Ankit Kumar Pathak
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View article: Whole Exome Sequencing in Healthy Individuals of Extreme Constitution Types Reveals Differential Disease Risk: A Novel Approach towards Predictive Medicine
Whole Exome Sequencing in Healthy Individuals of Extreme Constitution Types Reveals Differential Disease Risk: A Novel Approach towards Predictive Medicine Open
Precision medicine aims to move from traditional reactive medicine to a system where risk groups can be identified before the disease occurs. However, phenotypic heterogeneity amongst the diseased and healthy poses a major challenge for id…
View article: Spatio-temporal dynamics of intra-host variability in SARS-CoV-2 genomes
Spatio-temporal dynamics of intra-host variability in SARS-CoV-2 genomes Open
During the course of the COVID-19 pandemic, large-scale genome sequencing of SARS-CoV-2 has been useful in tracking its spread and in identifying variants of concern (VOC). Viral and host factors could contribute to variability within a ho…
A rigorous framework for detecting SARS-CoV-2 spike protein mutational ensemble from genomic and structural features Open
The recent release of SARS-CoV-2 genomic data from several countries has provided clues into the potential antigenic drift of the coronavirus population. In particular, the genomic instability observed in the spike protein necessitates imm…
A rigorous framework for detecting SARS-CoV-2 spike protein mutational ensemble from genomic and structural features Open
The recent release of SARS-CoV-2 genomic data from several countries has provided clues into the potential antigenic drift of the coronavirus population. In particular, the genomic instability observed in the spike protein necessitates imm…
View article: Spatio-temporal dynamics of intra-host variability in SARS-CoV-2 genomes
Spatio-temporal dynamics of intra-host variability in SARS-CoV-2 genomes Open
During the course of the COVID-19 pandemic, large-scale genome sequencing of SARS-CoV-2 has been useful in tracking its spread and in identifying Variants Of Concern (VOC). Besides, viral and host factors could contribute to variability wi…
Human<i>PRE-PIK3C2B</i>exhibits long-range intra- and inter-chromosomal interactions with genomic regions enriched in repressive marks Open
Human PRE-PIK3C2B is a dual nature polycomb response element that interacts with both polycomb as well as trithorax members. In the current study, using 4C-Seq ( C apturing C ircular C hromosomal C onformation- Seq uencing), we identified …
Invariant Genes in Human Genomes Open
With large-scale human genome and exome sequencing, a lot of focus has gone in studying variations present in genomes and their associations to various diseases. Since major emphasis has been put on their variations, less focus has been gi…
Multi-scale analysis of schizophrenia risk loci: Integrating centenarian genomes and spatio-temporal expression profiles suggests the need for adjunctive therapeutic interventions for neuropsychiatric disorders Open
Schizophrenia (SZ) is a debilitating mental illness with multigenic etiology and significant heritability. Despite extensive genetic studies the molecular etiology has remained enigmatic. A recent systems biology study suggested a protein-…