An Chen
YOU?
Author Swipe
View article: Chimeras co-targeting antigens and FcγRIIb trigger degradation of extracellular soluble proteins and pathological aggregates
Chimeras co-targeting antigens and FcγRIIb trigger degradation of extracellular soluble proteins and pathological aggregates Open
While the clinical utility of conventional antibody therapies is undeniable, their therapeutic potential is often constrained high antigen loads and the recycling of antibody-antigen complexes via neonatal Fc receptor (FcRn). Here, we pres…
View article: Impact of Ultrasound-Guided Rectus Abdominis Sheath Block on Analgesia and Agitation During the Awakening Period in Children Undergoing Single-Incision Laparoscopic Inguinal Hernia Repair: A Randomized Clinical Trial
Impact of Ultrasound-Guided Rectus Abdominis Sheath Block on Analgesia and Agitation During the Awakening Period in Children Undergoing Single-Incision Laparoscopic Inguinal Hernia Repair: A Randomized Clinical Trial Open
Ultrasound-guided RSB is a safe and effective technique for postoperative analgesia in pediatric single-incision laparoscopic inguinal hernia repair. It provides superior pain relief, reduces EA incidence, and minimizes opioid use. These f…
View article: H-type double gallbladder malformation: a case report
H-type double gallbladder malformation: a case report Open
Biliary tract malformations are rare congenital anomalies, occurring in approximately 1 in 4000 individuals that may predispose to cholelithiasis and increase surgical risks, emphasizing the need for precise preoperative diagnosis. We repo…
View article: Clinical characteristics, echocardiographic findings, and computed tomography angiography in the diagnosis of sinus venosus atrial septal defect with partial anomalous pulmonary venous connection in 10 dogs
Clinical characteristics, echocardiographic findings, and computed tomography angiography in the diagnosis of sinus venosus atrial septal defect with partial anomalous pulmonary venous connection in 10 dogs Open
Sinus venosus atrial septal defect in dogs is often accompanied by PAPVC, which was present in 100% of the cases in this group of dogs. Computed tomography proved to be a valuable diagnostic tool, enhancing the sensitivity of identifying S…
View article: Traditional Chinese medicine in the treatment of breast Cancer
Traditional Chinese medicine in the treatment of breast Cancer Open
View article: Balancing Annuities and Tontines: A Study of Temporal Risk Aversion in Retirement Planning
Balancing Annuities and Tontines: A Study of Temporal Risk Aversion in Retirement Planning Open
View article: STING Facilitates Vascular Calcification via p‐STAT1/NLRP3 Signal
STING Facilitates Vascular Calcification via p‐STAT1/NLRP3 Signal Open
Vascular calcification is an independent predictor of cardiovascular mortality in patients with chronic kidney disease (CKD), yet no approved treatment exists. The cGAS‐STING signaling participates in various cardiovascular diseases. Notab…
View article: Thrombospondin‐1 binds to integrin β3 to inhibit vascular calcification through suppression of <scp>NF</scp>‐<scp>κB</scp> pathway
Thrombospondin‐1 binds to integrin β3 to inhibit vascular calcification through suppression of <span>NF</span>‐<span>κB</span> pathway Open
Vascular calcification is an important risk factor related to all‐cause mortality of cardiovascular events in patients with chronic kidney disease (CKD). Vascular extracellular matrix (ECM) proteins have been demonstrated to regulate vascu…
View article: Relationship between Street-View Green Space and School Myopia in Hubei Province: A Multi-Center Cross-Sectional Study
Relationship between Street-View Green Space and School Myopia in Hubei Province: A Multi-Center Cross-Sectional Study Open
View article: Mendelian randomization analysis reveals causal factors behind diabetic nephropathy: evidence, opportunities, and challenges
Mendelian randomization analysis reveals causal factors behind diabetic nephropathy: evidence, opportunities, and challenges Open
Diabetic nephropathy (DN), as the most serious minor vascular complication of diabetes, imposes a significant socioeconomic and medical cost around the world, and its prevention and treatment are a major challenge in the current medical co…
View article: Single-cell RNA-seq analysis revealed the stemness of a specific cluster of B cells in acute lymphoblastic leukemia progression
Single-cell RNA-seq analysis revealed the stemness of a specific cluster of B cells in acute lymphoblastic leukemia progression Open
Background Childhood acute lymphoblastic leukemia (ALL) is a common pediatric cancer. The heterogeneous characterization of B cells in ALL progression poses new challenges to researchers. We used single-cell sequencing to explore the criti…
View article: Deciphering the Mechanism of Siwu Decoction Inhibiting Liver Metastasis by Integrating Network Pharmacology and In Vivo Experimental Validation
Deciphering the Mechanism of Siwu Decoction Inhibiting Liver Metastasis by Integrating Network Pharmacology and In Vivo Experimental Validation Open
Background: Siwu Decoction (SWD) is a well-known classical TCM formula that has been shown to be effective as a basis for preventing and reducing liver metastases (LM). However, the active ingredients and potential molecular mechanisms rem…
View article: The role of alkyl chain length in the melt and solution crystallization of paliperidone aliphatic prodrugs
The role of alkyl chain length in the melt and solution crystallization of paliperidone aliphatic prodrugs Open
Fatty acid-derivative prodrugs have been utilized extensively to improve the physicochemical, biopharmaceutical and pharmacokinetic properties of active pharmaceutical ingredients. However, to our knowledge, the crystallization behavior of…
View article: Ultrasound-guided dexmedetomidine combination with modified high fascia iliaca compartment block for arthroscopic knee surgery: What is the Optimal Dose of Dexmedetomidine?
