Anying Xiong
YOU?
Author Swipe
View article: Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing
Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing Open
Lung adenocarcinoma (LUAD) progression involves dynamic remodeling of the tumor microenvironment (TME). However, the stage‐specific dynamics of immune and stromal cell remodeling throughout LUAD progression remain incompletely understood. …
View article: Total Pore–Throat Size Distribution Characteristics and Oiliness Differences Analysis of Different Oil-Bearing Tight Sandstone Reservoirs—A Case Study of Chang6 Reservoir in Xiasiwan Oilfield, Ordos Basin
Total Pore–Throat Size Distribution Characteristics and Oiliness Differences Analysis of Different Oil-Bearing Tight Sandstone Reservoirs—A Case Study of Chang6 Reservoir in Xiasiwan Oilfield, Ordos Basin Open
In the observation of tight sandstone cores, the variations in the hydrocarbon charging usually can be observed in the same geological age reservoirs, which manifest as differential oil staining on the core surface. In order to clarify the…
View article: Sex-specific global burden of cardiometabolic and respiratory diseases attributable to secondhand smoke exposure: Insights from the global burden of disease study 2021
Sex-specific global burden of cardiometabolic and respiratory diseases attributable to secondhand smoke exposure: Insights from the global burden of disease study 2021 Open
Sex differences in SHS-attributable burden persist and vary by SDI; policy responses should be sex- and context-specific.
View article: METTL3-driven m6A modification orchestrates mitophagy-dependent ferroptosis in PM2.5-induced lung injury
METTL3-driven m6A modification orchestrates mitophagy-dependent ferroptosis in PM2.5-induced lung injury Open
Air pollution, particularly from fine particulate matter (PM2.5), poses a significant threat to respiratory health, yet the molecular mechanisms underlying PM2.5-induced lung injury remain incompletely understood. This study investigated t…
View article: Artificial Neural Networks-based production performance forecast for low permeability oil field
Artificial Neural Networks-based production performance forecast for low permeability oil field Open
View article: A Review of Jurassic Paleoclimatic Changes and Tectonic Evolution in the Qaidam Block, Northern Qinghai-Tibetan Plateau
A Review of Jurassic Paleoclimatic Changes and Tectonic Evolution in the Qaidam Block, Northern Qinghai-Tibetan Plateau Open
Understanding the mechanisms and speed of paleo-aridification in the Qaidam Block—driven by tectonic uplift and shifts in atmospheric circulation—provides critical long-term context for assessing modern climate variability and anthropogeni…
View article: Epithelial <i>Atg5</i> Deficiency Intensifies Caspase‐11 Activation, Fueling Extracellular mtDNA Release to Activate cGAS–STING–NLRP3 Axis in Macrophages During <i>Pseudomonas</i> Infection
Epithelial <i>Atg5</i> Deficiency Intensifies Caspase‐11 Activation, Fueling Extracellular mtDNA Release to Activate cGAS–STING–NLRP3 Axis in Macrophages During <i>Pseudomonas</i> Infection Open
Pseudomonas aeruginosa ( P. aeruginosa ) infections pose a significant threat to public health, underscoring the need for deeper insights into host cellular defenses. This study explores the critical role of autophagy‐related protein 5 (AT…
View article: Artificial Neural Networks-Based Production Performance Forecast for Low Permeability Oil Field
Artificial Neural Networks-Based Production Performance Forecast for Low Permeability Oil Field Open
View article: Candida albicans-Derived β-Glucan as a Novel Modulator of Tumor Microenvironment: Targeting Macrophage Polarization and Inducing Ferroptosis in Lung Cancer
Candida albicans-Derived β-Glucan as a Novel Modulator of Tumor Microenvironment: Targeting Macrophage Polarization and Inducing Ferroptosis in Lung Cancer Open
These results collectively provide novel insights into the immunotherapeutic potential of β-glucan from Candida albicans and its role in modulating TAM polarization and lung cancer growth, offering a promising avenue for cancer treatment s…
View article: Immunization with an adeno-associated viral vectored allergy vaccine containing Der p1-Der p2 effectively alleviates an asthmatic phenotype in mice
Immunization with an adeno-associated viral vectored allergy vaccine containing Der p1-Der p2 effectively alleviates an asthmatic phenotype in mice Open
Given the rising incidence of allergic asthma, current symptomatic treatments primarily offer relief rather than halt disease progression. Recombinant allergens, designed with reduced immunoglobulin E (IgE) reactivity and the ability to re…
