Anke M. Smits
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View article: #2318 <b>A novel cardiovascular-kidney-metabolic syndrome mouse model with inducible HFrEF and atherosclerosis</b>
#2318 <b>A novel cardiovascular-kidney-metabolic syndrome mouse model with inducible HFrEF and atherosclerosis</b> Open
Background and Aims Cardiovascular damage is the major cause of death in chronic kidney disease (CKD). Our institute developed a diet-induced cardiovascular-kidney-metabolic (CKM) syndrome model including obesity, diabetes, hypertension, C…
View article: #2295 Characterization and standard of care efficacy testing in a translational mouse model of cardiovascular-kidney-metabolic syndrome
#2295 Characterization and standard of care efficacy testing in a translational mouse model of cardiovascular-kidney-metabolic syndrome Open
Background and Aims Cardiovascular-kidney-metabolic (CKM) syndrome is a multifactorial disease involving the interconnection of cardiovascular and kidney disease, obesity and type 2 diabetes which can exacerbate one another. To study the d…
View article: Preclinical extracellular matrix-based treatment strategies for myocardial infarction: a systematic review and meta-analysis
Preclinical extracellular matrix-based treatment strategies for myocardial infarction: a systematic review and meta-analysis Open
Background Administrating extracellular matrix (ECM) to restore cardiac function post-myocardial infarction (MI) shows promise, however study variability obscures its true impact. We therefore conducted a systematic review and meta-analysi…
View article: Cryopreservation of Human Adult Ventricular Tissue for the Preparation of Viable Myocardial Slices
Cryopreservation of Human Adult Ventricular Tissue for the Preparation of Viable Myocardial Slices Open
Living myocardial slices (LMS) are ultrathin sections of adult myocardium that can be maintained in culture. These slices provide a unique platform for studying interactions between cardiomyocytes (CMs), other cardiac cell types, and the e…
View article: Epicardial cell participation in cardiac repair requires epithelial-to-mesenchymal transition
Epicardial cell participation in cardiac repair requires epithelial-to-mesenchymal transition Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Dutch Heart Foundation During development, the epicardium forms as a single cell layer on the outside of the heart. Part of these cells undergo epithelia…
View article: #1311 Cardiac damage in a multifactorial DKD/CKD mouse model resembles HFpEF and can be reduced by standard-of-care treatment
#1311 Cardiac damage in a multifactorial DKD/CKD mouse model resembles HFpEF and can be reduced by standard-of-care treatment Open
Background and Aims We developed a diet-induced hypertension-accelerated mouse model of diabetic kidney disease characterized by progressive loss of GFR resulting in chronic kidney disease. Since cardiovascular disease is the major cause o…
View article: Single-cell RNA sequencing analysis of the human fetal epicardium reveals several new genes involved in regulation of epicardial activation
Single-cell RNA sequencing analysis of the human fetal epicardium reveals several new genes involved in regulation of epicardial activation Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Dutch Heart Foundation Background The outside mesothelial layer of the heart, the epicardium, is essential for cardiac development. Cells from this layer…
View article: Mutation in PDGFRbeta: a potential new pathogenic variant for acquired mitral valve prolapse
Mutation in PDGFRbeta: a potential new pathogenic variant for acquired mitral valve prolapse Open
Funding Acknowledgements None. Background Mitral valve prolapse (MVP) due to myxomatous degeneration is characterized by familial clustering, but few pathogenic genes have been identified. In a genetic screening program for MVP patients, w…
View article: Cryopreservation of human adult ventricular tissue for the preparation of viable myocardial slices
Cryopreservation of human adult ventricular tissue for the preparation of viable myocardial slices Open
Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): REGeRNA Myocardial slices are ultra-thin slices of living adult myocardium which can be cultured. As a multicellular 3-D culture model,…
View article: Cardiac delivery of modified mRNA using lipid nanoparticles: Cellular targets and biodistribution after intramyocardial administration
Cardiac delivery of modified mRNA using lipid nanoparticles: Cellular targets and biodistribution after intramyocardial administration Open
Despite research efforts being made towards preserving (or even regenerating) heart tissue after an ischemic event, there is a lack of resources in current clinical treatment modalities for patients with acute myocardial infarction that sp…
View article: Editorial: Novel strategies to repair the infarcted heart, volume II
Editorial: Novel strategies to repair the infarcted heart, volume II Open
EDITORIAL article Front. Cardiovasc. Med., 07 March 2024Sec. Cardiovascular Biologics and Regenerative Medicine Volume 11 - 2024 | https://doi.org/10.3389/fcvm.2024.1379240
View article: Abnormal preoperative haematological parameters in Endometrial cancer; reflecting tumour aggressiveness or reduced response to radiotherapy?
