Ann-Kristin Alteköester
YOU?
Author Swipe
View article: Germline analysis of an international cohort of pediatric diffuse midline glioma patients
Germline analysis of an international cohort of pediatric diffuse midline glioma patients Open
Background Factors that drive the development of diffuse midline gliomas (DMG) are unknown. Our study aimed to determine the prevalence of pathogenic/likely pathogenic (P/LP) germline variants in pediatric patients with DMG. Methods We ass…
View article: Integrated germline and somatic molecular profiling to detect cancer predisposition has a high clinical impact in poor-prognosis paediatric cancer
Integrated germline and somatic molecular profiling to detect cancer predisposition has a high clinical impact in poor-prognosis paediatric cancer Open
Germline predisposition has a significant role in paediatric cancer. However, the optimal approach to identifying cancer-causing germline pathogenic variants (GPV) in children, and even the prevalence of GPV among children with cancer, rem…
View article: Precision-guided treatment in high-risk pediatric cancers
Precision-guided treatment in high-risk pediatric cancers Open
Recent research showed that precision medicine can identify new treatment strategies for patients with childhood cancers. However, it is unclear which patients will benefit most from precision-guided treatment (PGT). Here we report consecu…
View article: Precision-guided treatment improves outcomes for children with high-risk cancers
Precision-guided treatment improves outcomes for children with high-risk cancers Open
Recent reports have shown that precision medicine can identify new treatment strategies for childhood cancer patients. However, it remains unclear which patients will benefit most from precision-guided treatment (PGT). Here we report 384 c…
View article: Protocol for a comprehensive prospective cohort study of trio-based whole-genome sequencing for underlying cancer predisposition in paediatric and adolescent patients newly diagnosed with cancer: the PREDICT study
Protocol for a comprehensive prospective cohort study of trio-based whole-genome sequencing for underlying cancer predisposition in paediatric and adolescent patients newly diagnosed with cancer: the PREDICT study Open
Introduction Identifying an underlying germline cancer predisposition (CP) in a child with cancer has potentially significant implications for both the child and biological relatives. Cohort studies indicate that 10%–15% of paediatric canc…
View article: Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, K <sub>Ca</sub> 1.1, in Sinus Node Function and Arrhythmia Risk
Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, K <sub>Ca</sub> 1.1, in Sinus Node Function and Arrhythmia Risk Open
Background: KCNMA1 encodes the α-subunit of the large-conductance Ca 2+ -activated K + channel, K Ca 1.1, and lies within a linkage interval for atrial fibrillation (AF). Insights into the cardiac functions of K Ca 1.1 are limited, and KCN…
View article: Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, K<sub>Ca</sub>1.1, in Sinus Node Function and Arrhythmia Risk
Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, K<sub>Ca</sub>1.1, in Sinus Node Function and Arrhythmia Risk Open
Background KCNMA1 encodes the α-subunit of the large-conductance Ca 2+ -activated K + channel, K Ca 1.1, and lies within a linkage interval for atrial fibrillation (AF). Insights into the cardiac functions of K Ca 1.1 are limited and KCNMA…