View article: Deciphering the microbial landscape of lower respiratory tract infections: insights from metagenomics and machine learning
Deciphering the microbial landscape of lower respiratory tract infections: insights from metagenomics and machine learning Open
Background Lower respiratory tract infections represent prevalent ailments. Nonetheless, current comprehension of the microbial ecosystems within the lower respiratory tract remains incomplete and necessitates further comprehensive assessm…
View article: HO-1 upregulation promotes mitophagy-dependent ferroptosis in PM2.5-exposed hippocampal neurons
HO-1 upregulation promotes mitophagy-dependent ferroptosis in PM2.5-exposed hippocampal neurons Open
Fine particulate matter (PM2.5) has been extensively implicated in the pathogenesis of neurodevelopmental disorders, but the underlying mechanism remains unclear. Recent studies have revealed that PM2.5 plays a role in regulating iron meta…
View article: PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment
PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment Open
This comprehensive review explores the intricate mechanisms of PANoptosis and its implications in cancer. PANoptosis, a convergence of apoptosis, pyroptosis, and necroptosis, plays a crucial role in cell death and immune response regulatio…
View article: Fine particulate matter 2.5 induces susceptibility to Pseudomonas aeruginosa infection via expansion of PD-L1high neutrophils in mice
Fine particulate matter 2.5 induces susceptibility to Pseudomonas aeruginosa infection via expansion of PD-L1high neutrophils in mice Open
View article: Oxidative stress-mediated activation of FTO exacerbates impairment of the epithelial barrier by up-regulating IKBKB via N6-methyladenosine-dependent mRNA stability in asthmatic mice exposed to PM2.5
Oxidative stress-mediated activation of FTO exacerbates impairment of the epithelial barrier by up-regulating IKBKB via N6-methyladenosine-dependent mRNA stability in asthmatic mice exposed to PM2.5 Open
In order to comprehend the underlying mechanisms contributing to the development and exacerbation of asthma resulting from exposure to fine particulate matter (PM2.5), we established an asthmatic model in fat mass and obesity-associated ge…
View article: MMP14high macrophages orchestrate progressive pulmonary fibrosis in SR-Ag-induced hypersensitivity pneumonitis
MMP14high macrophages orchestrate progressive pulmonary fibrosis in SR-Ag-induced hypersensitivity pneumonitis Open
Fibrotic hypersensitivity pneumonitis (FHP) is a fatal interstitial pulmonary disease with limited treatment options. Lung macrophages are a heterogeneous cell population that exhibit distinct subsets with divergent functions, playing pivo…
View article: Integrated analysis of ATAC-seq and RNA-seq unveils the role of ferroptosis in PM2.5-induced asthma exacerbation
Integrated analysis of ATAC-seq and RNA-seq unveils the role of ferroptosis in PM2.5-induced asthma exacerbation Open
These findings shed light on the molecular mechanisms underlying PM2.5-induced asthma exacerbation, with epigenetic modifications playing a pivotal role. Furthermore, it suggests the therapeutic potential of targeting ferroptosis as an int…
View article: Single cell characteristics of patients with vaccine-related adverse reactions following inactivated COVID-19 vaccination
Single cell characteristics of patients with vaccine-related adverse reactions following inactivated COVID-19 vaccination Open
A good safety and immunogenicity profile was reported in Phase I and II clinical trials of inactivated SARS-CoV-2 vaccines. Here, we report two cases associated with vaccine-associated adverse events, including one patient with fever and a…
View article: Mitochondrial quality control in lung diseases: current research and future directions
Mitochondrial quality control in lung diseases: current research and future directions Open
Lung diseases are a major global health problem, affecting millions of people worldwide. Recent research has highlighted the critical role that mitochondrial quality control plays in respiratory-related diseases, including chronic obstruct…
View article: Neuritin affects the activity of neuralized-like 1 by promoting degradation and weakening its affinity for substrate
Neuritin affects the activity of neuralized-like 1 by promoting degradation and weakening its affinity for substrate Open
