Ann Chen Wu
YOU?
Author Swipe
View article: Trends in Neighborhood Opportunity, Hospitalizations, and Costs for Pediatric Asthma
Trends in Neighborhood Opportunity, Hospitalizations, and Costs for Pediatric Asthma Open
Objective To evaluate changes in (1) admissions and (2) costs of hospitalization over time relative to Child Opportunity Index (COI) levels for pediatric patients with asthma exacerbations. Study Design We conducted a retrospective study u…
View article: A chromosome-level genome assembly of the Bullacta exarata (Cephalaspidea: Haminoeidae)
A chromosome-level genome assembly of the Bullacta exarata (Cephalaspidea: Haminoeidae) Open
The mudsnail, Bullacta exarata, is an important marine food mollusk for both economic and aquaculture purposes. However, the scarcity of genomic information has hindered genetic research and breeding efforts. To address this gap, we develo…
View article: Diagnostic Evaluation and Management of Idiopathic Chylous Ascites: A Report of a Surgical Case
Diagnostic Evaluation and Management of Idiopathic Chylous Ascites: A Report of a Surgical Case Open
Chylous ascites (CA) is the pathological accumulation of lymphatic fluid in the peritoneal cavity. The ascitic fluid has a high concentration of triglycerides and chylomicrons, giving it a milky appearance. Owing to its infrequent diagnosi…
View article: Plasma pharmacometabolomics of inhaled corticosteroid–related adrenal suppression in asthma
Plasma pharmacometabolomics of inhaled corticosteroid–related adrenal suppression in asthma Open
We have identified specific metabolites within steroid and nonsteroid metabolic pathways that are associated with adrenal insufficiency with ICS use.
View article: Extracellular vesicles of Clonorchis sinensis promote the malignant phenotypes of cholangiocarcinoma via NF-κB/EMT axis
Extracellular vesicles of Clonorchis sinensis promote the malignant phenotypes of cholangiocarcinoma via NF-κB/EMT axis Open
Clonorchis sinensis infection is an important risk factor for cholangiocarcinoma (CCA). It has been reported that extracellular vesicles (EVs) are involved in the parasite-host interaction, and EVs of C . sinensis ( Cs EVs) can contribute …
View article: Urine metabolomics signature reveals novel determinants of adrenal suppression in children taking inhaled corticosteroids to control asthma symptoms
Urine metabolomics signature reveals novel determinants of adrenal suppression in children taking inhaled corticosteroids to control asthma symptoms Open
Background Asthma is routinely treated with inhaled corticosteroids (ICS). Asthma patients on ICS are at increased risk of adrenal suppression, a potentially serious effect of long‐term glucocorticoid exposure; however, this relationship i…
View article: Association of PHACTR1 with Coronary Artery Calcium Differs by Sex and Cigarette Smoking
Association of PHACTR1 with Coronary Artery Calcium Differs by Sex and Cigarette Smoking Open
Background: Coronary artery calcium (CAC) is a marker of subclinical atherosclerosis and is a complex heritable trait with both genetic and environmental risk factors, including sex and smoking. Methods: We performed genome-wide associatio…
View article: Examining the Effect of Genes on Depression as Mediated by Smoking and Modified by Sex
Examining the Effect of Genes on Depression as Mediated by Smoking and Modified by Sex Open
Depression is heritable, differs by sex, and has environmental risk factors such as cigarette smoking. However, the effect of single nucleotide polymorphisms (SNPs) on depression through cigarette smoking and the role of sex is unclear. In…
View article: GSDMB/ORMDL3 Rare/Common Variants Are Associated with Inhaled Corticosteroid Response among Children with Asthma
GSDMB/ORMDL3 Rare/Common Variants Are Associated with Inhaled Corticosteroid Response among Children with Asthma Open
Inhaled corticosteroids (ICS) are efficacious in the treatment of asthma, which affects more than 300 million people in the world. While genome-wide association studies have identified genes involved in differential treatment responses to …
View article: Machine Learning Prediction of Treatment Response to Inhaled Corticosteroids in Asthma
Machine Learning Prediction of Treatment Response to Inhaled Corticosteroids in Asthma Open
Background: Although inhaled corticosteroids (ICS) are the first-line therapy for patients with persistent asthma, many patients continue to have exacerbations. We developed machine learning models to predict the ICS response in patients w…
View article: Gaps in the Vision Screening Pathway for School-Aged US Children
Gaps in the Vision Screening Pathway for School-Aged US Children Open
This cross-sectional study uses a nationally representative survey of the US pediatric population to identify gaps in the vision screening pathway.
View article: P489: Pediatric exome sequencing compared with standard genetic testing: An analysis of private payer claims data
P489: Pediatric exome sequencing compared with standard genetic testing: An analysis of private payer claims data Open
Exome sequencing (ES) is increasingly covered by private health insurers for pediatric indications. However, few studies have used real-world data to examine the impacts of genetic and genomic testing on health care utilization over time. …
View article: P507: Newborn genomic sequencing for Duchenne muscular dystrophy: Model-based insights
P507: Newborn genomic sequencing for Duchenne muscular dystrophy: Model-based insights Open
Advances in the treatment of Duchenne muscular dystrophy (DMD), an X-linked pediatric onset neuromuscular disorder, have increased interest in early disease detection via newborn screening. Patients with DMD are typically symptomatic befor…
View article: Asthma exacerbations and eosinophilia in the UK Biobank: a genome-wide association study
Asthma exacerbations and eosinophilia in the UK Biobank: a genome-wide association study Open
Background Asthma exacerbations reflect disease severity, affect morbidity and mortality, and may lead to declining lung function. Inflammatory endotypes ( e.g. T2-high (eosinophilic)) may play a key role in asthma exacerbations. We aimed …
View article: Enrollment of Pediatric Patients in COVID-19 Interventional Trials
Enrollment of Pediatric Patients in COVID-19 Interventional Trials Open
This cross-sectional study uses information gathered from ClinicalTrials.gov to assess the inclusion of children in COVID-19 interventional trials conducted in the US.
View article: National Patterns of Outpatient Follow-Up Visits After Emergency Care for Acute Bronchiolitis
National Patterns of Outpatient Follow-Up Visits After Emergency Care for Acute Bronchiolitis Open
This cohort study examines the frequency of postdischarge follow-up visits among US emergency department encounters for bronchiolitis and assesses whether follow-up was associated with decreased hospital reutilization or increased treatmen…
View article: Vision Testing for Adolescents in the US
Vision Testing for Adolescents in the US Open
Importance Untreated refractive error contributes to the racial, ethnic, and socioeconomic disparities in visual function of adolescent children in the US. Objective To describe patterns in vision testing as a function of age among US adol…
View article: Prevalence and prescribing patterns of oral corticosteroids in the United States, Taiwan, and Denmark, 2009–2018
Prevalence and prescribing patterns of oral corticosteroids in the United States, Taiwan, and Denmark, 2009–2018 Open
Oral corticosteroids (OCS) are commonly prescribed for acute, self‐limited conditions, despite studies demonstrating toxicity. Studies evaluating longitudinal OCS prescribing in the general population are scarce and do not compare use acro…