Ankita Sarkar
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View article: Protocol for a two-clone system to study signaling interactions among neuronal cells in a pre-clinical Alzheimer’s disease model
Protocol for a two-clone system to study signaling interactions among neuronal cells in a pre-clinical Alzheimer’s disease model Open
This protocol outlines a two-clone genetic mosaic approach in Drosophila to study cell signaling using the FLP/FRT (Flippase/Flippase recombination target) and Gal4/UAS (upstream activating sequence)/Gal80 systems. We generated a stable tr…
View article: Phagocytosis-driven neurodegeneration through opposing roles of an ABC transporter in neurons and phagocytes
Phagocytosis-driven neurodegeneration through opposing roles of an ABC transporter in neurons and phagocytes Open
Lipid homeostasis is critical to neuronal survival. ATP-binding cassette A (ABCA) proteins are lipid transporters associated with neurodegenerative diseases. How ABCA transporters regulate lipid homeostasis in neurodegeneration is an outst…
View article: SARS-CoV-2 persistence: A potential catalyst for age-associated neurodegenerative diseases
SARS-CoV-2 persistence: A potential catalyst for age-associated neurodegenerative diseases Open
The persistence of RNA viruses in the brain is increasingly recognized as a significant factor in the progression of age-related neurodegenerative diseases. This phenomenon is particularly evident in infections caused by various neurotropi…
View article: Phagocytosis-driven neurodegeneration through opposing roles of an ABC transporter in neurons and phagocytes
Phagocytosis-driven neurodegeneration through opposing roles of an ABC transporter in neurons and phagocytes Open
SUMMARY Lipid homeostasis is critical to the survival of neurons. Lipid transporters from the ATP-binding cassette A (ABCA) subfamily are important regulators of lipid trafficking and are associated with multiple neurodegenerative diseases…
View article: Evaluation of Trichoderma spp. as a plant growth promoter and antagonist of major pulse pathogens
Evaluation of Trichoderma spp. as a plant growth promoter and antagonist of major pulse pathogens Open
Trichoderma spp. is mostly used for the management of soil-borne diseases and some foliage and fruit diseases in a variety of crop plants. It can help the environment by reducing agrochemical pollution, promoting plant growth, and enhancin…
View article: miR-277 targets the proapoptotic gene-hid to ameliorate Aβ42-mediated neurodegeneration in Alzheimer’s model
miR-277 targets the proapoptotic gene-hid to ameliorate Aβ42-mediated neurodegeneration in Alzheimer’s model Open
View article: Cationic dextrin nanoparticles for effective intracellular delivery of cytochrome <i>C</i> in cancer therapy
Cationic dextrin nanoparticles for effective intracellular delivery of cytochrome <i>C</i> in cancer therapy Open
Intracellular protein delivery using cationic dextrin nanoparticles show promise as a selective and specific approach to cancer therapy.
View article: Microbial Exudates as Biostimulants: Role in Plant Growth Promotion and Stress Mitigation
Microbial Exudates as Biostimulants: Role in Plant Growth Promotion and Stress Mitigation Open
Microbes hold immense potential, based on the fact that they are widely acknowledged for their role in mitigating the detrimental impacts of chemical fertilizers and pesticides, which were extensively employed during the Green Revolution e…
View article: Butyrate limits inflammatory macrophage niche in NASH
Butyrate limits inflammatory macrophage niche in NASH Open
View article: Nanotechnology Toolkit for Combating COVID‐19 and Beyond
Nanotechnology Toolkit for Combating COVID‐19 and Beyond Open
The outbreak of SARS‐CoV‐2 is unlikely to be contained anytime soon with conventional medical technology. This beckons an urgent demand for novel and innovative interventions in clinical protocols, diagnostics, and therapeutics; to manage …
View article: Phagocytosis and self-destruction break down dendrites of <i>Drosophila</i> sensory neurons at distinct steps of Wallerian degeneration
Phagocytosis and self-destruction break down dendrites of <i>Drosophila</i> sensory neurons at distinct steps of Wallerian degeneration Open
Significance Mutations in the nicotinamide adenine dinucleotide (NAD + ) biosynthesis pathway are associated with progressive neurodegeneration; neuronal injury causes rapid breakdown of damaged axons and dendrites. NAD + reduction is thou…
View article: The curious case of SARM1: Dr. Jekyll and Mr. Hyde in cell death and immunity?
