Ann G. Zauber
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View article: Figure S4 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort
Figure S4 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort Open
Supplementary Figure S4 shows the family-history-stratified calibration on 5- and 10-year absolute risks based on the PRS-enhanced model stratified by deciles of predicted risk in GERA European ancestry participants.
View article: Table S8 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort
Table S8 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort Open
Supplementary Table S8 shows sequential model comparison using 10-year time-dependent AUC in the GERA European-ancestry participants.
View article: Table S1 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort
Table S1 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort Open
Supplementary Table S1 shows the descriptive characteristics of study populations in GECCO and CORECT.
View article: Figure S7 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort
Figure S7 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort Open
Supplementary Figure S7 shows the Sex-specific estimated baseline incidence rate of CRC based on SEER18 (2007-2015) CRC rate in European population.
View article: Supplementary Tables 1-2 and Supplementary Figures 1-4 from Impact and Recovery from COVID-19–Related Disruptions in Colorectal Cancer Screening and Care in the US: A Scenario Analysis
Supplementary Tables 1-2 and Supplementary Figures 1-4 from Impact and Recovery from COVID-19–Related Disruptions in Colorectal Cancer Screening and Care in the US: A Scenario Analysis Open
Supplementary Table 1. Published estimates of the decrease in CRC screening rates as a result of the COVID-19 pandemic (March-September) identified by our literature search. Supplementary Table 2. Published estimates of the decrease in CRC…
View article: Figure S5 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort
Figure S5 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort Open
Supplementary Figure S5 shows the age-stratified calibration on 5- and 10-year absolute risks based on the PRS-enhanced model stratified by deciles of predicted risk in GERA European ancestry participants.
View article: Figure S2 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort
Figure S2 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort Open
Supplementary Figure S2 shows the sex-stratified calibration on 5- and 10-year absolute risks based on the PRS-enhanced model stratified by deciles of predicted risk in GERA European ancestry participants.
View article: Figure S6 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort
Figure S6 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort Open
Supplementary Figure S6 shows the calibration on relative risk of PRS stratified by PRS with 7 bins in groups of different ancestry in the GERA cohort.
View article: Table S5 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort
Table S5 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort Open
Supplementary Table S5 shows sex-specific estimates of log(odds ratio) of risk factors in the proposed model.
View article: Table S7 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort
Table S7 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort Open
Supplementary Table S7 shows the 10-year time-dependent AUC estimates of the PRS-enhanced model in the GERA European- ancestry participants.
View article: Figure S1 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort
Figure S1 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort Open
Supplementary Figure S1 shows the calibration on 10-year absolute risk based on the PRS-enhanced model stratified by deciles of predicted risk in GERA European ancestry participants.
View article: Table S6 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort
Table S6 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort Open
Supplementary Table S6 shows the 10-year E/O CRC case ratio in the GERA European-ancestry participants.
View article: Table S2 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort
Table S2 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort Open
Supplementary Table S2 shows the descriptive statistics of GERA study participants by racial/ethnic groups and sex.
