Ankit A. Desai
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View article: eNAMPT/TLR4 signaling drives PAH cellular phenotypic switching and lung vascular remodeling
eNAMPT/TLR4 signaling drives PAH cellular phenotypic switching and lung vascular remodeling Open
View article: Blood Pressure Effects and Risk of Hypotension due to Intravenous Furosemide in Acute Decompensated Heart Failure
Blood Pressure Effects and Risk of Hypotension due to Intravenous Furosemide in Acute Decompensated Heart Failure Open
Objective We quantified the magnitude of systolic blood pressure (SBP) adverse effects associated with intravenous furosemide (IVFu), compared to other factors, during treatment for acute decompensated heart failure (ADHF). Methods Continu…
View article: A STUDY OF ROLE OF INFERIOR TURBINECTOMY IN TUBOTYMPANIC EAR DISEASE.
A STUDY OF ROLE OF INFERIOR TURBINECTOMY IN TUBOTYMPANIC EAR DISEASE. Open
presents mostly with ear discharge and decreased hearing.It can be managed conservatively or with or without surgery. Objective: To study the role of inferior turbinectomy in tubotympanic ear disease. Materials and Methods: This prospectiv…
View article: A Peek into Pulmonary Hypertension through the Plasma Proteome
A Peek into Pulmonary Hypertension through the Plasma Proteome Open
View article: Cardiomyocyte-restricted MIAT deletion is sufficient to protect against murine myocardial infarction
Cardiomyocyte-restricted MIAT deletion is sufficient to protect against murine myocardial infarction Open
Myocardial infarction-associated transcript (MIAT), an intergenic long noncoding RNA (lncRNA), is conserved between rodents and humans and is directly linked to maladaptive cardiac remodeling in both patients and mouse models with various …
View article: Enhanced Spatial Transcriptomics Analysis of Mouse Lung Tissues Reveals Cell-Specific Gene Expression Changes Associated with Pulmonary Hypertension
Enhanced Spatial Transcriptomics Analysis of Mouse Lung Tissues Reveals Cell-Specific Gene Expression Changes Associated with Pulmonary Hypertension Open
Spatial transcriptomics technologies have emerged as powerful tools for understanding cellular identity and function within the natural spatial context of tissues. Traditional transcriptomics techniques, such as bulk and single-cell RNA se…
View article: Disparities in Clinical Outcomes Observed Within Electronic Health Record Data From a Statewide Cohort of Pulmonary Arterial Hypertension Patients
Disparities in Clinical Outcomes Observed Within Electronic Health Record Data From a Statewide Cohort of Pulmonary Arterial Hypertension Patients Open
Health disparities in patients with pulmonary arterial hypertension (PAH) have not been extensively reported in the United States. The aim of this project was to characterize the extent of demographic and socioeconomic disparities in clini…
View article: Transcriptomic profiling highlights cell proliferation in the progression of experimental pulmonary hypertension in rats
Transcriptomic profiling highlights cell proliferation in the progression of experimental pulmonary hypertension in rats Open
View article: Plasma Proteomics Identifies B2M as a Regulator of Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction
Plasma Proteomics Identifies B2M as a Regulator of Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction Open
BACKGROUND: Pulmonary hypertension (PH) represents an important phenotype in heart failure with preserved ejection fraction (HFpEF). However, management of PH-HFpEF is challenging because mechanisms involved in the regulation of PH-HFpEF r…
View article: Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension
Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension Open
BACKGROUND: The ubiquitin-proteasome system regulates protein degradation and the development of pulmonary arterial hypertension (PAH), but knowledge about the role of deubiquitinating enzymes in this process is limited. UCHL1 (ubiquitin c…
View article: Association of Male Sex With Worse Right Ventricular Function and Survival in Pulmonary Hypertension in the Redefining Pulmonary Hypertension Through Pulmonary Vascular Disease Phenomics Cohort
Association of Male Sex With Worse Right Ventricular Function and Survival in Pulmonary Hypertension in the Redefining Pulmonary Hypertension Through Pulmonary Vascular Disease Phenomics Cohort Open
In patients with PH in the PVDOMICS study, female sex was more common, whereas male sex was associated with worse RV function and decreased transplant-free survival, most notably at mild to moderate elevation of PVR.
