nervous system (CNS). Because these drugs have to cross the blood-brain-barrier, th…
View article: Applicability of hiPSC-Derived Neuronal Cocultures and Rodent Primary Cortical Cultures for In Vitro Seizure Liability Assessment
Applicability of hiPSC-Derived Neuronal Cocultures and Rodent Primary Cortical Cultures for In Vitro Seizure Liability Assessment Open
Seizures are life-threatening adverse drug reactions which are investigated late in drug development using rodent models. Consequently, if seizures are detected, a lot of time, money and animals have been used. Thus, there is a need for in…
View article: Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) acutely affect human α1β2γ2L GABAA receptor and spontaneous neuronal network function in vitro
Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) acutely affect human α1β2γ2L GABAA receptor and spontaneous neuronal network function in vitro Open
View article: Towards animal-free neurotoxicity screening: Applicability of hiPSC-derived neuronal models for in vitro seizure liability assessment
Towards animal-free neurotoxicity screening: Applicability of hiPSC-derived neuronal models for in vitro seizure liability assessment Open
A sizeable proportion of drug attrition is due to drug-induced seizures. Current available animal models frequently fail to predict human seizure liability. Therefore, there is a need for in vitro alternatives, preferably based on human-de…
View article: Towards animal-free neurotoxicity screening: Applicability of hiPSC-derived neuronal models for in vitro seizure liability assessment_suppl
Towards animal-free neurotoxicity screening: Applicability of hiPSC-derived neuronal models for in vitro seizure liability assessment_suppl Open
A sizeable proportion of drug attrition is due to drug-induced seizures. Currently available animal models frequently fail to predict human seizure liability. Therefore, there is a need for in vitro alternatives, preferably based on human-…
View article: Human iPSC-derived neuronal models for in vitro neurotoxicity assessment
Human iPSC-derived neuronal models for in vitro neurotoxicity assessment Open
View article: Solubility Constraints on Aquatic Ecotoxicity Testing of Anionic Surfactants
Solubility Constraints on Aquatic Ecotoxicity Testing of Anionic Surfactants Open
View article: Neuropharmacological characterization of the new psychoactive substance methoxetamine
Neuropharmacological characterization of the new psychoactive substance methoxetamine Open
The use of new psychoactive substances (NPS) is steadily increasing. One commonly used NPS is methoxetamine (MXE), a ketamine analogue. Several adverse effects have been reported following MXE exposure, while only limited data are availabl…
View article: Is the time right for in vitro neurotoxicity testing using human iPSC-derived neurons?
Is the time right for in vitro neurotoxicity testing using human iPSC-derived neurons? Open
Current neurotoxicity testing heavily relies on expensive, time consuming and ethically debated in vivo animal experiments that are unsuitable for screening large number of chemicals. Consequently, there is a clear need for (high-throughpu…