View article: Table S3 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort
Table S3 from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort Open
Supplementary Table S3 shows the comparison on characteristics between GECCO/CORECT study and GERA Europeans-ancestry participants
View article: Data from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort
Data from Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort Open
Background:Polygenic risk scores (PRS) which summarize individuals’ genetic risk profile may enhance targeted colorectal cancer screening. A critical step towards clinical implementation is rigorous external validations in large community-…
View article: Conventional screening measure does not accurately capture screening status in a minority of patients with colorectal cancer
Conventional screening measure does not accurately capture screening status in a minority of patients with colorectal cancer Open
Colorectal cancer (CRC) screening uptake in the Veterans Health Administration (VA) has been reported to be higher than the US general population, but CRC remains a prevalent cancer within the VA system. To examine CRC predictors and the e…
View article: Benefits of colorectal cancer screening using fecal immunochemical testing with varying positivity thresholds by age and sex
Benefits of colorectal cancer screening using fecal immunochemical testing with varying positivity thresholds by age and sex Open
Background Fecal immunochemical test (FIT) performance for colorectal cancer screening varies by age and sex, yet most FIT-based screening programs use uniform positivity thresholds. This study assessed the potential benefits of stratifyin…
View article: Implications of the initial <i>Braidwood v. Becerra</i> ruling for colorectal cancer outcomes: a modeling study
Implications of the initial <i>Braidwood v. Becerra</i> ruling for colorectal cancer outcomes: a modeling study Open
The Affordable Care Act (ACA) eliminated patient cost-sharing for United States Preventive Service Task Force (USPSTF) recommended services. However, if the US Court of Appeals for the Fifth Circuit fully upheld a US District Court ruling …
View article: Fecal Immunochemical Test Screening and Risk of Colorectal Cancer Death
Fecal Immunochemical Test Screening and Risk of Colorectal Cancer Death Open
Importance The fecal immunochemical test (FIT) is widely used for colorectal cancer (CRC) screening, but evidence of its effectiveness is limited. Objective To evaluate whether FIT screening is associated with a lower risk of dying from CR…
View article: Bias due to coarsening of time intervals in the inference for the effectiveness of colorectal cancer screening
Bias due to coarsening of time intervals in the inference for the effectiveness of colorectal cancer screening Open
Background Observational studies are frequently used to estimate the comparative effectiveness of different colorectal cancer (CRC) screening methods due to the practical limitations and time needed to conduct large clinical trials. Howeve…
View article: Characteristics of a cost-effective blood test for colorectal cancer screening
Characteristics of a cost-effective blood test for colorectal cancer screening Open
Background Blood-based biomarker tests can potentially change the landscape of colorectal cancer (CRC) screening. We characterize the conditions under which blood test screening would be as effective and cost-effective as annual fecal immu…
View article: Clinicopathological Characteristics and Risk Factors of Young-Onset Gastric Carcinoma: A Systematic Review and Meta-analysis
Clinicopathological Characteristics and Risk Factors of Young-Onset Gastric Carcinoma: A Systematic Review and Meta-analysis Open
INTRODUCTION: The characteristics of gastric carcinoma in young individuals differ from that in older individuals. We conducted a systematic review and meta-analysis to explore the clinicopathological features and risk factors associated w…
View article: Global burden of young-onset gastric cancer: a systematic trend analysis of the global burden of disease study 2019
Global burden of young-onset gastric cancer: a systematic trend analysis of the global burden of disease study 2019 Open
View article: Effectiveness and Cost-Effectiveness of Colorectal Cancer Screening With a Blood Test That Meets the Centers for Medicare & Medicaid Services Coverage Decision
Effectiveness and Cost-Effectiveness of Colorectal Cancer Screening With a Blood Test That Meets the Centers for Medicare & Medicaid Services Coverage Decision Open
View article: Prevalence of Gastric Precursor Lesions in Countries With Differential Gastric Cancer Burden: A Systematic Review and Meta-analysis
Prevalence of Gastric Precursor Lesions in Countries With Differential Gastric Cancer Burden: A Systematic Review and Meta-analysis Open
View article: Estimated US Cancer Deaths Prevented With Increased Use of Lung, Colorectal, Breast, and Cervical Cancer Screening
Estimated US Cancer Deaths Prevented With Increased Use of Lung, Colorectal, Breast, and Cervical Cancer Screening Open
Importance Increased use of recommended screening could help achieve the Cancer Moonshot goal of reducing US cancer deaths. Objective To estimate the number of cancer deaths that could be prevented with a 10–percentage point increase in th…
View article: Personalized Multilevel Intervention for Improving Appropriate Use of Colorectal Cancer Screening in Older Adults
Personalized Multilevel Intervention for Improving Appropriate Use of Colorectal Cancer Screening in Older Adults Open
Importance Despite guideline recommendations, clinicians do not systematically use prior screening or health history to guide colorectal cancer (CRC) screening decisions in older adults. Objective To evaluate the effect of a personalized m…
View article: Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations Open
View article: NordICC Trial Results in Line With Expected Colorectal Cancer Mortality Reduction After Colonoscopy: A Modeling Study
NordICC Trial Results in Line With Expected Colorectal Cancer Mortality Reduction After Colonoscopy: A Modeling Study Open
Colonoscopy screening is a widely recommended method for detecting colorectal cancer (CRC) in countries across the world.1Schreuders E.H. et al.Gut. 2015; 64: 1637-1649Crossref PubMed Scopus (843) Google Scholar However, until recently, no…
View article: Young-onset colorectal cancer
Young-onset colorectal cancer Open