Anke Sambeth
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View article: Roflumilast and cognition enhancement: A translational perspective
Roflumilast and cognition enhancement: A translational perspective Open
Cognitive impairment affiliated with neurological disorders has a severe impact on daily life functioning and the quality of life of patients. This is associated with a significant and long-lasting health, social and financial burden, not …
View article: Triggers and conducive factors for reflection in university students: a focus group study
Triggers and conducive factors for reflection in university students: a focus group study Open
Although previous research highlights the importance of reflection in higher education, little is known about the type of triggers and contexts that promote authentic reflection in university students who are in academic classroom environm…
View article: Acute Treatment with the Nootropic CILTEP® Does Not Improve Cognitive Performance in Healthy Middle-Aged Participants
Acute Treatment with the Nootropic CILTEP® Does Not Improve Cognitive Performance in Healthy Middle-Aged Participants Open
This study investigated the acute effects of the dietary nootropic stack CILTEP®. It contains a combination of ingredients that have been individually reported to improve cognitive performance. Especially, the ingredients luteolin, which i…
View article: The potential cost‐effectiveness of roflumilast drug treatment in mild cognitive impairment
The potential cost‐effectiveness of roflumilast drug treatment in mild cognitive impairment Open
Background Evidence is needed on the value of new (pharmacological) health technologies in their early stage of development, to support stakeholders (industry, regulators, payers, and health care providers) in decision‐making linked to the…
View article: A mindful approach to controlling intrusive thoughts
A mindful approach to controlling intrusive thoughts Open
Intrusive thoughts of negative experiences can pose a threat to our well-being. To some extent, unwanted memories can be intentionally controlled via an executive control mechanism that downregulates the occurrence of intrusions. Mindfulne…
View article: The value of maintaining cognition in patients with mild cognitive impairment: The innovation headroom and potential cost‐effectiveness of roflumilast
The value of maintaining cognition in patients with mild cognitive impairment: The innovation headroom and potential cost‐effectiveness of roflumilast Open
INTRODUCTION Early health‐technology assessment can support discussing scarce resource allocation among stakeholders. We explored the value of maintaining cognition in patients with mild cognitive impairment (MCI) by estimating: (1) the in…
View article: Educational neuroscience: current status and future opportunities
Educational neuroscience: current status and future opportunities Open
Educational neuroscience explores the brain-behaviour relationship and in turn tries to link the relationships to developments in educational practice. This chapter introduces a number of methods that are common in educational neuroscience…
View article: Age Effects on Old/New Recognition Memory Involving Abstract Figures and Non-words
Age Effects on Old/New Recognition Memory Involving Abstract Figures and Non-words Open
Age-related memory problems posit a growing concern in our society. This study investigated the impact of age and memory strength on recognition memory of pre-experimentally unfamiliar abstract figures and non-words. We applied a three-pha…
View article: The antimuscarinic agent biperiden selectively impairs recognition of abstract figures without affecting the processing of non‐words
The antimuscarinic agent biperiden selectively impairs recognition of abstract figures without affecting the processing of non‐words Open
Objectives The present study investigated the effects of biperiden, a muscarinic type 1 antagonist, on the recognition performance of pre‐experimentally unfamiliar abstract figures and non‐words in healthy young volunteers. The aim was to …
View article: EEG Correlates of Old/New Discrimination Performance Involving Abstract Figures and Non-Words
EEG Correlates of Old/New Discrimination Performance Involving Abstract Figures and Non-Words Open
The processing of pre-experimentally unfamiliar stimuli such as abstract figures and non-words is poorly understood. Here, we considered the role of memory strength in the discrimination process of such stimuli using a three-phase old/new …
View article: Optimizing Behavioral Paradigms to Facilitate Development of New Treatments for Anhedonia and Reward Processing Deficits in Schizophrenia and Major Depressive Disorder: Study Protocol
Optimizing Behavioral Paradigms to Facilitate Development of New Treatments for Anhedonia and Reward Processing Deficits in Schizophrenia and Major Depressive Disorder: Study Protocol Open
Background: Behavioral tasks focusing on different subdomains of reward processing may provide more objective and quantifiable measures of anhedonia and impaired motivation compared with clinical scales. Typically, single tasks are used in…
View article: Biperiden Selectively Impairs Verbal Episodic Memory in a Dose- and Time-Dependent Manner in Healthy Subjects
Biperiden Selectively Impairs Verbal Episodic Memory in a Dose- and Time-Dependent Manner in Healthy Subjects Open
Purpose/Background Biperiden is a muscarinic antagonist that produces memory impairments without impairing attention or motor functions in healthy subjects. It has been suggested that a biperiden-induced memory deficit could model age- and…
View article: Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study
Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study Open
There is ample evidence that phosphodiesterase 4 (PDE4) inhibition can improve memory performance in animal studies. In the present study, we examined the acute effects of the PDE4 inhibitor roflumilast on memory performance in healthy ind…
View article: No interaction between rivastigmine and citalopram on memory and novelty processing in healthy human volunteers
No interaction between rivastigmine and citalopram on memory and novelty processing in healthy human volunteers Open
Background: Animal literature suggests an interaction between acetylcholine and serotonin on cognitive functions. Aims: The aim of the current study was to assess whether both neurotransmitters interact during memory and novelty processing…
View article: Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults
Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults Open
The need for new and effective treatments for dementia remains indisputably high. Phosphodiesterase inhibitors (PDE-Is) have proven efficacy as cognitive enhancers based on their positive effects in numerous preclinical studies. Especially…
View article: Acute administration of roflumilast enhances sensory gating in healthy young humans in a randomized trial
Acute administration of roflumilast enhances sensory gating in healthy young humans in a randomized trial Open
The PDE4 inhibitor roflumilast has a favorable side-effect profile at a cognitively effective dose and could be considered as a treatment in disorders affected by disrupted sensory gating.
View article: Why an M1 Antagonist Could Be a More Selective Model for Memory Impairment than Scopolamine
Why an M1 Antagonist Could Be a More Selective Model for Memory Impairment than Scopolamine Open
OPINION article Front. Neurol., 30 September 2016Sec. Neuropharmacology Volume 7 - 2016 | https://doi.org/10.3389/fneur.2016.00167
View article: Verbal Memory Impairment in Polydrug Ecstasy Users: A Clinical Perspective
Verbal Memory Impairment in Polydrug Ecstasy Users: A Clinical Perspective Open
The combination of the acute and long-term findings demonstrates that, while clinically relevant memory impairment is present during intoxication, it is absent during abstinence. This suggests that use of Ecstasy/MDMA does not lead to clin…
View article: Clinical relevance of verbal memory impairment in polydrug Ecstasy users: A pooled data analysis
Clinical relevance of verbal memory impairment in polydrug Ecstasy users: A pooled data analysis Open
Ecstasy, MDMA, memory impairment, verbal word learning test, clinical relevance
View article: Treatment of Cognitive Impairment in Schizophrenia: Potential Value of Phosphodiesterase Inhibitors in Prefrontal Dysfunction
Treatment of Cognitive Impairment in Schizophrenia: Potential Value of Phosphodiesterase Inhibitors in Prefrontal Dysfunction Open
No pharmacological treatment is available to date that shows satisfactory effects on cognitive symptoms in patients diagnosed with schizophrenia. Phosphodiesterase inhibitors (PDE-Is) improve neurotransmitter signaling by interfering in in…