Ultrasound-guided dexmedetomidine combination with modified high fascia iliaca compartment block for arthroscopic knee surgery: What is the Optimal Dose of Dexmedetomidine? Open
Background: Total knee arthroplasty (TKA) is a common orthopedic procedure for end-stage knee osteoarthritis. Although effective in relieving pain and improving function, postoperative pain is still a common and distressing problem for man…
View article: Clinicopathological and prognostic significance of PD-L1 and TIM-3 expression in medullary thyroid carcinoma: a retrospective immunohistochemistry study
Clinicopathological and prognostic significance of PD-L1 and TIM-3 expression in medullary thyroid carcinoma: a retrospective immunohistochemistry study Open
View article: Comprehensive Analysis of Necroptosis Landscape in Skin Cutaneous Melanoma for Appealing its Implications in Prognosis Estimation and Microenvironment Status
Comprehensive Analysis of Necroptosis Landscape in Skin Cutaneous Melanoma for Appealing its Implications in Prognosis Estimation and Microenvironment Status Open
Purpose: Due to poor prognosis and immunotherapy failure of skin cutaneous melanoma (SKCM), this study sought to find necroptosis-related biomarkers to predict prognosis and improve the situation with predicted immunotherapy drugs. Experim…
View article: Exploring the Effects of Different Bci-Based Attention Training Games on the Brain: A Functional Near-Infrared Spectroscopy Study
Exploring the Effects of Different Bci-Based Attention Training Games on the Brain: A Functional Near-Infrared Spectroscopy Study Open
View article: SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR
SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR Open
View article: P300 Inhibition Improves Cell Apoptosis and Cognition Impairment Induced by Sevoflurane Through Regulating IL-17A Activation
P300 Inhibition Improves Cell Apoptosis and Cognition Impairment Induced by Sevoflurane Through Regulating IL-17A Activation Open
These data show that P300 will potentially be a new drug target for the therapy of cognition impairment caused by Sev.
View article: Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway
Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway Open
Vascular calcification is a common pathologic condition in patients with chronic kidney disease (CKD) and aging individuals. It has been established that vascular calcification is a gene‐regulated biological process resembling osteogenesis…
View article: Care-Dependent Tontines
Care-Dependent Tontines Open
View article: Norcantharidin regulates ERα signaling and tamoxifen resistance via targeting miR-873/CDK3 in breast cancer cells
Norcantharidin regulates ERα signaling and tamoxifen resistance via targeting miR-873/CDK3 in breast cancer cells Open
MiR-873/CDK3 has been shown to play a critical role in ERα signaling and tamoxifen resistance. Thus, targeting this pathway may be a potential therapeutic approach for the treatment of ER positive breast cancer especially tamoxifen resista…
View article: Pre-exposure to 50 Hz-electromagnetic fields enhanced the antiproliferative efficacy of 5-fluorouracil in breast cancer MCF-7 cells
Pre-exposure to 50 Hz-electromagnetic fields enhanced the antiproliferative efficacy of 5-fluorouracil in breast cancer MCF-7 cells Open
Resistance to 5-fluorouracil (5-FU) and its induced immune suppression have prevented its extensive application in the clinical treatment of breast cancer. In this study, the combined effect of 50 Hz-EMFs and 5-FU in the treatment of breas…
View article: Influence of antiviral therapy on survival of patients with hepatitis B-associated hepatocellular carcinoma undergoing transarterial chemoembolization
Influence of antiviral therapy on survival of patients with hepatitis B-associated hepatocellular carcinoma undergoing transarterial chemoembolization Open
Purpose: To examine the prognostic value of antiviral therapy among hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE).Method: A total of 356 patients with HCC undergoing TACE were recruited for the p…
View article: Downregulation of ATG5-dependent macroautophagy by chaperone-mediated autophagy promotes breast cancer cell metastasis
Downregulation of ATG5-dependent macroautophagy by chaperone-mediated autophagy promotes breast cancer cell metastasis Open
Recent data have shown that the expression of lysosome-associated membrane protein type 2 A (LAMP2A), the key protein in the chaperone-mediated autophagy (CMA) pathway, is elevated in breast tumor tissues. However, the exact effects and me…
View article: CADM1 regelates the G1/S transition and represses tumorigenicity through the Rb-E2F pathway in hepatocellular carcinoma
CADM1 regelates the G1/S transition and represses tumorigenicity through the Rb-E2F pathway in hepatocellular carcinoma Open
Our results showed that suppression of tumorigenesis by CADM1 may be mediated by the Rb-E2F pathway, involving upregulation of Rb protein levels. This pathway could therefore represent an attractive target for HCC therapy.
View article: FLIPL is critical for aerobic glycolysis in hepatocellular carcinoma
FLIPL is critical for aerobic glycolysis in hepatocellular carcinoma Open
Our results indicate that FLIPL plays an essential role in HCC aerobic glycolysis and that SGLT1 is required for FLIPL-modulated tumor proliferation under low glucose conditions. Targeting the actions of FLIPL in cell glucose-dependent aer…
View article: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids
Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids Open
The alteration of bile acids balance in colon cancers indicated the possibility of complicated diseases due to the disrupted balance of bile acids.
View article: Downregulation of microRNA-100 protects H2O2-induced apoptosis in neonatal cardiomyocytes.
Downregulation of microRNA-100 protects H2O2-induced apoptosis in neonatal cardiomyocytes. Open
Hypoxia or reoxygenation-induced cardiomyocyte apoptosis is one of the major causes of cardiac dysfunction. Recently, regulations of microRNAs were shown to play important roles in cardiomyocyte apoptosis. MicroRNA-100 (miR-100) is one of …