Neuritin plays a key role in neural development and regeneration by promoting neurite outgrowth and synapse maturation. Our previous research revealed the mechanism by which neuritin inhibits Notch signaling through interaction with neural…
View article: Transcriptome analysis identifies IL24 as an autophagy modulator in PM2.5 caused lung dysfunction
Transcriptome analysis identifies IL24 as an autophagy modulator in PM2.5 caused lung dysfunction Open
View article: Methyltransferase-like 3 leads to lung injury by up-regulation of interleukin 24 through N6-methyladenosine-dependent mRNA stability and translation efficiency in mice exposed to fine particulate matter 2.5
Methyltransferase-like 3 leads to lung injury by up-regulation of interleukin 24 through N6-methyladenosine-dependent mRNA stability and translation efficiency in mice exposed to fine particulate matter 2.5 Open
Fine particulate matter 2.5 (PM2.5) exposure leads to the progress of pulmonary disease. It has been reported that N6-methyladenosine (m6A) modification was involved in various biological processes and diseases. However, the critical role …
View article: Characterizing cellular heterogeneity in fibrotic hypersensitivity pneumonitis by single-cell transcriptional analysis
Characterizing cellular heterogeneity in fibrotic hypersensitivity pneumonitis by single-cell transcriptional analysis Open
Fibrotic hypersensitivity pneumonitis (FHP) remains one of fatal interstitial pulmonary disease. Comprehensively dissecting the cellular heterogeneity of FHP paves the way for developing general gene therapeutic solutions for FHP. Here, ut…
View article: Fine Particulate Matter Injury Airway Barrier Through Oxidative Stress Promotes the Demethylase <i>FTO</i> Regulating <i>IKKβ</i> m6A Modification and <i>NF-κB</i> Activation in Asthma
Fine Particulate Matter Injury Airway Barrier Through Oxidative Stress Promotes the Demethylase <i>FTO</i> Regulating <i>IKKβ</i> m6A Modification and <i>NF-κB</i> Activation in Asthma Open
View article: PM2.5 Aggravated OVA-Induced Epithelial Tight Junction Disruption Through Fas Associated via Death Domain-Dependent Apoptosis in Asthmatic Mice
PM2.5 Aggravated OVA-Induced Epithelial Tight Junction Disruption Through Fas Associated via Death Domain-Dependent Apoptosis in Asthmatic Mice Open
Taken together, we demonstrated that PM2.5 aggravated epithelial tight junction disruption through apoptosis mediated by up-regulation of FADD in OVA-induced model.
View article: Transcriptome-wide profiling discover: PM2.5 aggravates airway dysfunction through epithelial barrier damage regulated by Stanniocalcin 2 in an OVA-induced model
Transcriptome-wide profiling discover: PM2.5 aggravates airway dysfunction through epithelial barrier damage regulated by Stanniocalcin 2 in an OVA-induced model Open
View article: PM2.5 aggravates NQO1-induced mucus hyper-secretion through release of neutrophil extracellular traps in an asthma model
PM2.5 aggravates NQO1-induced mucus hyper-secretion through release of neutrophil extracellular traps in an asthma model Open
Taken together, we discovered a potential relationship between asthma severity and PM2.5 exposure. In addition, neutrophil depletion, NETs inhibition or anti-NQO1 might be novel potential therapeutic options for treatment of PM2.5-induced …
View article: Virtual Screening of Potential AEC2 Inhibitors for COVID-19 from Traditional Chinese Medicine
Virtual Screening of Potential AEC2 Inhibitors for COVID-19 from Traditional Chinese Medicine Open
Background: Angiotensin-converting enzyme 2 (ACE2), a negative regulator of the renin-angiotensin system and the severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-CoV-2 receptor, plays an important role in viral genome repl…
View article: An Integrative Analysis Identifying Transcriptional Features and key Genes Involved in COVID-19
An Integrative Analysis Identifying Transcriptional Features and key Genes Involved in COVID-19 Open
Aim: To elucidate the transcriptional characteristics of COVID-19. Materials & methods: We utilized an integrative approach to comprehensively analyze the transcriptional features of both COVID-19 patients and SARS-CoV-2 infe…
View article: Integrative Bioinformatics Analysis Provides Insight into the Molecular Mechanisms of 2019-nCoV
Integrative Bioinformatics Analysis Provides Insight into the Molecular Mechanisms of 2019-nCoV Open
The 2019-nCoV is reported to share the same entry (ACE2) as SARS-CoV according to the updated findings. Analyzing the distribution and expression level of the route of coronavirus may help reveal underlying mechanisms of viral susceptibili…