The curious case of SARM1: Dr. Jekyll and Mr. Hyde in cell death and immunity? Open
Sterile alpha and toll/interleukin‐1 receptor motif‐containing protein 1 (SARM1) was first identified as a novel ortholog of Drosophila protein CG7915 and was subsequently placed as the fifth member of the human TIR‐containing adaptor prot…
View article: Early loss of endogenous NAD<sup>+</sup> following rotenone treatment leads to Sarm1 activation that is ameliorated by PARP inhibition
Early loss of endogenous NAD<sup>+</sup> following rotenone treatment leads to Sarm1 activation that is ameliorated by PARP inhibition Open
Sarm1 is an evolutionary conserved innate immune adaptor protein that has emerged as a primary regulator of programmed axonal degeneration over the past decade. In vitro structural insights have revealed that although Sarm1 induces energy …
View article: Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARγ binodal complementary modules
Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARγ binodal complementary modules Open
View article: Versatile CRISPR/Cas9-mediated mosaic analysis by gRNA-induced crossing-over for unmodified genomes
Versatile CRISPR/Cas9-mediated mosaic analysis by gRNA-induced crossing-over for unmodified genomes Open
Mosaic animals have provided the platform for many fundamental discoveries in developmental biology, cell biology, and other fields. Techniques to produce mosaic animals by mitotic recombination have been extensively developed in Drosophil…
View article: A Two-Clone Approach to Study Signaling Interactions among Neuronal Cells in a Pre-clinical Alzheimer's Disease Model
A Two-Clone Approach to Study Signaling Interactions among Neuronal Cells in a Pre-clinical Alzheimer's Disease Model Open
View article: MAGIC: Mosaic Analysis by gRNA-Induced Crossing-over
MAGIC: Mosaic Analysis by gRNA-Induced Crossing-over Open
Mosaic animals have provided the platform for many fundamental discoveries in developmental biology, cell biology, and other fields. Techniques to produce mosaic animals by mitotic recombination have been extensively developed in Drosophil…
View article: Phagocytosis and self-destruction execute dendrite degeneration of Drosophila sensory neurons at distinct levels of NAD+ reduction
Phagocytosis and self-destruction execute dendrite degeneration of Drosophila sensory neurons at distinct levels of NAD+ reduction Open
After injury, severed dendrites and axons expose the "eat-me" signal phosphatidylserine (PS) on their surface and degenerate by disassembly. While axon degeneration is controlled by a conserved "axon-death" pathway that is thought to activ…
View article: Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo
Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo Open
Amyotrophic Lateral Sclerosis (ALS), a late-onset neurodegenerative disorder characterized by the loss of motor neurons in the central nervous system, has no known cure to-date. Disease causing mutations in human Fused in Sarcoma (FUS) lea…
View article: Sarm1 induction and accompanying inflammatory response mediates age-dependent susceptibility to rotenone-induced neurotoxicity
Sarm1 induction and accompanying inflammatory response mediates age-dependent susceptibility to rotenone-induced neurotoxicity Open
Aging is a complex biological process and environmental risk factors like pesticide exposure have been implicated in the increased incidence of age-related neurodegenerative diseases like Parkinson’s disease (PD) but the etiology remains u…
View article: A soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye
A soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye Open
Alzheimer’s disease (AD), a fatal progressive neurodegenerative disorder, also results from accumulation of amyloid-beta 42 (Aβ42) plaques. These Aβ42 plaques trigger oxidative stress, abnormal signaling, which results in neuronal death by…
View article: Characterization of a morphogenetic furrow specific Gal4 driver in the developing Drosophila eye
Characterization of a morphogenetic furrow specific Gal4 driver in the developing Drosophila eye Open
The ability to express a gene of interest in a spatio-temporal manner using Gal4-UAS system has allowed the use of Drosophila model to study various biological phenomenon. During Drosophila eye development, a synchronous wave of differenti…
View article: Drosophila Eye Model to Study Neurodegeneration
Drosophila Eye Model to Study Neurodegeneration Open
View article: Cullin-4 regulates Wingless and JNK signaling-mediated cell death in the Drosophila eye
Cullin-4 regulates Wingless and JNK signaling-mediated cell death in the Drosophila eye Open
In all multicellular organisms, the fundamental processes of cell proliferation and cell death are crucial for growth regulation during organogenesis. Strict regulation of cell death is important to maintain tissue homeostasis by affecting…
View article: A potent betulinic acid analogue ascertains an antagonistic mechanism between autophagy and proteasomal degradation pathway in HT-29 cells
A potent betulinic acid analogue ascertains an antagonistic mechanism between autophagy and proteasomal degradation pathway in HT-29 cells Open
View article: Alzheimer′s disease: the silver tsunami of the 21<sup>st</sup>century
Alzheimer′s disease: the silver tsunami of the 21<sup>st</sup>century Open
Alzheimer's disease (AD), a fatal progressive neurodegenerative disorder, has no cure to date. One of the causes of AD is the accumulation of amyloid-beta 42 (Aβ42) plaques, which result in the onset of neurodegeneration. It is not known h…
View article: Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer’s Disease
Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer’s Disease Open
We have identified CBP as a genetic modifier of Aβ42 mediated neurodegeneration. Furthermore, we have identified BHQ domain of CBP is responsible for its neuroprotective function. These studies may have significant bearing on our understan…
View article: The Hippo pathway effector Yki downregulates Wg signaling to promote retinal differentiation in the <i>Drosophila</i> eye
The Hippo pathway effector Yki downregulates Wg signaling to promote retinal differentiation in the <i>Drosophila</i> eye Open
The evolutionarily conserved Hippo signaling pathway is known to regulate cell proliferation and maintain tissue homeostasis during development. We found that activation of Yorkie (Yki), the effector of the Hippo signaling pathway, causes …