View article: Genetic regulation and targeted reversal of lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension
Genetic regulation and targeted reversal of lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension Open
Vascular inflammation critically regulates endothelial cell (EC) pathophenotypes, particularly in pulmonary arterial hypertension (PAH). Dysregulation of lysosomal activity and cholesterol metabolism have known inflammatory roles in diseas…
View article: Pulmonary primary oxysterol and bile acid synthesis as a predictor of outcomes in pulmonary arterial hypertension
Pulmonary primary oxysterol and bile acid synthesis as a predictor of outcomes in pulmonary arterial hypertension Open
Pulmonary arterial hypertension (PAH) is a rare and fatal vascular disease with heterogeneous clinical manifestations. To date, molecular determinants underlying the development of PAH and related outcomes remain poorly understood. Herein,…
View article: Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension
Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension Open
Hypoxic reprogramming of vasculature relies on genetic, epigenetic, and metabolic circuitry, but the control points are unknown. In pulmonary arterial hypertension (PAH), a disease driven by hypoxia inducible factor (HIF)–dependent vascula…
View article: Sleep-Related Hypoxia, Right Ventricular Dysfunction, and Survival in Patients With Group 1 Pulmonary Arterial Hypertension
Sleep-Related Hypoxia, Right Ventricular Dysfunction, and Survival in Patients With Group 1 Pulmonary Arterial Hypertension Open
View article: Differential drug response in pulmonary arterial hypertension: The potential for precision medicine
Differential drug response in pulmonary arterial hypertension: The potential for precision medicine Open
Pulmonary arterial hypertension (PAH) is a rare, complex, and deadly cardiopulmonary disease. It is characterized by changes in endothelial cell function and smooth muscle cell proliferation in the pulmonary arteries, causing persistent va…
View article: Optimal computed tomography-based biomarkers for prediction of incisional hernia formation
Optimal computed tomography-based biomarkers for prediction of incisional hernia formation Open
View article: The prognostic value of improving congestion on lung ultrasound during treatment for acute heart failure differs based on patient characteristics at admission
The prognostic value of improving congestion on lung ultrasound during treatment for acute heart failure differs based on patient characteristics at admission Open
View article: Ventricular arrhythmias in sickle cell anemia
Ventricular arrhythmias in sickle cell anemia Open
View article: Defining the clinical validity of genes reported to cause pulmonary arterial hypertension
Defining the clinical validity of genes reported to cause pulmonary arterial hypertension Open
View article: Frequency of acute vasodilator response (AVR) in incident and prevalent patients with pulmonary arterial hypertension: Results from the pulmonary vascular disease phenomics study
Frequency of acute vasodilator response (AVR) in incident and prevalent patients with pulmonary arterial hypertension: Results from the pulmonary vascular disease phenomics study Open
The prevalence of acute vasodilator response (AVR) to inhaled nitric oxide (iNO) during right heart catheterization (RHC) is 12% in idiopathic pulmonary arterial hypertension (IPAH). AVR, however, is reportedly lower in other disease‐assoc…
View article: <i>RASA3</i> is a candidate gene in sickle cell disease‐associated pulmonary hypertension and pulmonary arterial hypertension
<i>RASA3</i> is a candidate gene in sickle cell disease‐associated pulmonary hypertension and pulmonary arterial hypertension Open
Pulmonary hypertension (PH) is associated with significant morbidity and mortality. RASA3 is a GTPase activating protein integral to angiogenesis and endothelial barrier function. In this study, we explore the association of RASA3 genetic …
View article: 25 In-hospital Change in Lung Ultrasound Congestion Score Predicts Heart Failure Rehospitalization and Death: Implications for Clinical Trials
25 In-hospital Change in Lung Ultrasound Congestion Score Predicts Heart Failure Rehospitalization and Death: Implications for Clinical Trials Open
OBJECTIVES/GOALS: Lung Ultrasound Congestion Score (LUS-CS) is a proposed measure for guiding treatment in acute heart failure (AHF). An emergency department (ED) pilot trial of LUS-guided diuresis showed reduced LUS-CS at 48 hours but no …
View article: Figure S6 from Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents
Figure S6 from Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents Open
Loss of PIM blunts hypoxia-induced stabilization of HIF-1/2 and the expression of HIF-1 target genes
View article: Figure S1 from Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents
Figure S1 from Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents Open
Treatment with anti-angiogenic agents increases CAIX expression
View article: Figure S2 from Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents
Figure S2 from Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents Open
PIM1 expressing tumors maintain vasculature during treatment with anti-angiogenic agents
View article: Data from Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents
Data from Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents Open
Purpose: Patients develop resistance to antiangiogenic drugs, secondary to changes in the tumor microenvironment, including hypoxia. PIM kinases are prosurvival kinases and their expression increases in hypoxia. The goal of this stu…
View article: Figure S4 from Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents
Figure S4 from Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents Open
Combinatorial inhibition of PIM and VEGF produces synergistic anti-tumor activity in xenograft models of prostate and colon cancer
View article: Figure S7 from Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents
Figure S7 from Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents Open
Simultaneous inhibition of PIM and VEGF reduces colon cancer metastasis
View article: Figure S4 from Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents
Figure S4 from Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents Open
Combinatorial inhibition of PIM and VEGF produces synergistic anti-tumor activity in xenograft models of prostate and colon cancer