Ann Saada
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View article: Bioenergetic Signatures of DLD Deficiency: Dissecting PDHc- and α-KGDHc-Linked Defects
Bioenergetic Signatures of DLD Deficiency: Dissecting PDHc- and α-KGDHc-Linked Defects Open
Dihydrolipoamide dehydrogenase (DLD) deficiency (MIM #246900) is a rare autosomal recessive mitochondrial disorder caused by pathogenic variants in the DLD gene, which encodes the E3 subunit common to multiple mitochondrial enzyme complexe…
View article: Transcriptome analysis of atad3-null zebrafish embryos elucidates possible disease mechanisms
Transcriptome analysis of atad3-null zebrafish embryos elucidates possible disease mechanisms Open
Background ATAD3A , a nuclear gene encoding the ATAD3A protein, has diverse roles in mitochondrial processes, encompassing mitochondrial dynamics, mitochondrial DNA maintenance, metabolic pathways and inter-organellar interactions. Pathoge…
View article: Myelin: A possible proton capacitor for energy storage during sleep and energy supply during wakefulness
Myelin: A possible proton capacitor for energy storage during sleep and energy supply during wakefulness Open
There are several physiological reasons why biological organisms sleep. One key one concerns brain metabolism. In our article we discuss the role of metabolism in myelin, based on the recent discovery that myelin contains mitochondrial com…
View article: Protein kinase C epsilon activation improves early survival in an acute porcine model of controlled hemorrhage
Protein kinase C epsilon activation improves early survival in an acute porcine model of controlled hemorrhage Open
Hemorrhage is the primary cause of preventable death in both military and civilian trauma cases, and the effective therapeutic options are limited. Activation of Protein Kinase C epsilon (PKC-ε) was shown to have a protective role in ische…
View article: Transcriptome analysis of<i>atad3-</i>null zebrafish embryos elucidates possible disease mechanisms
Transcriptome analysis of<i>atad3-</i>null zebrafish embryos elucidates possible disease mechanisms Open
ATAD3A , a nuclear gene encoding the ATAD3A protein, has diverse roles in mitochondrial processes, encompassing mitochondrial dynamics, mitochondrial DNA maintenance, metabolic pathways and inter-organellar interactions. Pathogenic variant…
View article: Supplementary Figure S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S2 demonstrates the infiltration of mature innate immune cells to the liver during breast carcinogenesis
View article: Supplementary Table S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S4 lists the antibodies used for FACS
View article: Supplementary Table S5 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S5 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S5 lists the antibodies used for CyTOF
View article: Supplementary Figure S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S3 shows that targeting the IL-6-pSTAT-HNF4a pathway preserves liver metabolism and restricts BC growth
View article: Supplementary Figure S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S2 demonstrates the infiltration of mature innate immune cells to the liver during breast carcinogenesis
View article: Supplementary Extended Data 1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Extended Data 1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Extended Data 1 describes the FACS gating startegy
View article: Supplementary Figure S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S1 demonstrates global metabolic changes in liver metabolism during early BC carcinogenesis
View article: Supplementary Table S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S4 lists the antibodies used for FACS
View article: Supplementary Table S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S3 lists the primers used for qPCR
View article: Supplementary Table S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S2 lists the antibodies used for western blots
View article: Supplementary Table S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S3 lists the primers used for qPCR
View article: Supplementary Figure S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S3 shows that targeting the IL-6-pSTAT-HNF4a pathway preserves liver metabolism and restricts BC growth
View article: Supplementary Table S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S1 details clinical data of PDAC patients
View article: Supplementary Table S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S1 details clinical data of PDAC patients
View article: Supplementary Extended Data 1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Extended Data 1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Extended Data 1 describes the FACS gating startegy
View article: Supplementary Figure S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S4 demonstrates similar transcriptional and metabolic changes following liver infiltration of immune cells to the liver of PDAC mice
View article: Supplementary Figure S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S4 demonstrates similar transcriptional and metabolic changes following liver infiltration of immune cells to the liver of PDAC mice
View article: Supplementary Table S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S2 lists the antibodies used for western blots
View article: Supplementary Figure S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S1 demonstrates global metabolic changes in liver metabolism during early BC carcinogenesis
View article: Supplementary Table S5 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S5 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S5 lists the antibodies used for CyTOF
View article: Supplementary Figure S5 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S5 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S5 demonstrate the significance of our liver score in predicting outcomes of BC and PDAC patients