Abnormal preoperative haematological parameters in Endometrial cancer; reflecting tumour aggressiveness or reduced response to radiotherapy? Open
In endometrial cancer (EC), preoperative anaemia, thrombocytosis and leucocytosis appear to be associated with worse prognosis. It remains unclear whether these parameters solely reflect tumour aggressiveness, or also impact response to ad…
View article: Modeling cardiac injury using human cardiac slices to test therapeutic approaches for cardiac regeneration and repair
Modeling cardiac injury using human cardiac slices to test therapeutic approaches for cardiac regeneration and repair Open
Background Due to limited regenerative capacity of the adult human heart, myocardial infarction causes irreversible damage by inducing the death of cardiomyocytes and the formation of a fibrotic scar. These remodeling mechanisms cause loss…
View article: Single-cell RNA sequencing analysis of the human fetal epicardium results in novel epicardial-specific markers and reveals a role for CRIP1 in epicardial EMT
Single-cell RNA sequencing analysis of the human fetal epicardium results in novel epicardial-specific markers and reveals a role for CRIP1 in epicardial EMT Open
Background The outside mesothelial layer of the heart, the epicardium, is essential during cardiac development. Cells from this layer undergo epithelial-to-mesenchymal transition (EMT), migrate into the tissue and partake in cardiogenesis …
View article: The mesencephalic astrocyte-derived neurotrophic factor (MANF) as a novel regulator of post-infarction cardiac sympathetic hyperinnervation
The mesencephalic astrocyte-derived neurotrophic factor (MANF) as a novel regulator of post-infarction cardiac sympathetic hyperinnervation Open
Background Excessive outgrowth of sympathetic nerve fibers (sympathetic hyperinnervation) around the infarcted myocardium is associated with ventricular arrhythmia and an increased risk of sudden cardiac death. Post-infarction, epicardial …
View article: Editorial: Straight from the heart: Novel insights and future perspectives for cardiac repair
Editorial: Straight from the heart: Novel insights and future perspectives for cardiac repair Open
EDITORIAL article Front. Cardiovasc. Med., 14 February 2023Sec. Cardiovascular Biologics and Regenerative Medicine Volume 10 - 2023 | https://doi.org/10.3389/fcvm.2023.1149626
View article: Acute myocardial infarction induces remodeling of the murine superior cervical ganglia and the carotid body
Acute myocardial infarction induces remodeling of the murine superior cervical ganglia and the carotid body Open
A role for cardiac sympathetic hyperinnervation in arrhythmogenesis after myocardial infarction (MI) has increasingly been recognized. In humans and mice, the heart receives cervical as well as thoracic sympathetic contributions. In mice, …
View article: Activin A and ALK4 Identified as Novel Regulators of Epithelial to Mesenchymal Transition (EMT) in Human Epicardial Cells
Activin A and ALK4 Identified as Novel Regulators of Epithelial to Mesenchymal Transition (EMT) in Human Epicardial Cells Open
The epicardium, the mesothelial layer covering the heart, is a crucial cell source for cardiac development and repair. It provides cells and biochemical signals to the heart to facilitate vascularization and myocardial growth. An essential…
View article: Epicardial Contribution to the Developing and Injured Heart: Exploring the Cellular Composition of the Epicardium
Epicardial Contribution to the Developing and Injured Heart: Exploring the Cellular Composition of the Epicardium Open
The epicardium is an essential cell population during cardiac development. It contributes different cell types to the developing heart through epithelial-to-mesenchymal transition (EMT) and it secretes paracrine factors that support cardia…
View article: Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration
Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration Open
Fibroblasts are activated to repair the heart following injury. Fibroblast activation in the mammalian heart leads to a permanent fibrotic scar that impairs cardiac function. In other organisms, such as zebrafish, cardiac injury is followe…
View article: Generation, Characterization, and Application of Inducible Proliferative Adult Human Epicardium-Derived Cells
Generation, Characterization, and Application of Inducible Proliferative Adult Human Epicardium-Derived Cells Open
Rationale: In recent decades, the great potential of human epicardium-derived cells (EPDCs) as an endogenous cell source for cardiac regeneration has been recognized. The limited availability and low proliferation capacity of primary human…
View article: Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review
Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review Open
Molecular imaging of pathologic lesions can improve efficient detection of cancer and cardiovascular diseases. A shared pathophysiological feature is angiogenesis, the formation of new blood vessels. Endoglin (CD105) is a coreceptor for li…
View article: BMP Receptor Inhibition Enhances Tissue Repair in Endoglin Heterozygous Mice
BMP Receptor Inhibition Enhances Tissue Repair in Endoglin Heterozygous Mice Open
Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a severe vascular disorder caused by mutations in the TGFβ/BMP co-receptor endoglin. Endoglin haploinsufficiency results in vascular malformations and impaired neoangiogenesis. Further…
View article: Toward Biological Pacing by Cellular Delivery of Hcn2/SkM1
Toward Biological Pacing by Cellular Delivery of Hcn2/SkM1 Open
Electronic pacemakers still face major shortcomings that are largely intrinsic to their hardware-based design. Radical improvements can potentially be generated by gene or cell therapy-based biological pacemakers. Our previous work identif…
View article: Single-cell RNA sequencing of human fetal epicardium reveals novel markers and regulators of EMT
Single-cell RNA sequencing of human fetal epicardium reveals novel markers and regulators of EMT Open
Background The heart is covered by the epicardium, consisting of epithelial cells and a mesenchymal layer. The epicardium has been shown to be essential during cardiac development by contributing cells through epithelial-to-mesenchymal tra…