Ann M. Gregus
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View article: Medial prefrontal cortical neurotransmitters reactive to relapse-promoting and relapse-suppressing cues in rats trained to self-administer cocaine or alcohol
Medial prefrontal cortical neurotransmitters reactive to relapse-promoting and relapse-suppressing cues in rats trained to self-administer cocaine or alcohol Open
Environmental cues conditioned to signal drug availability (S+) or omission (S-) activate specific neurons (neuronal ensembles/engram cells) within the medial prefrontal cortex (mPFC) to promote and suppress drug relapse in rats. However, …
View article: The Predictive Value of Plasma Bioactive Lipids on Craving in Human Volunteers With Alcohol Use Disorder
The Predictive Value of Plasma Bioactive Lipids on Craving in Human Volunteers With Alcohol Use Disorder Open
Our findings highlight the promise of these lipid metabolites as biomarkers of heightened alcohol craving. The results open a novel opportunity for further research and clinical evaluation of these biomarkers to optimize existing treatment…
View article: Examining Cognitive Performance in Mice using the Open-Source Operant Feeding Device FED3
Examining Cognitive Performance in Mice using the Open-Source Operant Feeding Device FED3 Open
Cognitive impairments are prevalent in various neurological disorders, including chronic pain conditions, and pose significant therapeutic challenges. Preclinical rodent models serve as valuable tools for investigating the underlying mecha…
View article: Effect of chronic vapor nicotine exposure on affective and cognitive behavior in male mice
Effect of chronic vapor nicotine exposure on affective and cognitive behavior in male mice Open
Nicotine use is a leading cause of preventable deaths worldwide, and most of those who attempt to quit will relapse. While electronic cigarettes and other electronic nicotine delivery systems (ENDS) were presented as a safer alternative to…
View article: Effect of chronic vapor nicotine exposure on affective and cognitive behavior in male mice
Effect of chronic vapor nicotine exposure on affective and cognitive behavior in male mice Open
Nicotine use is a leading cause of preventable deaths worldwide, and most of those who attempt to quit will relapse. While electronic cigarettes and other electronic nicotine delivery systems (ENDS) were presented as a safer alternative to…
View article: NAPE-PLD regulates specific baseline affective behaviors but is dispensable for inflammatory hyperalgesia
NAPE-PLD regulates specific baseline affective behaviors but is dispensable for inflammatory hyperalgesia Open
N-acyl-ethanolamine (NAEs) serve as key endogenous lipid mediators as revealed by manipulation of fatty acid amide hydrolase (FAAH), the primary enzyme responsible for metabolizing NAEs. Preclinical studies focused on FAAH or NAE re…
View article: Phenelzine-based probes reveal Secernin-3 is involved in thermal nociception
Phenelzine-based probes reveal Secernin-3 is involved in thermal nociception Open
View article: Phenelzine-based probes reveal Secernin-3 is involved in thermal nociception
Phenelzine-based probes reveal Secernin-3 is involved in thermal nociception Open
Chemical platforms that facilitate both the identification and elucidation of new areas for therapeutic development are necessary but lacking. Activity-based protein profiling (ABPP) leverages active site-directed chemical probes as target…
View article: AIBP regulates TRPV1 activation in chemotherapy-induced peripheral neuropathy by controlling lipid raft dynamics and proximity to TLR4 in dorsal root ganglion neurons
AIBP regulates TRPV1 activation in chemotherapy-induced peripheral neuropathy by controlling lipid raft dynamics and proximity to TLR4 in dorsal root ganglion neurons Open
Nociceptive afferent signaling evoked by inflammation and nerve injury is mediated by the opening of ligand-gated and voltage-gated receptors or channels localized to cholesterol-rich lipid raft membrane domains. Dorsal root ganglion (DRG)…
View article: Linking drug and food addiction via compulsive appetite
Linking drug and food addiction via compulsive appetite Open
Background and Purpose ‘Food addiction’ is the subject of intense public and research interest. However, this nosology based on neurobehavioural similarities among obese individuals, patients with eating disorders and those with substance …
View article: Sex differences in neuroimmune and glial mechanisms of pain
Sex differences in neuroimmune and glial mechanisms of pain Open
Pain is the primary motivation for seeking medical care. Although pain may subside as inflammation resolves or an injury heals, it is increasingly evident that persistency of the pain state can occur with significant regularity. Chronic pa…
View article: Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes
Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes Open
Known chemoproteomic probes generally use warheads that tag a single type of amino acid or modified form thereof to identify cases in which its hyper-reactivity underpins function. Much important biochemistry derives from electron-poor enz…
View article: Druggable Targets in Endocannabinoid Signaling
Druggable Targets in Endocannabinoid Signaling Open
View article: Modeling drug exposure in rodents using e-cigarettes and other electronic nicotine delivery systems
Modeling drug exposure in rodents using e-cigarettes and other electronic nicotine delivery systems Open
View article: Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug–unresponsive hyperalgesia in male rats
Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug–unresponsive hyperalgesia in male rats Open
Although nonsteroidal anti-inflammatory drugs are the first line of therapeutics for the treatment of mild to moderate somatic pain, they are not generally considered to be effective for neuropathic pain. In the current study, direct activ…